Spectrometric systems and methods for improved focus localization of time- and space-varying measurements
First Claim
1. A method for determining a characteristic of a biological sample with a spectrometric system, the spectrometric system including at least one transmitter and at least one receiver, the method comprising:
- with a data-processing unit of the system, acquiring an output from the at least one receiver caused by the at least one transmitter'"'"'s emission of at least one electromagnetic wave (EMW) at at least one corresponding wavelength, the at least one transmitter and the at least one receiver being operably juxtaposed with the sample, the output representing an optical property of the sample determined along a path from the at least one transmitter to the at least one receiver through the sample, said path defined by a gradient of concentration of a material component in the sample;
receiving, with the data-processing unit of the system, reference data representing an empirically-defined spectrally-dependent characteristic of the sample;
determining an impulse response of the sample, the impulse response being associated with emission of the at least one EMW by the at least one transmitter; and
determining, as a function of time, at least one wavelength-dependent material parameter characterizing the sample based on a determined impulse response and the reference data.
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Abstract
A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. Dynamic localization is effectuated by considering different portions of a curve representing the determined parameter, and provides for the formation of a spatial map of distribution of the parameter across the sample. Additional measurement of impulse response at multiple detectors facilitates determination of change of the measured parameter across the sample as a function of time.
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Citations
13 Claims
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1. A method for determining a characteristic of a biological sample with a spectrometric system, the spectrometric system including at least one transmitter and at least one receiver, the method comprising:
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with a data-processing unit of the system, acquiring an output from the at least one receiver caused by the at least one transmitter'"'"'s emission of at least one electromagnetic wave (EMW) at at least one corresponding wavelength, the at least one transmitter and the at least one receiver being operably juxtaposed with the sample, the output representing an optical property of the sample determined along a path from the at least one transmitter to the at least one receiver through the sample, said path defined by a gradient of concentration of a material component in the sample; receiving, with the data-processing unit of the system, reference data representing an empirically-defined spectrally-dependent characteristic of the sample; determining an impulse response of the sample, the impulse response being associated with emission of the at least one EMW by the at least one transmitter; and determining, as a function of time, at least one wavelength-dependent material parameter characterizing the sample based on a determined impulse response and the reference data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification