Substance detection device

• US 9,739,774 B2
• Filed: 09/03/2015
• Issued: 08/22/2017
• Est. Priority Date: 09/03/2015
• Status: Active Grant

• Current Assignee: NXP B.V. (NXP Semiconductors NV)
• Original Assignee: NXP B.V. (NXP Semiconductors NV)
• Inventors: Nackaerts, Axel, Nguyen, Viet Hoang
• Primary Examiner(s): Sines, Brian J
• Application Number:
  US14/845,166
• Publication Number:
  US 20170067891A1
• Time in Patent Office: 719 Days
• Field of Search: 422 50, 422 681, 422 8201, 436 43, 436 65
• CPC Class Codes: G01N 27/227 Sensors changing capacitance upon adsorption or absorption of fluid components, e.g. electrolyte-insulator-semiconductor sensors, MOS capacitors G01N27/225 takes precedence
• CPC Class Codes: G01N 33/5438 Electrodes
• CPC Class Codes: G01N 33/54388 based on lateral flow
• CPC Class Codes: G01N 33/558 using diffusion or migration of antigen or antibody immunochromatographic test strips G01N33/54387
• CPC Class Codes: G01N 33/689 related to pregnancy or the gonads

Abstract

One example discloses a substance detection device, including: a substrate configured to carry a substance; wherein the substrate has a length and a substance loss along the length of the substrate; a test region coupled to the substrate and configured to bond to at least a portion of the substance; a sensor coupled to the substrate at a fixed location along the length and having a sensing signal output; an integration circuit coupled to the sensor and configured to integrate, over a time interval, a signal from the sensing signal output; and a detection circuit coupled to the integration circuit and configured to output a substance detected signal if the integrated sensing signal output signal deviates from the substance loss corresponding to the fixed sensor location.

Claims

1. A substance detection device, comprising:

a substrate configured to carry a substance;

wherein the substrate has a length and a substance loss along the length of the substrate;

a test region coupled to the substrate and configured to bond to at least a portion of the substance;

a sensor coupled to the substrate at a fixed location along the length and having a sensing signal output;

an integration circuit coupled to the sensor and configured to integrate, over a time interval, a signal from the sensing signal output; and

a detection circuit coupled to the integration circuit and configured to output a substance detected signal if the integrated sensing signal output signal deviates from the substance loss corresponding to the fixed sensor location.

2. The device of claim 1:

wherein the detection circuit is configured to output the substance detected signal if the integrated sensing signal output signal is either greater than or less than the substance loss corresponding to the fixed sensor location.

3. The device of claim 1:

wherein the substance loss is either a uniform per unit length or variable substance loss.

4. The device of claim 1:

wherein at the fixed location along the length, the test region is not located directly over the sensor.

5. The device of claim 1:

wherein the sensor is a capacitive sensor.

6. The device of claim 1:

wherein the substance is at least one of;

a target molecule;

a control molecule;

a conjugate molecule, a particle, DNA, a protein, an enzyme, a peptide, a small molecules or a hormone.

7. The device of claim 1:

wherein the substance is carried by at least one of;

an analyte or biological fluid.

8. The device of claim 1:

wherein the test region includes at least one of;

an antibody, a sensitive region, or a biomarker.

9. The device of claim 1:

wherein the substance detected signal is a pregnancy detected signal.

10. The device of claim 1:

wherein the sensor is included in a set of sensors 106, each having a sensing signal output, and aligned in a row along the length of the substrate at a corresponding set of fixed sensor locations;

wherein the integration circuit is coupled to the set of sensors and is configured to integrate, over the time interval, signals from the sensing signal outputs; and

wherein the detection circuit is configured to output the substance detected signal if at least one of the integrated sensing signal output signals deviates from a corresponding substance loss at that fixed sensor location.

11. The device of claim 1:

wherein the substrate is a membrane having a porosity between 66% and 98% by volume.

12. The device of claim 1:

wherein the sensor includes a set of electrodes separated from the substrate by an electrical insulator.

13. The device of claim 1:

wherein the sensor is included in a set of sensors, each having a sensing signal output, and aligned in a row along the length of the substrate at a corresponding set of fixed sensor locations; and

further comprising a substance loss circuit configured to compare the set of sensing signal outputs to calculate the substance loss.

14. The device of claim 1:

wherein the sensor is included in a set of sensors, each having a sensing signal output, and aligned in a row along the length of the substrate at a corresponding set of fixed sensor locations; and

further comprising a flow rate circuit configured to determine a volume flow rate along the substrate by comparing the set of sensing signal outputs.

15. The device of claim 1:

wherein the substrate configured to carry a second substance;

wherein the substrate has a second substance loss with respect to the second substance;

further comprising,

a control region coupled to the substrate and configured to bond to at least a portion of the second substance; and

a second sensor coupled to the substrate at a second fixed location along the length and having a second sensing signal output;

wherein the integration circuit is coupled to the second sensor and is configured to integrate, over a time interval, a signal from the second sensing signal output; and

wherein the detection circuit is configured to output a second substance detected signal if the second integrated sensing signal output signal deviates from a second substance loss corresponding to the second fixed sensor location.

16. A pregnancy test device comprising:

a substrate configured to carry a substance;

wherein the substrate has a length and a substance loss along the length of the substrate;

a test region coupled to the substrate and configured to bond to at least a portion of the substance;

a sensor coupled to the substrate at a fixed location along the length and having a sensing signal output;

an integration circuit coupled to the sensor and configured to integrate, over a time interval, a signal from the sensing signal output; and

a detection circuit coupled to the integration circuit and configured to output a pregnancy detected signal if the integrated sensing signal output signal deviates from the substance loss corresponding to the fixed sensor location.