Cardiovascular disease risk assessment

• US 9,739,790 B2
• Filed: 11/17/2015
• Issued: 08/22/2017
• Est. Priority Date: 11/17/2014
• Status: Expired due to Fees

• Current Assignee: Boston Heart Diagnostics Corporation (Eurofins Scientific SE)
• Original Assignee: Boston Heart Diagnostics Corporation (Eurofins Scientific SE)
• Inventors: Schaefer, Ernst J.
• Primary Examiner(s): GITOMER, RALPH J
• Application Number:
  US14/943,775
• Publication Number:
  US 20160139160A1
• Time in Patent Office: 644 Days
• Field of Search: None
• CPC Class Codes: G01N 2333/775 Apolipopeptides
• CPC Class Codes: G01N 2405/00 Assays, e.g. immunoassays or enzyme assays, involving lipids
• CPC Class Codes: G01N 2800/32 Cardiovascular disorders
• CPC Class Codes: G01N 2800/50 Determining the risk of developing a disease
• CPC Class Codes: G01N 33/92 involving lipids, e.g. cholesterol , lipoproteins, or their receptors steroid hormones G01N33/743
• CPC Class Codes: G16B 40/00 ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• CPC Class Codes: G16B 40/20 Supervised data analysis

Abstract

The invention provides methods for analyzing cardiovascular disease risk. Methods of the invention provide a probability of an individual developing cardiovascular disease based on parameters including blood levels of sdLDL-C, ApoA-I in α-1 HDL, and Lp(a) along with information about the patient'"'"'s age and history of blood pressure treatment, smoking, and diabetes. Methods of the invention do not rely on standard risk factor measurements, such as CRP, total cholesterol, body mass index, weight, triglycerides, and the like.

Claims

1. A method for assessing cardiovascular risk, the method comprising the steps of:

obtaining a sample from a patient;

conducting an assay on the sample to determine blood levels of sdLDL-C, ApoA1 in α

-1 HDL, and Lp(a);

obtaining information about the patient'"'"'s age and history of blood pressure treatment, smoking, and diabetes; and

determining a probability of the individual developing cardiovascular disease based on the determined blood levels and the obtained information.

2. The method of claim 1, wherein the assay comprises one selected from the group consisting of an enzymatic assay, high-performance liquid chromatography, affinity chromatography, an immunoassay, a radioassay, an enzyme-linked immunosorbent assay, colorimetry, and an electrochemical assay.

3. The method of claim 1, further comprising administering a therapy to the patient based on the determined probability of the individual developing cardiovascular disease.

4. The method of claim 3, wherein administering the therapy comprises administering a statin drug.

5. The method of claim 1, further comprising producing a report describing the cardiovascular risk for the patient.