Fast, high-rate, position-sensitive absolute dosimeter for ion beam therapy

• US 9,739,892 B2
• Filed: 04/09/2014
• Issued: 08/22/2017
• Est. Priority Date: 04/09/2014
• Status: Active Grant

• Current Assignee: Transeo Radiotherapy Solutions LLC
• Original Assignee: Phenix Medical, LLC
• Inventors: Cameron, John M., Klyachko, Alexander V., Solberg, Keith A., Vigdor, Steven E.
• Primary Examiner(s): Porta, David
• Assistant Examiner(s): BOOSALIS, FANI POLYZOS
• Application Number:
  US14/248,499
• Publication Number:
  US 20150293235A1
• Time in Patent Office: 1,231 Days
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: A61N 5/1071 for verifying the dose delivered by the treatment plan
• CPC Class Codes: G01T 1/023 Scintillation dose-rate meters

Abstract

A gas scintillation detector is designed to provide in-beam absolute dose monitoring for ion beam radiotherapy treatments employing spot or raster beam scanning, especially with microsecond-scale beam pulses. Detection of prompt primary scintillation light emitted by gas molecules excited by beam passage provides electronic signals that can be processed to yield output data proportional to delivered dose up to high dose rates, and that appear quickly enough to provide feedback to influence real-time beam intensity adjustments for subsequent steps in the beam scan. When the scintillation light is collected in multiple photo-detectors, the invention is furthermore capable of measuring spot beam position with spatial resolutions of order one millimeter.

Claims

1. A radiation detector for absolute monitoring of radiation doses delivered by an ion beam comprising:

a gas-tight housing with windows in the beam path;

a gaseous medium within the housing, wherein scintillation light is emitted by the gaseous medium after it is traversed by the ion beam;

one or more photo-detectors located within or around the gas-tight housing, the one or more photo-detectors configured to convert collected scintillation light into electric current;

further comprising a processor configured to generate a digitized electronic signal whose magnitude is proportional to the total amount of light collected by the one or more photo-detectors;

wherein the ion beam generates output data from the processor, the output data being indicative of a dose delivered by the ion beam to which the radiation detector was exposed, the output data being accurate to within 2% of the actual dose.

2. The radiation detector of claim 1, wherein the dose measurement accuracy of 2% is maintained over a full lateral extent of ion beam motion in two dimensions.

3. The radiation detector of claim 1, wherein the output data generated by the processor comprises an electronic signal whose magnitude is directly proportional to the dose delivered by the ion beam.

4. The radiation detector of claim 3, wherein the proportionality of the output data to the dose is maintained when the dose is delivered within ion beam pulses of one microsecond duration at instantaneous beam currents of up to 10 microamperes.

5. The radiation detector of claim 1, wherein the processor allows archiving of the digitized signals from each of the one or more photo-detectors on a beam-pulse-by-beam-pulse basis, or on a sampling-interval-by-sampling-interval basis, to provide a complete record of the dose delivered.

6. The radiation detector of claim 5, wherein the processor allows archiving of the digitized signals from each of the one or more photo-detectors to provide a complete record of the position at which the dose was delivered in each beam pulse or each sampling interval.

7. The radiation detector of claim 1, further comprising readout electronics coupled to the photo-detectors and to the processor and configured to integrate over time and digitize the electric current output by the one or more photo-detectors.

8. The radiation detector of claim 7, wherein the readout electronics are configured to be triggered by external electronic input signals to integrate photo-detector output electric currents only during time intervals when the ion beam is incident on the detector.

9. The radiation detector of claim 1, further comprising a photo-detector base for each of the one or more photo-detectors, wherein the photo-detector base couples its respective photo-detector to the readout electronics.

10. The radiation detector of claim 1, wherein the gas tight housing includes ion beam entry and exit windows sized to accommodate the movement of the ion beam in two dimensions.

11. The radiation detector of claim 1, wherein the one or more photo-detectors comprise one or more photomultiplier tubes, or one or more avalanche photodiodes.

12. The radiation detector of claim 1, wherein the one or more photo-detectors comprise a plurality of optical fibers or strip light guides to transport light to at least one multi-channel photo-detector.

13. The radiation detector of claim 1, wherein the at least one multi-channel photo-detector comprises at least one multi-anode photomultiplier tube.

14. The radiation detector of claim 1, further comprising wavelength-shifting optical fibers that shift the light emitted by the gaseous medium to improve overlap with a spectral response of the one or more photo-detectors.

15. The radiation detector of claim 1, wherein the gaseous medium comprises one of xenon and a mixture 95% argon with 5% carbon tetrafluoride.

16. The radiation detector of claim 1, wherein the gaseous medium is maintained at a pressure of approximately one atmosphere.

17. The radiation detector of claim 1, wherein the entire detector is mounted to a rotatable beam gantry, without interfering with a dose delivery apparatus or patient tables.

18. The radiation detector of claim 1, further comprising a quartz window to optically couple the gaseous medium and the one or more photo-detectors.

19. The radiation detector of claim 18, wherein the quartz window has an anti-reflection coating optimized for wavelengths of peak optical emission from the gaseous medium.

20. A radiation detector for absolute monitoring of radiation doses delivered by an ion beam comprising:

a gas-tight housing with windows in the beam path;

a gaseous medium within the housing, wherein scintillation light is emitted by the gaseous medium after it is traversed by the ion beam;

one or more photo-detectors located within or around the gas-tight housing, the one or more photo-detectors configured to convert collected scintillation light into electric current;

further comprising a processor configured to generate a digitized electronic signal whose magnitude is proportional to the total amount of light collected by the one or more photo-detectors;

wherein the output data of said processor are available on sub-millisecond time scales, the output data providing feedback for real-time adjustment of ion beam intensity for subsequent steps in dose delivery.

21. A radiation detector for absolute monitoring of radiation doses delivered by an ion beam comprising:

a gas-tight housing with windows in the beam path;

a gaseous medium within the housing, wherein scintillation light is emitted by the gaseous medium after it is traversed by the ion beam;

one or more photo-detectors located within or around the gas-tight housing, the one or more photo-detectors configured to convert collected scintillation light into electric current;

further comprising a processor configured to generate a digitized electronic signal whose magnitude is proportional to the total amount of light collected by the one or more photo-detectors; and

a plurality of photo-detectors located within or around the gas-tight housing, wherein the processor determines a difference between signals from oppositely-situated photo-detectors of the plurality of photo-detectors, divided by the sum of said signals, to provide output data sensitive to a distance of the ion beam from each of the oppositely-situated photo-detectors.

22. The radiation detector of claim 21, wherein the processor is configured to determine ion beam position with spatial resolution sufficient to detect beam motion from one beam pulse to the next.

23. The radiation detector of claim 22, wherein the gas-tight housing supports two or more pairs of oppositely-situated photo-detectors, wherein the processor is configured to determine two-dimensional movement of the ion beam from one beam pulse to the next.

24. The radiation detector of claim 22, wherein the processor is configured to determine ion beam position with spatial resolution of less than two millimeters in each of two dimensions.

25. The radiation detector of claim 24, wherein the spatial resolution of two millimeters is maintained over the full lateral extent of ion beam motion in two dimensions.

26. The radiation detector of claim 24, wherein the ion beam generates output data from the processor, the output data being indicative of a dose delivered by the ion beam to which the radiation detector was exposed, the output data being accurate to within 2% of the actual dose, and wherein the 2% dose accuracy and the two millimeter spatial resolution can be maintained for individual beam pulses under operating conditions in clinical applications of ion beam therapy delivery by pencil-beam scanning techniques.

27. A radiation detector for absolute monitoring of radiation doses delivered by an ion beam comprising:

a gas-tight housing with windows in the beam path;

a gaseous medium within the housing, wherein scintillation light is emitted by the gaseous medium after it is traversed by the ion beam;

one or more photo-detectors located within or around the gas-tight housing, the one or more photo-detectors configured to convert collected scintillation light into electric current;

wherein the beam entry and exit window materials and thicknesses are configured to withstand a pressure differential of more than one atmosphere, and configured to introduce less than 2 milliradians root-mean-square angular spread in a 200 MeV proton beam.

28. A radiation detector for absolute monitoring of radiation doses delivered by an ion beam comprising:

a gas-tight housing with windows in the beam path;

a gaseous medium within the housing, wherein scintillation light is emitted by the gaseous medium after it is traversed by the ion beam;

one or more photo-detectors located within or around the gas-tight housing, the one or more photo-detectors configured to convert collected scintillation light into electric current; and

one or more light-pulsers, each of which emits light at wavelengths within the spectral response region of the one or more photo-detectors, and are triggered by external electronic signals to provide periodic calibration of all photo-detector responses to reproducible amounts of light injected at known locations.

29. The radiation detector of claim 28, wherein the one or more light-pulsers comprise one or more light-emitting diodes.

30. The radiation detector of claim 28, wherein the one or more light-pulsers are embedded inside of the gas-tight housing.

31. A radiation detector for absolute monitoring of radiation doses delivered by an ion beam comprising:

a gas-tight housing with windows in the beam path;

a gaseous medium within the housing, wherein scintillation light is emitted by the gaseous medium after it is traversed by the ion beam;

one or more photo-detectors located within or around the gas-tight housing, the one or more photo-detectors configured to convert collected scintillation light into electric current;

wherein the scintillation light, emitted by the gaseous medium, has a duration of less than 100 nanoseconds.