Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability

• US 9,740,025 B2
• Filed: 08/25/2014
• Issued: 08/22/2017
• Est. Priority Date: 04/28/2011
• Status: Active Grant

• Current Assignee: Journey1, Inc.
• Original Assignee: Nexisvision, Inc.
• Inventors: De Juan, Jr., Eugene, Reich, Cary J., Alster, Yair, Clarke, Matt, Tuan, Kuangmon Ashley, Levy, Brian
• Primary Examiner(s): Alexander, William R
• Application Number:
  US14/468,075
• Publication Number:
  US 20140362338A1
• Time in Patent Office: 1,093 Days
• Field of Search: 35115901, 35115902, 35115904, 35115968
• CPC Class Codes: G02C 7/022 Ophthalmic lenses having special refractive features achieved by special materials or material structures G02C7/049 takes precedence
• CPC Class Codes: G02C 7/024 Methods of designing ophthalmic lenses
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00
• CPC Class Codes: G02C 7/047 Contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
• CPC Class Codes: G02C 7/049 Contact lenses having special fitting or structural features achieved by special materials or material structures

Abstract

An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

Claims

1. A method of correcting vision of an eye of a patient, the eye having tear liquid, a pupil, a cornea having a refractive shape, and a conjunctiva, the method comprising:

providing a lens comprising an optical component and a coupling component to an eye of a patient, wherein,

the optical component is configured to correct vision of the eye, the optical component comprising a first rigidity sufficient to resist deformation when placed on the eye so that a posterior surface extending along the optical component has a shape diverging from the refractive shape of the cornea and defines a chamber having a volume between the posterior surface and the cornea;

the coupling component is configured to contact the cornea and the conjunctiva and to support the optical component in relation to the pupil, the coupling component comprising an outer portion sized to contact the conjunctiva, an inner portion to couple to the optical component, and an intermediate portion extending between the inner portion and the outer portion;

one or more of the optical component and the coupling component comprising a plurality of fenestrations coupled to the chamber to pump the tear liquid through the plurality of fenestrations when the eye blinks, wherein the optical component is configured to move toward the cornea when the eye blinks; and

wherein the volume of the chamber decreases when the eye blinks;

wherein the eye comprises eyelids and the coupling component comprises an inner portion to couple to the optical component, an outer portion and an intermediate portion extending between the inner portion and the outer portion, wherein the inner portion corresponds to an inner portion of the cornea and the intermediate portion corresponds to an outer location of the cornea and wherein the intermediate portion comprises a resistance to deflection sufficient to form the chamber having a volume when the covering is placed on the eye with the eyelids separated and wherein the intermediate portion of the covering to deflects toward the cornea to decrease the volume of the chamber and pump the tear liquid when one or more of the eyelids contacts the intermediate portion of the coupling component; and

wherein the inner portion of the coupling component comprises a lower surface having a curvature corresponding to a curvature of an upper surface of the inner portion of the cornea and wherein the intermediate portion of the coupling component comprises a lower surface having a curvature less than an upper surface of the outer portion of the cornea such that the intermediate portion of the coupling component extends away from the outer portion of the cornea with a gap extending between the intermediate portion of the coupling component and the outer portion of the cornea and wherein the lower surface of the inner portion of the lens contacts upper surface of the inner portion of the cornea and the outer portion of the coupling component extends to the conjunctiva so as to define the chamber when the lens is placed on the eye.

2. The method of claim 1 wherein the coupling component inhibits sliding movement of the optical component relative to the pupil when the eye blinks and pumps the tear liquid.

3. The method of claim 2 wherein the lens comprises one or more inferior fenestrations located inferior to the pupil and wherein the eye rolls superiorly and the upper lid moves inferiorly such that the upper lid covers inferior fenestrations when the eye blinks.

4. The method of claim 3 wherein the eye comprises a rivulet comprising tear liquid supported with a lower lid and wherein the upper lid contacts the rivulet and draws tear liquid of the lower rivulet across the one or more lower fenestrations and upper fenestrations such that the tear liquid of the rivulet is drawn through the fenestrations.

5. The method of claim 1 wherein the volume of the chamber increases and the coupling component contacts the conjunctiva when lids of the eye open so as to inhibit flow of tear liquid between the conjunctiva and the coupling component such that the tear liquid flows into the chamber through the fenestrations.

6. The method of claim 1 wherein the volume of the chamber decreases when the lids of the eye close such that tear liquid is pumped from the chamber through the fenestrations and in between the conjunctiva and an outer portion coupling component.

7. The method of claim 1 wherein the eye comprises a limbus and wherein the outer portion of the coupling component comprises a second resistance to deflection sufficient to form the chamber with the gap extending between at least a portion of the limbus and the outer portion of the lens when the lens is placed on the eye.

8. The method of claim 1 wherein the lens is placed on the eye.

9. The method of claim 8 wherein the coupling component comprises an outer elastic portion having a lower curved surface to contact the conjunctiva and wherein a curvature of the lower curved surface corresponds to a radius of curvature less than a radius of curvature of the conjunctiva such that the lower curved surface stretches elastically when the eye blinks and a eyelid urges the optical component downward toward the cornea.

10. The method of claim 8 wherein the tear liquid is drawn through the fenestrations toward the cornea when the eyelid moves away from the lens and wherein the tear liquid flows away from the cornea when the eyelid moves toward the lens.

11. The method of claim 10 wherein an amount of medicament is drawn through the fenestrations toward the cornea when the eyelid moves away from the lens and wherein a portion of the amount of the medicament flows away from the cornea when the eyelid moves toward the lens.

12. The method of claim 1 wherein the coupling component supports the optical component in a substantially fixed relation to the pupil.

13. The method of claim 1 wherein the coupling component comprises an outer portion sized to contact the conjunctiva, an inner portion to couple to the optical component, and an intermediate portion extending between the inner portion and the outer portion.

14. The method of claim 1 wherein the coupling component comprises a deflectable material that inhibits passage of the tear liquid through the material such that the tear liquid passes through the fenestrations when the eye blinks and an eyelid exerts pressure on the optical component.

15. The method of claim 14 wherein the coupling component comprises a first configuration when the eyelid is away from the optical component and a second configuration when the eyelid exerts pressure on the optical component and wherein the deflectable material of the coupling component comprises an elastically deformable material that conforms elastically to at least a portion of the eye when the eye blinks and wherein the coupling component returns to the first configuration when the eyelid has moved away from the optical component.

16. The method of claim 15 wherein a sealing surface of the coupling component is separated from the conjunctiva with a gap when the coupling component comprises the first configuration with the eyelid away from the optical component and wherein the sealing surface of the coupling component contacts the conjunctiva when the eyelid exerts pressure on the first coupling component to form a seal with the conjunctiva.

17. The method of claim 14 wherein the optical component comprises a first rigidity and the coupling component comprises a second rigidity less than the first rigidity and wherein the optical component comprises a substantial surface area such that pressure of an eyelid on a portion of the optical component provides volumetric pumping of the tear liquid through the fenestrations when the eye blinks and deflects the coupling component.

18. The method of claim 17 wherein the deflectable material of the coupling component defines a chamber with the cornea and the conjunctiva and allows the optical component to move downward on the cornea with pressure of the eyelid so as to decrease a volume of the chamber and displace tear liquid with flow outwardly through the fenestrations when the outer portion contacts the conjunctiva.

19. The method of claim 18 wherein the deflectable material of the coupling component allows the optical component to move away from the cornea with decreased pressure of the eyelid so as to increase the volume of the chamber and draw tear liquid with inward flow through the fenestrations and into the chamber when the outer portion contacts the conjunctiva.

20. The method of claim 19 wherein the deflectable material of the coupling component contacts the conjunctiva to inhibit tear flow along the conjunctiva when the volume of the chamber increases and draws the tear liquid into the chamber through the fenestrations.

21. The method of claim 20 wherein one or more eyelids cover the fenestrations and move one or more of the optical component or the coupling component with pressure of the one or more eyelids so as to decrease a volume of the chamber and displace tear fluid from the chamber with outward flow between the conjunctiva and the coupling component.

22. The method of claim 17 wherein the outer portion comprises a third rigidity less than the first rigidity and the second rigidity such that the third portion contacts the conjunctiva and stretches elastically to move the optical component toward the cornea and pump tear liquid outwardly through the fenestrations when the eye blinks and an eye lid exerts downward pressure on the optical component and wherein the elastically stretched outer portion moves the optical component away from the cornea and pumps tear liquid inwardly through the fenestrations with flow when the eye blinks and exerts downward pressure on the optical component.

23. The method of claim 17 wherein the optical component comprises a maximum dimension across of at least about 5 mm corresponding to the substantial surface area, the substantial surface area comprising at least about 15 mm².

24. The method of claim 17 wherein the first rigidity comprises a relative rigidity within a range from about 3.5E-5 Pa-m³ to about 6E-4 Pa-m³ and the second rigidity comprises a relative rigidity within a range from about 2.5E-6 Pa-m³ to about 3E-4 Pa-m³.

25. The method of claim 1 wherein the inner portion, the intermediate portion and the outer portion are sized and curved such that the peripheral portion couples to the conjunctiva to inhibit sliding movement of the optical component along the cornea and to inhibit tear flow at locations where the inner portion couples the conjunctiva when the eye blinks.

26. The method of claim 25 wherein the outer portion comprises an elastic material and a lower surface to contact the conjunctiva, the lower surface corresponding to a radius of curvature no more than a radius of curvature of the conjunctiva such that the outer portion stretches so as to conform to the conjunctiva and form a seal with the conjunctiva when the eye blinks.

27. The method of claim 26 wherein a lower surface of the intermediate portion comprises a first slope angle and a first curvature where the intermediate portion meets the outer portion and wherein the lower surface of the outer portion comprises a second slope angle and a second curvature where the outer portion meets the intermediate portion, the first curvature greater than the second curvature, and wherein the second slope angle is aligned with the first slope angle to inhibit ridge formation along a boundary where the outer portion meets the intermediate portion.

28. The method of claim 26 wherein the lower surface comprises a first non-stretched radius of curvature of no more than about 12 mm such that the radius of curvature of the lower surface increases from the first non-stretched curvature to a second stretched curvature corresponding to the radius of curvature of the conjunctiva when the lower surface of the outer portion contacts the conjunctiva.

29. The method of claim 1 wherein the lens comprises a contact lens and wherein the optical component comprises a lower surface and an upper surface, the lower surface having first curvature corresponding to a curvature of the cornea, the upper surface comprising a surface elevation profile corresponding to an optical correction of the eye and wherein the optical component is attached to the coupling component.

30. The method of claim 29 wherein the surface elevation profile and the optical correction correspond to correction of one or more of spherical refractive error, astigmatic refractive error, spherical aberration correction, wavefront aberration correction, or presbyopia correction.

31. The method of claim 30 wherein the intermediate portion comprises a lower surface having a plurality of curvatures.

32. The method of claim 31 wherein the plurality of curvatures comprises a first curvature having a first radius of curvature and a second curvature having a second radius of curvature.

33. The method of claim 32 wherein the intermediate portion comprises an inner intermediate portion having the first radius of curvature and a second intermediate portion having the second radius of curvature, the first radius of curvature less than the second radius of curvature, wherein the first intermediate portion comprises a first slope angle proximate to the second intermediate portion and the second intermediate portion comprises a second slop angle proximate to the first intermediate portion and wherein the first slope angle is aligned with the second slope angle to inhibit ridge formation along a boundary where the first intermediate portion meets the second intermediate portion.

34. The method of claim 31 wherein the plurality of curvatures of the intermediate portion corresponds to curvatures of an aspheric surface having a conic constant and wherein the conic constant corresponds to a first radius of curvature at a first radial location away from a center of the optical component and a second radius of curvature at a second radial location away from the center of the optical component.

35. The method of claim 1 wherein the optical component comprises a first polymeric material, the first polymeric material having covalent bonds similar to the second material such that the optical component is bonded to the coupling component with covalent bonds.

36. The method of claim 1 wherein the optical component comprises silicone having first siloxane bonds, the coupling component comprises silicone having second siloxane bonds, and the third component comprises silicone having third siloxane bonds such that each of the optical component, the coupling component and the third component are bound to each other with the first covalent siloxane bonds, the second covalent siloxane bonds and the third covalent siloxane bonds.

37. The method of claim 1 wherein at least an upper surface of the lens is coated with one or more of a plasma coating, a chemical vapor deposition, or a luminous chemical vapor deposition.

38. The method of claim 1 wherein the plurality of fenestrations is located away from the optical component to pump tear liquid under the optical component.

39. The method of claim 1 wherein the plurality of fenestrations is located away from the optical component to inhibit optical effects of the plurality of fenestrations.

40. The method of claim 39 wherein each of the plurality of fenestrations comprises a diameter within a range from about 0.05 mm to about 0.5 mm.

41. The method of claim 39 wherein the optical component comprises a first center and the coupling component comprises a second center and wherein the first center is located away from the second center to align the optical component with the pupil when the coupling component is coupled to the conjunctiva and aligned with an axis of the eye.

42. The method of claim 1 wherein the lens comprises an extended wear lens capable of being safely worn continuously on the eye without removal for at least about seven days.

43. The method of claim 1, wherein the outer portion comprises a second rigidity, wherein the second rigidity is less than the first rigidity.