Apparatus for biological sensing and alerting of pharmaco-genomic mutation

• US 9,740,817 B1
• Filed: 05/26/2005
• Issued: 08/22/2017
• Est. Priority Date: 10/18/2002
• Status: Expired due to Fees

• Current Assignee: Antonia Teresita Ancheta Maninang, Dennis Sunga Fernandez
• Original Assignee: Antonia Teresita Ancheta Maninang, Dennis Sunga Fernandez
• Inventors: Fernandez, Dennis Sunga, Maninang, Antonia Teresita Ancheta
• Primary Examiner(s): Lin, Jerry
• Application Number:
  US11/140,438
• Time in Patent Office: 4,471 Days
• Field of Search: 702 19
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16B 20/20 Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• CPC Class Codes: G16B 30/00 ICT specially adapted for sequence analysis involving nucleotides or amino acids
• CPC Class Codes: G16B 5/00 ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• CPC Class Codes: G16B 5/20 Probabilistic models
• CPC Class Codes: G16B 99/00 Subject matter not provided for in other groups of this subclass
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 70/20 relating to practices or guidelines
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Electronic label processor compares bioinformatic values to determine pharmaco-genomic mutation associated with host. Label display indicates pharmaco-genomic mutation, which is network-accessible for modified medical message. Bioinformatic values are determined preferably at different times.

Claims

1. Apparatus for biological sensing and alerting of TPMT, GPCR, or CYP2D6 pharmaco-genomic mutations device integrated with semiconductor nanocrystal or quantum-dot device for multi-sensing of TPMT, GPCR, or CYP2D6 pharmacogenomic mutations in real-time of the same patient or host to alert potential or actual medical associated risk with organ transplant, paternity identification, genetically-modified agricultural crops, antisense, and gene vaccine or therapy comprising:

at least one or more integrated or implantable sensors for real-time detection of TPMT, GPCR, or CYP2D6 pharmaco-genomic mutations of in vivo or in vitro biological material of a patient or host in order to generate a bioinformatic-value signal, wherein said one or more sensor detects the TPMT, GPCR, or CYP2D6 pharmaco-genomic mutations using said semiconductor nanocrystal or said quantum-dot device to sense as detectable label or probe by linking or bonding to one or more affinity molecules of a detectable substance in an analyte in real-time for the same patient or host whereupon nanocrystal probe in response to a first energy associated with a presence of detectable substance within material bonded to the probe excites the nanocrystal in the probe and causes the probe to provide a second energy or generate or fluoresce a distinct wavelength signal indicating the presence, bioinformatic-value signal being formatted according to clinical trial FDA pharmaco-genomic submission data according to the sensing of the TPMT, GPCR, or CYP2D6 pharmaco-genomic mutations consisting essentially of genotype, haplotype, phenotype, or derived analysis format; and

pathways and system biology information for data, models, and simulations of networks and pathways, based on pair-wise labeled relationships between proteins, genes, RNA transcripts, and virtual cell systems, whereby design synthesis, test, and simulation of virtual cell system biology enable perturbation or mutagenesis stimulation to predict behavior according to host drug metabolism, transport, distribution, or excretion to alert potential or actual medical associated risk with organ transplant, paternity identification, genetically-modified agricultural crops, anti-sense, and gene vaccine or therapy;

software and hardware analysis tool coupled to said at least one integrated or implantable sensor integrated with said semiconductor nanocrystal or said quantum-dot device for multi-sensing of TPMT, GPCR, or CYP2D6 pharmaco-genomic mutations in real-time of the same patient or host, for processing the bioinformatic-value signal to determine pharmaco-genomic mutations associated with said patient or host by comparing electronically the bioinformatic-value signal to determine, via integrated or implantable multi-sensor detection in real-time of the same patient or host, pharmaco-genomic mutations comprising TPMT, GPCR, or CYP2D6, wherein the analysis tool electronically compares the bioinformatic-value signal using simple identical or substantial equivalent value check between recently-measured value and previously-stored value for same host after host exposure to radiation and other carcinogenic sources, whereby such comparison adapts iteratively and dynamically in real-time using multiple and parallel processors based on currently and recently-measured, monitored, and sensed host bioinformatic values using fuzzy system, Bayesian, or neural network to improve compute and processing performance by comparing initially values that previously are known and recorded to be related, and likely to be related or otherwise weighted, to pharmaco-genomic mutation, such that the comparison serves to detect presence or absence of the bioinformatic-value signal consisting essentially of oncogene, tumor suppressor gene, allele, enzyme, repeat sequence, micro-deletion, and other mutant gene product, protein, and metabolome that causes, or increases or decreases risk of one or more host disease, disorder, syndrome, and allergy, thereby enabling the analysis tool to alert potential or actual medical associated risk with organ transplant, paternity identification, genetically-modified agricultural crops, antisense and gene vaccine or therapy, whereby electronic access by the analysis tool to the further modified bioinformatic-value signal is restricted, secured, encrypted, and excluded unless the host explicitly and voluntarily provides prior informed consent to access such information;

an alert device coupled to the analysis tool for indicating electronically the determined pharmaco-genomic mutations, wherein said alert device generates visible or audible alert to medical professionals in prioritized or hierarchical manner, to reveal graphically or audibly through I/O in emphasized or highlighted context, higher-risk likelihood or more serious toxicity or patient risk, said alert device further indicates or warns when wrong or inappropriate medication was or is delivered to particular patient having pharmaco-genomic profile, wherein the analysis tool causes the bioinformatic-value signal to annotate clinical hypothesis definition, experiment design, sample preparation and distribution, experiment run, data acquisition, result analysis, data mining, design refinement, modeling, knowledge discovery, or project report according to pharmaco-genomics, gene expression, high-throughput sequencing, or structural or functional proteomics use-case domains, thereby enabling electronic alert of potential or actual medical associated risk with organ transplant, paternity identification, genetically-modified agricultural crops, antisense, and gene vaccine or therapy via integrated or implantable multi-sensor detection in real-time of the same patient or host using integrated semiconductor nanocrystal or quantum-dot device for integrated or implantable multi-sensing of TPMT, GPCR, or CYP2D6 pharmaco-genomic mutations in real-time of the same patient or host; and

a display wherein said display is integrated with said analysis tool and said at least one or more integrated or implantable sensors, wherein the display may visually, audibly, or graphically indicate to a physician, nurse, or other medical or technical staff textual, symbolic, or graphical representation of one or more detected pharmaco-genomic mutation or other incorporated I/O at any indicative time from analysis tool such that displayed indication may be network-accessible and said display further comprises an on-screen searching capability for use by a physician, nurse, or other medical or technical staff for potential modification of I/O medical related message representation at any time in-line with real-time said integrated or implantable sensor signal generation.

2. The apparatus of claim 1 wherein:

at least one of the integrated or implantable sensor further comprises a nucleic acid probe for nucleic acid-based diagnostic, de novo sequencing, or detecting reaction between target molecule and probe.

3. The apparatus of claim 1 wherein:

said analysis tool further comprises a TPMT, GPCR, and CYP2D6 test for alerting a medical professional when a patient is at risk for a pharmaco-genomic toxicity.

4. The apparatus of claim 1 wherein:

said alert device indicates a hierarchy or priority via said display associated with the determined pharmaco-genomic mutations associated with a medical or toxic risk after the patient or host is exposed to a radiation or carcinogenic source.