Evaluation of co-registered images of differently stained tissue slices
First Claim
1. A method comprising:
- displaying a first digital image of a first tissue slice on a graphical user interface such that an area of the first digital image is enclosed by a frame, wherein the displayed portion of the first digital image is larger than the frame;
displaying a portion of a second digital image of a second tissue slice on the graphical user interface, wherein the first tissue slice and the second tissue slice are both z slices taken from a tissue sample at corresponding positions in the x and y dimensions, wherein the displayed portion of the second digital image has a shape of the frame, wherein the area of the first digital image that is enclosed by the frame corresponds to the displayed portion of the second digital image, wherein the area of the first digital image that is enclosed by the frame is co-registered with the displayed portion of the second digital image; and
shifting the displayed portion of the second digital image in the x and y dimensions to coincide with the area of the first digital image that is enclosed by the frame as the frame is shifted in the x and y dimensions over the stationary first digital image.
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Abstract
A method for co-registering images of tissue slices stained with different biomarkers displays a first digital image of a first tissue slice on a graphical user interface such that an area of the first image is enclosed by a frame. Then a portion of a second image of a second tissue slice is displayed such that the area of the first image enclosed by the frame is co-registered with the displayed portion of the second image. The displayed portion of the second image has the shape of the frame. The tissue slices are both z slices of a tissue sample taken at corresponding positions in the x and y dimensions. The displayed portion of the second image is shifted in the x and y dimensions to coincide with the area of the first image that is enclosed by the frame as the user shifts the first image under the frame.
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Citations
17 Claims
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1. A method comprising:
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displaying a first digital image of a first tissue slice on a graphical user interface such that an area of the first digital image is enclosed by a frame, wherein the displayed portion of the first digital image is larger than the frame; displaying a portion of a second digital image of a second tissue slice on the graphical user interface, wherein the first tissue slice and the second tissue slice are both z slices taken from a tissue sample at corresponding positions in the x and y dimensions, wherein the displayed portion of the second digital image has a shape of the frame, wherein the area of the first digital image that is enclosed by the frame corresponds to the displayed portion of the second digital image, wherein the area of the first digital image that is enclosed by the frame is co-registered with the displayed portion of the second digital image; and shifting the displayed portion of the second digital image in the x and y dimensions to coincide with the area of the first digital image that is enclosed by the frame as the frame is shifted in the x and y dimensions over the stationary first digital image. - View Dependent Claims (2, 3, 4, 5)
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6. A method comprising:
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displaying a first digital image of a first tissue portion on a graphical user interface such that an area of the first digital image is enclosed by a frame, wherein the displayed portion of the first digital image is larger than the frame; displaying a second digital image of a second tissue portion on the graphical user interface; and displaying a third digital image of a third tissue portion on the graphical user interface adjacent to the second digital image, wherein the first, second and third tissue portions are z slices taken from a tissue sample at corresponding positions in the x and y dimensions, wherein each of the second digital image and the third digital image has a shape of the frame, wherein the area of the first digital image that is enclosed by the frame is co-registered with both the second digital image and the third digital image, and wherein the second digital image shifts in the x and y dimensions to coincide with the area of the first digital image that is enclosed by the frame as the first digital image is shifted in the x and y dimensions under the stationary frame. - View Dependent Claims (7, 8, 9, 10)
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11. A method comprising:
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displaying a first digital image of a first tissue slice on a graphical user interface such that an area of the first digital image is enclosed by a frame, wherein the displayed portion of the first digital image is larger than the frame; displaying a portion of a second digital image of a second tissue slice on the graphical user interface, wherein the displayed portion of the second digital image has a size of the frame, wherein the area of the first digital image that is enclosed by the frame corresponds to the displayed portion of the second digital image, wherein the area of the first digital image that is enclosed by the frame is co-registered with the displayed portion of the second digital image; and shifting the displayed portion of the second digital image to coincide with the area of the first digital image that is enclosed by the frame in response to a user shifting the frame relative to the first digital image, wherein the frame is shifted relative to the first digital image by shifting the frame over the stationary first digital image or by shifting the first digital image under the stationary frame. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification