Method for non-invasive blood glucose monitoring and method for analysing biological molecule

• US 9,743,864 B2
• Filed: 04/27/2012
• Issued: 08/29/2017
• Est. Priority Date: 04/29/2011
• Status: Active Grant

• Current Assignee: Taiwan Biophotonic Corporation
• Original Assignee: Taiwan Biophotonic Corporation
• Inventors: Li, Yu-Tang, Chu, Chang-Sheng, Fan, Chih-Hsun, Chung, Shuang-Chao, Li, Ming-Chia, Chen, Jyh-Chern, Tiao, Kuo-Tung
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US13/457,517
• Publication Number:
  US 20120277557A1
• Time in Patent Office: 1,950 Days
• Field of Search: 600310, 600318, 600319, 600320, 600321, 600316, 600322, 600340, 600344, 600473, 600476
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14558 by polarisation

Abstract

A method for non-invasive blood glucose monitoring includes the following steps. At least one ray of light is emitted from at least one light source. The light emitted from the light source is leaded into an eyeball and focused on the eyeball through a first beam splitter. The reflected light reflected from the eyeball is transmitted through the first beam splitter to a set of photo detectors. Optical angular information and absorption energy information of the reflected light transmitted to the set of photo detectors are measured. Optical angular difference and absorption energy difference resulting from the light emitted from the light source and the reflected light transmitted to the set of photo detectors are obtained. Glucose information is obtained by analyzing the optical angular difference and the absorption energy difference, and since glucose information has a corresponding relationship with blood glucose information, blood glucose information may be read.

Claims

1. A method for non-invasive glucose monitoring by measuring at least two properties of reflected light from inside an eyeball and using a process that uses the two measured properties together to do the glucose monitoring, comprising:

emitting, using at least one light source, at least one ray of light;

transmitting, using a first beam splitter having a focusing function, the light emitted from the light source into an anterior chamber of the eyeball;

focusing, using the first beam splitter, the light on the anterior chamber of the eyeball, whereby the reflected light from the anterior chamber of the eyeball is generated;

simultaneously measuring, using a set of light sensing elements, the at least two properties of the reflected light from the eyeball transmitted by the first beam splitter and a polarizer to the set of light sensing elements, the measured at least two properties comprising optical angular information of the polarized light and absorption energy information of the reflected light;

simultaneously obtaining, using a processing unit, an optical angular difference and an absorption energy difference between the light emitted from the light source and the reflected light transmitted to the set of light sensing elements by processing the at least two measured properties; and

obtaining, using the processing unit, a biological molecule information of a biological molecule by analyzing both the optical angular difference and the absorption energy difference using at least one first polynomial equation and at least one second polynomial equation, the first polynomial equation representing a relationship between the biological molecule information and the optical angular difference, and the second polynomial equation representing a relationship between the biological molecule information and the absorption energy difference;

wherein the biological molecule at least comprises a glucose, and the biological molecule information comprises the glucose information.

2. The method for non-invasive glucose monitoring as recited in claim 1, wherein the processing unit comprises an analog digital circuit integration module, wherein the analog digital circuit integration module comprises a microprocessor, an amplifier and an analog digital converter.

3. The method for non-invasive glucose monitoring as recited in claim 2, wherein the analog digital circuit integration module further comprises a wireless transmission device.

4. The method for non-invasive glucose monitoring as recited in claim 1, further comprising controlling an optical characteristic of the light source, an opto-element offset or the combination thereof, wherein the optical characteristic of the light source comprises using the light source to control an emitting frequency of the light, an intensity of the light, a length of turn-on time of the light, a length of turn-off time of the light, or a combination thereof.

5. The method for non-invasive glucose monitoring as recited in claim 1, further comprising detecting a light information of the light from the first beam splitter, before the light is directed into the eyeball, to perform a feedback control on the optical characteristic of the light.

6. The method for non-invasive glucose monitoring as recited in claim 5, wherein the light information comprises at least one of an energy information and a position information.

7. The method for non-invasive glucose monitoring as recited in claim 5, wherein the light information is detected by at least one of an optical power meter and an optic sensor.

8. The method for non-invasive glucose monitoring as recited in claim 5, wherein the feedback control on the optical characteristic is performed by the processing unit, an alarm or a light source control unit.

9. The method for non-invasive glucose monitoring as recited in claim 1, wherein the biological molecule comprises a cholesterol, an uric acid, a water, a lactic acid, an urea, an ascorbic acid, or a combination thereof.

10. The method for non-invasive glucose monitoring as recited in claim 9, wherein the biological molecule comprises an interference molecule.

11. The method for non-invasive glucose monitoring as recited in claim 10, wherein the step of obtaining the molecule information, which comprises the glucose information, comprises removing interference caused by the interference molecule.

12. The method for non-invasive glucose monitoring as recited in claim 1, wherein an optical angular measuring device comprises the polarizer and one of the light sensing elements to measure the optical angular information of the polarized light, and an energy measuring device comprises another one of the light sensing elements to measure the absorption energy information of the reflected light reflected from the eyeball, the optical angular measuring device and the energy measuring device receive the reflected light reflected from or passed through the first beam splitter.

13. The method for non-invasive glucose monitoring as recited in claim 12, wherein the optical angular measuring device and the energy measuring device are arranged at a same side of the first beam splitter, further comprising transmitting the reflected light reflected from the aqueous humor of the eyeball to a second beam splitter through the first beam splitter and then transmitting to the set of light sensing elements by the second beam splitter.

14. The method for non-invasive glucose monitoring as recited in claim 13, wherein the reflected light passing through the second beam splitter is first transmitted to the optical angular measuring device and then transmitted to the energy measuring device, and the reflected light reflected from the second beam splitter is first transmitted to another optical angular measuring device and then transmitted to another energy measuring device.

15. The method for non-invasive glucose monitoring as recited in claim 13, wherein the reflected light passes through the second beam splitter to form two rays of light, one ray is first transmitted to the optical angular measuring device and then transmitted to the energy measuring device, and the other ray is first transmitted to another optical angular measuring device and then transmitted to another energy measuring device.

16. The method for non-invasive glucose monitoring as recited in claim 12, wherein upon a condition that the optical angular measuring device and the energy measuring device are arranged at a same side of the first beam splitter, the reflected light through the first beam splitter is first transmitted to the optical angular measuring device and then transmitted to the energy measuring device.

17. The method for non-invasive glucose monitoring as recited in claim 1, wherein the measurement of the optical angular information comprises using an active measuring method or a passive measuring method.

18. The method for non-invasive glucose monitoring as recited in claim 17, wherein the active measuring method comprises using an analyzer for measuring the optical angular information.

19. The method for non-invasive glucose monitoring as recited in claim 17, wherein the passive measuring method comprises using at least one passive measuring device to measure the optical angular information, wherein the passive measuring device comprises the polarizer, and the passive measuring device measures the optical angular information by measuring an energy of the reflected light passing through the polarizer.

20. The method for non-invasive glucose monitoring as recited in claim 1, further comprising determining a measuring position of the eyeball using aligning a sight-line of the eye with an eye-alignment position device.

21. A method for non-invasive glucose monitoring by measuring at least two optical properties of reflected light from inside an eyeball and using a process that uses the two measured optical properties together to do the glucose monitoring, comprising:

emitting, using at least one light source, at least one ray of light;

transmitting, using a first beam splitter having a focusing function, the light from the light source into an anterior chamber of the eyeball;

focusing, using the first beam splitter, the light in the anterior chamber of the eyeball, whereby the reflected light is generated from the anterior chamber of the eyeball;

simultaneously measuring, using a set of light sensing elements, the at least two optical properties of the reflected light reflected from the eyeball to the set of light sensing elements;

wherein measuring the at least two optical properties of the reflected light from the eyeball comprises measuring both optical angular information of a polarized light through a polarizer and absorption energy information of the reflected light; and

simultaneously determining, using a processing unit, the glucose information of the eyeball using both the optical angular information and the absorption energy information of the reflected light from the eyeball using at least one first polynomial equation and at least one second polynomial equation, the first polynomial equation representing a relationship between the glucose information and the optical angular information, and the second polynomial equation representing a relationship between the glucose information and the absorption energy information.