Combination treatments

• US 9,744,074 B2
• Filed: 09/08/2015
• Issued: 08/29/2017
• Est. Priority Date: 12/16/2010
• Status: Active Grant

• Current Assignee: Scion Neurostim Incorporated
• Original Assignee: Scion Neurostim, LLC
• Inventors: Rogers, Lesco L.
• Primary Examiner(s): Peffley, Michael
• Assistant Examiner(s): ZINK, AMANDA L
• Application Number:
  US14/847,580
• Publication Number:
  US 20150374538A1
• Time in Patent Office: 721 Days
• CPC Class Codes: A61F 2007/0005 Ears
• CPC Class Codes: A61F 2007/0075 using a Peltier element, e.g. near the spot to be heated or cooled
• CPC Class Codes: A61F 2007/0093 programmed
• CPC Class Codes: A61F 2007/0096 with a thermometer
• CPC Class Codes: A61F 2007/0261 medicated
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients

Abstract

A method of treating a subject in need thereof, is carried out by (a) administering said subject a therapeutic intervention (e.g., an active agent) in a treatment effective amount; and concurrently (b) administering said subject caloric vestibular stimulation in a treatment effective amount, said caloric vestibular stimulation administered so as to enhance the efficacy of said active agent. In some embodiments, the caloric vestibular stimulation is administered as an actively controlled time varying waveform.

Claims

1. A method of treating a subject afflicted with headache and in need of treatment thereof, comprising:

(a) administering said subject an active agent in a treatment effective amount; and

concurrently

(b) administering said subject caloric vestibular stimulation in a treatment effective amount, said caloric vestibular stimulation administered so as to enhance the efficacy of said active agent, wherein said caloric vestibular stimulation is administered as an actively controlled time varying waveform and the subject is afflicted with headache, and said active agent comprises a headache medication or an analgesic for treating headache.

2. The method of claim 1, wherein said active agent is administered orally.

3. The method of claim 1, wherein said headache is chronic migraine headache.

4. The method of claim 1, wherein said headache is episodic migraine headache.

5. The method of claim 1, wherein said caloric vestibular stimulation is administered for a time sufficient to induce nystagmus over a period of at least five minutes.

6. The method of claim 1, wherein said headache is a tension-type headache.

7. The method of claim 1, wherein said headache is a trigeminal autonomic cephalagias headache.

8. The method of claim 1, wherein said headache is a vestibular migraine headache.