Modular ingestible drug delivery capsule

• US 9,744,139 B2
• Filed: 04/02/2010
• Issued: 08/29/2017
• Est. Priority Date: 04/07/2009
• Status: Active Grant

• Current Assignee: Biora Therapeutics Incorporated
• Original Assignee: STOCO 10 GmbH (Loratech AG)
• Inventors: Dijksman, Johan Frederik, Pierik, Anke, De Jongh, Frits Tobi, Shimizu, Jeff, Zou, Hans, Albu, Lucian Remus, Weiner, Olaf
• Primary Examiner(s): Hayman, Imani
• Assistant Examiner(s): SCHELL, LAURA C
• Application Number:
  US13/262,841
• Publication Number:
  US 20120116358A1
• Time in Patent Office: 2,706 Days
• Field of Search: 6048911, 6048921
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61K 9/4808 characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release capsules filled with granules or microparticles A61K9/16; filled with microcapsules or coated microparticles A61K9/50; with mixture of different granules, microcapsules, (coated) microparticles A61K9/5084
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

Claims

1. An ingestible capsule for delivery of a drug, the capsule comprising:

a first module comprising;

a sidewall defining a drug compartment for containing an amount of the drug,

a window formed as an opening through the sidewall of the drug compartment;

a foil fixed to the sidewall of the drug compartment and covering the window,

a conducting heating wire contacting the foil,

an indicator conducting trace across the conducting heating wire, and

at least one first conductive element electrically connected to the conducting heating wire, and

a second module comprising;

a power source;

electronics in communication with the power source for controlling an electrical pulse, and

at least one second conductive element electrically connected to the power source,

wherein securing the first module to the second module electrically connects the first conductive element and the second conductive element to electrically couple the heating wire to the electronics, and

wherein the conducting heating wire is configured to break the foil with an applied current and breaking the foil causes the indicator conducting trace to open at the portion extending across the conducting heating wire, the opening of the indicator conducting trace indicating that the conducting heating wire has broken the foil.

2. An ingestible capsule as claimed in claim 1, further comprising a sliding contact for securing the first module to the second module.

3. An ingestible capsule as claimed in claim 1, further comprising a set of pins and sockets for securing the first module to the second module.

4. An ingestible capsule as claimed in claim 1, further comprising a screw thread for securing the first module to the second module.

5. An ingestible capsule as claimed in claim 1, wherein the electronics comprise at least one capacitor for increasing an intensity of the electrical pulse.

6. An ingestible capsule as claimed in claim 1, wherein an inner wall of the drug compartment is provided with an anti-sticking layer.

7. An ingestible capsule as claimed in claim 1, wherein the foil comprises a plastic.

8. An ingestible capsule as claimed in claim 7, wherein the plastic comprises low density polyethylene (LDPE).

9. An ingestible capsule as claimed in claim 1, wherein the foil is covered with Polychlorotrifluorethylene (PFTE).

10. An ingestible capsule as claimed in claim 1, wherein the heating wire is a printed electrically conducting trace.

11. An ingestible capsule as claimed in claim 1, wherein the indicator trace is electrically connected to the electronics.

12. An ingestible capsule as claimed in claim 1, wherein the first module comprises more than one drug compartment for comprising the amount of the drug, each drug compartment being sealed by a separate foil with an embedded conducting heating wire, the first conductive element being arranged for separately coupling each one of the heating wires to the electronics.

13. An ingestible capsule for delivery of a drug, the capsule comprising:

a first module comprising;

a first sidewall comprising an outer surface of the first module and defining a drug compartment,

a window formed as an opening through the first sidewall;

a polymer foil covering the window to prevent drug in the drug compartment from exiting through the window,

a metallic conducting heating wire embedded in the polymer foil,

a first connector at a termination of the first sidewall, and

a first conductive element disposed on the first connector and electrically connected to the conducting heating wire, and

a second module comprising;

a second sidewall comprising an outer surface of the second module and defining a volume,

a power source disposed in the volume;

electronics in the volume and in communication with the power source,

a second connector at a termination of the second sidewall and configured to cooperate with the first connector to secure the second module to the first module, and

a second conductive element disposed on the second connector and electrically connected to the power source,

wherein cooperation of the first connector with the second connector to secure the second module to the first module electrically connects the first conductive element and the second conductive element to electrically couple the heating wire to the electronics.

14. The ingestible capsule of claim 13, wherein the first connector is a first sliding contact upon which the first conductive element is disposed and the second connector is a second sliding contact upon which the second conductive element is disposed.

15. The ingestible capsule of claim 13, wherein the first connector is a first thread, the second connector is a second thread, the first conductive element is disposed in the first thread, and the second conductive element is disposed in the second thread.

16. The ingestible capsule of claim 13, further comprising an indicator trace positioned orthogonal to the heating wire.

17. The ingestible capsule of claim 13, the first module further comprising a lid proximate the termination of the sidewall to seal the drug compartment.

18. An ingestible capsule for delivery of a drug, the capsule comprising:

a first module comprising;

a sidewall defining an internal volume

a separation wall separating the internal volume into a first drug compartment and a second drug compartment,

a first window formed as an opening through the sidewall proximate the first drug compartment, placing the first drug compartment in fluid communication with an exterior of the capsule,

a second window formed as an opening through the sidewall proximate the second drug compartment, placing the second drug compartment in fluid communication with the exterior of the capsule;

a first foil covering the first window to seal the first drug compartment,

first conducting heating wire contacting the first foil,

a second foil covering the second window to seal the second drug compartment,

a second conducting heating wire contacting the second foil,

at least one first conductive element electrically connected to at least one of the first conducting heating wire or the second conducting heating wire,

an indicator conducting trace across the first conducting heating wire; and

a second module comprising;

a power source;

electronics in communication with the power source for controlling an electrical pulse, and

at least one second conductive element electrically connected to the power source,

wherein securing the first module to the second module electrically connects the first conductive element and the second conductive element to electrically couple the first and second conducting heating wires to the electronics, and

wherein the first conducting heating wire is configured to break the first foil with an applied current and breaking the first foil causes the indicator conducting trace to open at the portion extending across the first conducting heating wire, the opening of the indicator conducting trace indicating that the first conducting heating wire has broken the first foil.

19. The ingestible capsule of claim 18, the first module further comprising a lid disposed in an axial opening proximate a termination of the sidewall to seal the drug compartments.