Medicament application adapter comprising a gas blocking element for a hemodialysis tube set
First Claim
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1. A medical device for introduction of a liquid medicament stored in an injection vial into an extracorporeal blood circuit of a haemodialysis machine during operation thereof, said device comprising:
- a gas reservoir for storing a gas, wherein pressure in said gas reservoir is selectable to regulate liquid medicament flow rate into the extracorporeal blood circuit and a period of time over which the liquid medicament in the injection vial is administered into the extracorporeal blood circuit, and wherein a pressure in said gas reservoir is greater than a pressure in conduit pathways of the extracorporeal blood circuit at an addition site;
a piercing structure for opening the injection vial, said piercing structure having a first conduit pathway and a second conduit pathway,a first end of said first conduit pathway opening into an interior of the injection vial when said piercing structure has been inserted to penetrate fully into the interior of the injection vial,a second end of said first conduit pathway being joined to the conduit pathways of the extracorporeal blood circuit of the haemodialysis machine at the addition site,a first end of said second conduit pathway opening into the interior of the injection vial when said piercing structure has been inserted to penetrate fully into the interior of the injection vial,a second end of said second conduit pathway being connected with said gas reservoir so that gas held in said gas reservoir is able to flow into the interior of the injection vial via the second conduit pathway,a gas-blocking filter element being arranged in said first conduit pathway, said gas-blocking filter element configured to block passage of gases therethrough while allowing the liquid medicament from said injection vial to pass through the gas-blocking filter element and into the extracorporeal blood circuit of the haemodialysis machine at the addition site via said first conduit pathway, said gas-blocking filter element having a filter area and pore size dimensioned to create a desired flow resistance that, in cooperation with a selected pressure in said gas reservoir, is effective to regulate the liquid medicament flow rate from the injection vial to the extracorporeal blood circuit by increasing or decreasing the liquid medicament flow rate through said gas-blocking element so as to administer a greater or lesser quantity, respectively, of the liquid medicament to the extracorporeal blood circuit per unit of time during operation of the haemodialysis machine;
a venous drip chamber;
a first pressure measuring device that determines a pressure of the gas in said venous drip chamber; and
a second pressure measuring device that determines a pressure of the gas in thesaid gas reservoir,wherein the pressure in said gas reservoir is selected based on a pressure difference determined by a comparison the pressure of the gas in said venous drip chamber with the pressure of the gas in said gas reservoir, and wherein the selected pressure is that which is required to regulate the liquid medicament flow rate into the extracorporeal blood circuit without the pressure difference exceeding a bubble pressure of said gas-blocking filter element.
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Abstract
For the administering of medicaments, an adapter is provided for connection to a haemodialysis tube set, which makes possible the direct connection of a standard injection vial to the extracorporeal circuit, avoiding the introduction of air into the circuit. The adapter has two conduit pathways. The conduit pathway for the application of medicament contains a gas-blocking element. The second conduit pathway serves for the aeration of the injection vial.
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Citations
22 Claims
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1. A medical device for introduction of a liquid medicament stored in an injection vial into an extracorporeal blood circuit of a haemodialysis machine during operation thereof, said device comprising:
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a gas reservoir for storing a gas, wherein pressure in said gas reservoir is selectable to regulate liquid medicament flow rate into the extracorporeal blood circuit and a period of time over which the liquid medicament in the injection vial is administered into the extracorporeal blood circuit, and wherein a pressure in said gas reservoir is greater than a pressure in conduit pathways of the extracorporeal blood circuit at an addition site; a piercing structure for opening the injection vial, said piercing structure having a first conduit pathway and a second conduit pathway, a first end of said first conduit pathway opening into an interior of the injection vial when said piercing structure has been inserted to penetrate fully into the interior of the injection vial, a second end of said first conduit pathway being joined to the conduit pathways of the extracorporeal blood circuit of the haemodialysis machine at the addition site, a first end of said second conduit pathway opening into the interior of the injection vial when said piercing structure has been inserted to penetrate fully into the interior of the injection vial, a second end of said second conduit pathway being connected with said gas reservoir so that gas held in said gas reservoir is able to flow into the interior of the injection vial via the second conduit pathway, a gas-blocking filter element being arranged in said first conduit pathway, said gas-blocking filter element configured to block passage of gases therethrough while allowing the liquid medicament from said injection vial to pass through the gas-blocking filter element and into the extracorporeal blood circuit of the haemodialysis machine at the addition site via said first conduit pathway, said gas-blocking filter element having a filter area and pore size dimensioned to create a desired flow resistance that, in cooperation with a selected pressure in said gas reservoir, is effective to regulate the liquid medicament flow rate from the injection vial to the extracorporeal blood circuit by increasing or decreasing the liquid medicament flow rate through said gas-blocking element so as to administer a greater or lesser quantity, respectively, of the liquid medicament to the extracorporeal blood circuit per unit of time during operation of the haemodialysis machine; a venous drip chamber; a first pressure measuring device that determines a pressure of the gas in said venous drip chamber; and a second pressure measuring device that determines a pressure of the gas in thesaid gas reservoir, wherein the pressure in said gas reservoir is selected based on a pressure difference determined by a comparison the pressure of the gas in said venous drip chamber with the pressure of the gas in said gas reservoir, and wherein the selected pressure is that which is required to regulate the liquid medicament flow rate into the extracorporeal blood circuit without the pressure difference exceeding a bubble pressure of said gas-blocking filter element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A medical device for introducing a liquid medicament contained in an injection vial into an extracorporeal blood circuit of a haemodialysis machine during operation thereof, said device comprising
a gas reservoir for storing a gas, wherein said gas reservoir is acted upon by pressure that enables a particular pressure in said gas reservoir to be set to control a liquid medicament flow rate from the injection vial into the extracorporeal blood circuit during operation of the haemodialysis machine, and wherein pressure in said gas reservoir is greater than a pressure in conduit pathways of the extracorporeal blood circuit at an addition site; -
a piercing structure for opening the injection vial, said piercing structure having a first conduit pathway and a second conduit pathway, a first end of said first conduit pathway and a first end of the second conduit pathway opening into an interior of the injection vial when said piercing structure has been inserted to penetrate fully into the interior of the injection vial, a second end of said first conduit pathway being joined to the conduit pathways of the extracorporeal blood circuit of the haemodialysis machine at the addition site, a second end of said second conduit pathway being in fluid communication with said gas reservoir so that gas held in the gas reservoir is able to flow into the interior of the injection vial via the second conduit pathway, a gas-blocking element configured to block passage of gases therethrough while, at the same time, allowing the liquid medicament flowing through said first conduit pathway from said injection vial to pass through said gas-blocking element and into the extracorporeal blood circuit of the haemodialysis machine under the pressure of the gas that flows from said gas reservoir into the interior of the injection vial via said second conduit pathway, wherein said gas-blocking element forms a flow resistance that, in cooperation with the particular pressure set in the gas reservoir, is effective to administer a particular quantity of the liquid medicament from the injection vial into the extracorporeal blood circuit per unit of time during operation of the haemodialysis machine; a venous drip chamber; a first pressure measuring device that determines a pressure of the gas in the venous drip chamber; and a second pressure measuring device that determines a pressure of the gas in the gas reservoir, wherein the pressure in the gas reservoir is selected based on a pressure difference determined by a comparison of the pressure of the gas in said venous drip chamber with the pressure of the gas in said gas reservoir so as to regulate the liquid medicament flow rate into the extracorporeal blood circuit without the pressure difference exceeding a bubble pressure of the gas-blocking filter element while taking into account a pore size and filter area of said gas-blocking element so as to effect different liquid medicament flow rates through said gas-blocking element and into the extracorporeal blood circuit and to regulate a corresponding period of time over which the liquid medicament in the injection vial is administered into the extracorporeal blood circuit for each of said different liquid medicament flow rates through said gas-blocking element. - View Dependent Claims (18, 19, 20)
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21. A device for regulated introduction of a liquid medicament, said device comprising:
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an injection vial containing the liquid medicament; a venous drip chamber, the venous drip chamber having a first pressure measuring device that determines a pressure of a gas therein; a gas reservoir containing the gas, the gas reservoir having a second pressure measuring device that determines a pressure of the gas therein; a piercing structure for opening said injection vial; and a gas-blocking filter element; a pressure of the gas in the gas reservoir being selectable to regulate a liquid medicament flow rate, said piercing structure having a first conduit pathway and a second conduit pathway, a first end of said first conduit pathway opening into an interior of the injection vial, a second end of said first conduit pathway being joined to conduit pathways at a liquid medicament introduction site for haemodialysis, a first end of the second conduit pathway opening into said interior of said injection vial, and a second end of said second conduit pathway being connected with said gas reservoir, said gas-blocking filter element being arranged in said first conduit pathway and being configured to block passage of the gas therethrough while allowing passage of the liquid medicament therethrough, said gas-blocking filter element having a filter area and pore size dimensioned to provide a desired flow resistance that, in cooperation with said selected pressure of the gas in the gas reservoir, is effective to regulate the liquid medicament flow rate from said injection vial to the introduction site, wherein, the pressure of the gas reservoir is selected based on a pressure difference determined by comparison of the pressure of the gas in the venous drip chamber with the pressure of the gas in the gas reservoir so as to determine the pressure of the gas in the gas reservoir that is required to regulate the liquid medicament flow rate without the pressure difference exceeding a bubble pressure of the gas-blocking filter element. - View Dependent Claims (22)
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Specification