Device for a biological liquid treatment installation

• US 9,744,487 B2
• Filed: 09/23/2014
• Issued: 08/29/2017
• Est. Priority Date: 06/08/2010
• Status: Active Grant

• Current Assignee: EMD Millipore Corporation (Merck & Co., Inc.)
• Original Assignee: EMD Millipore Corporation (Merck & Co., Inc.)
• Inventors: Cirou, Sebastien, Reinbigler, Rene, Buisson, Virginie, Weissenbach, Jean-Louis
• Primary Examiner(s): DRODGE, JOSEPH W
• Application Number:
  US14/493,678
• Publication Number:
  US 20150008184A1
• Time in Patent Office: 1,071 Days
• Field of Search: 210645, 210646, 210650, 210739, 210741, 210767, 210 85, 210 90, 210 961, 210134, 210232, 210241, 2101982, 2103216, 210541, 210542, 435183, 435243, 435260, 435261, 4352831, 4352861, 4352865, 4352867, 4352971, 4352982, 4352973, 4352974, 4352975, 4353071, 4353081, 137343, 137377, 137571, 137561, 137572, 16231, 16232, 16277, 100 99, 100102, 100144, 100 90, 100211, 422501, 422527, 422537, 422 70, 422544, 422547, 422555, 422565, 220200, 220241, 220242, 220243, 220244, 220810, 220845, 220660, 220661
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: B01D 15/08 Selective adsorption, e.g. chromatography
• CPC Class Codes: B01D 2313/105 Supply manifolds
• CPC Class Codes: B01D 2313/125 Discharge manifolds
• CPC Class Codes: B01D 2313/18 Specific valves
• CPC Class Codes: B01D 2313/58 Parts of membrane modules specifically adapted for single use
• CPC Class Codes: B01D 33/00 Filters with filtering elements which move during the filtering operation filters comprising loose filtering material moving or fluidised during filtration B01D24/28 - B01D24/36; centrifuges B04B
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 61/20 Accessories; Auxiliary operations
• CPC Class Codes: C12M 47/12 Purification C12M47/04 takes precedence
• CPC Class Codes: F04B 43/08 having tubular flexible members F04B43/12 takes precedence
• CPC Class Codes: Y10T 137/8593 Systems
• CPC Class Codes: Y10T 137/86187 Plural tanks or compartments connected for serial flow
• CPC Class Codes: Y10T 137/86196 Separable with valved-connecting passage

Abstract

The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first she (16) disposed on a front face (5) of said base (2) and a second shed (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20).

Claims

1. A method of treating biological fluids, comprising:

providing a device comprising;

a base having a front face;

a moveable or removable door, said device having a closed door position;

in the closed door position, a circuit comprising a plurality of connectors and a network for conveying liquid between said connectors, which circuit comprises a bag comprising two flexible films and said conveying network connectors, which circuit further comprises a press comprising a first shell disposed on said front face of said base and a second shell disposed in said door; and

a hinge system hinging said door relative to said base, said hinge system being disposed only on one side of said door so as to form, in the closed door position, lateral clearances between said door and said base over the rest of a perimeter of said door, so as to enable free access to the connectors of said bag;

connecting at least one of said connectors to a source of said biological fluid;

connecting at least one of said connectors to a treatment component; and

introducing said biological fluid into said device.

2. The method of claim 1, further comprising inflating said bag, causing a first of said two flexible films to conform to the face of said first shell and the second of said two flexible films to conform to the face of said second shell.

3. The method of claim 1, further comprising:

disconnecting said source of said biological fluid and said treatment component from said connectors;

removing said bag from said device; and

connecting a second bag to said source of biological fluid and to a second treatment component.

4. The method of claim 1, wherein the step of connecting said at least one of said connectors to said treatment component comprises connecting said at least one of said connectors to a treatment component that comprises valves to allow or prevent the passage of said liquid in said conduits.

5. The method of claim 1, wherein the step of connecting said at least one of said connectors to said treatment component comprises connecting said at least one of said connectors to a treatment component that comprises sensors of physicochemical values of said liquid connectable in said circuit to be in fluid communication with said biological fluids.

6. The method of claim 1, wherein, in the closed door position, said bag is clamped between the first and second shells in a state in which conduits of said network for conveying liquid are formed between said films.