Pipette tip washing device

• US 9,744,570 B2
• Filed: 07/10/2015
• Issued: 08/29/2017
• Est. Priority Date: 04/30/2013
• Status: Active Grant

• Current Assignee: Grenova, Inc.
• Original Assignee: Grenova, LLC
• Inventors: Safavi, Ali
• Primary Examiner(s): Chaudhry, Saeed T
• Application Number:
  US14/796,712
• Publication Number:
  US 20150314341A1
• Time in Patent Office: 781 Days
• CPC Class Codes: A47L 15/4242 by using ultraviolet generators
• CPC Class Codes: A61L 2/10 Ultraviolet radiation
• CPC Class Codes: B01L 13/02 for receptacle or instruments
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 2400/0605 check valves
• CPC Class Codes: B01L 3/0275 Interchangeable or disposable dispensing tips
• CPC Class Codes: B08B 3/00 Cleaning by methods involving the use or presence of liquid or steam B08B9/00 takes precedence
• CPC Class Codes: B08B 3/12 by sonic or ultrasonic vibrations washing or rinsing machines for crockery or tableware using sonic or ultrasonic waves A47L15/13; of natural teeth, of prostheses using ultrasonic techniques similar to those used for natural teeth A61C17/20; application of ultrasonic vibrations to chemical, physical or physico-chemical processes in general B01J19/10
• CPC Class Codes: B08B 7/0057 by ultraviolet radiation
• CPC Class Codes: B08B 9/0321 using pressurised, pulsating or purging fluid E04F17/126 takes precedence
• CPC Class Codes: G01N 35/1004 Cleaning sample transfer devices

Abstract

A washing device comprises a fluid dispenser that operably directs a cleaning fluid to contact one or more objects to be cleaned, the one or more objects to be cleaned being contained by the washing device, a dispensing line directing the cleaning fluid to the fluid dispenser, a compressed air source, an air valve selectively controlling flow of air from the compressed air source into the dispensing line, a cleaning fluid source, a pump selectively pumping the cleaning fluid from the cleaning fluid source into the dispensing line, and a controller. The controller alternatingly activates (a) the pump to pump the cleaning fluid from the cleaning fluid source into the dispensing line and (b) the air valve to force the cleaning fluid from the dispensing line via the fluid dispenser.

Claims

1. A washing device comprising:

a fluid dispenser that operably directs a cleaning fluid to contact one or more objects to be cleaned, the one or more objects to be cleaned being contained by the washing device, the fluid dispenser comprising a manifold dispenser;

a dispensing line directing the cleaning fluid to the fluid dispenser;

a compressed air source;

an air valve selectively controlling flow of air from the compressed air source into the dispensing line;

a cleaning fluid source;

a pump selectively pumping the cleaning fluid from the cleaning fluid source into the dispensing line;

a controller for alternatingly activating (a) the pump to pump the cleaning fluid from the cleaning fluid source into the dispensing line and (b) the air valve to force the cleaning fluid from the dispensing line via the fluid dispenser;

a top compartment capable of receiving the manifold dispenser, wherein the manifold dispenser comprises at least one liquid input and a plurality of liquid outputs that operably direct the cleaning fluid to contact a plurality of laboratory consumables held by a rack;

a middle compartment positioned below the top compartment and comprising a washing chamber capable of receiving fluid output by the plurality of liquid outputs of the manifold dispenser, the washing chamber having a floor comprising a material transparent to ultraviolet (UV) light; and

a bottom compartment positioned below the washing chamber, the bottom compartment having a light source mounted thereto, wherein the light source is capable of outputting UV light in the direction of the washing chamber and through the floor of the washing chamber.

2. The washing device of claim 1, further comprising:

a one-way valve downstream from the pump to prevent the cleaning fluid from flowing upstream toward the pump.

3. The washing device of claim 1, wherein the controller activates the pump at least until the dispensing line is filled with the cleaning fluid.

4. The washing device of claim 1, wherein the controller activates the air valve at least until substantially all of the cleaning fluid in the dispensing line is forced from the dispensing line via the fluid dispenser.

5. The washing device of claim 1, wherein the rack comprises a tip rack and the plurality of laboratory consumables comprise a plurality of pipette tips.

6. The washing device of claim 5, wherein the tip rack is configured to hold 24, 48, 96, 384, or 1536 pipette tips.

7. The washing device of claim 1, wherein the washing chamber is capable of retaining liquid output by the plurality of liquid outputs such that the liquid cannot enter the bottom compartment.

8. The washing device of claim 1, wherein the washing chamber further comprises a waste drain operable to dispense retained liquid from the wash chamber.

9. The washing device of claim 1, wherein the top compartment is further capable of receiving a plurality of manifold dispensers.

10. The washing device of claim 1, wherein the material transparent to UV light comprises quartz glass.

11. The washing device of claim 1, further comprising a plurality of fiber optic channels extending through the manifold dispenser at each of the plurality of liquid outputs.

12. The washing device of claim 11, wherein the light source is further coupled to the plurality of fiber optic channels.

13. The washing device of claim 11, wherein the plurality of liquid outputs each comprise a nozzle having an opening into which one of the plurality of fiber optic channels extends.

14. The washing device of claim 1, wherein the wash compartment is further configured to removably receive a wash sleeve, the wash sleeve comprising a material capable of reflecting at least a portion of the UV light output by the light source.

15. The washing device of claim 1, wherein the washing chamber has a plurality of walls and one or more of the plurality of walls comprise a material transparent to ultraviolet (UV) light.

16. The washing device of claim 15, wherein the middle compartment includes one or more additional light sources mounted thereto and proximate to one or more of the plurality of walls of the washing chamber, wherein the one or more additional light sources are capable of outputting UV light in the direction of the washing chamber and through one or more of the plurality of walls of the washing chamber.

17. The washing device of claim 1, further comprising one or more transducers capable of outputting sound in an ultrasonic range into the washing chamber.

18. A method for washing laboratory consumables, comprising:

(i) loading one or more objects to be cleaned into a washing device, the washing device comprising;

a fluid dispenser that operably directs a cleaning fluid to contact the one or more objects to be cleaned, the fluid dispenser comprising a manifold dispenser;

a dispensing line for directing the cleaning fluid to the fluid dispenser

a compressed air source;

an air valve for selectively controlling flow of air from the compressed air source into the dispensing line;

a cleaning fluid source;

a pump for selectively pumping the cleaning fluid from the cleaning fluid source into the dispensing line; and

a controller;

(ii) alternatingly activating, via the controller (a) the pump to pump the cleaning fluid from the cleaning fluid source into the dispensing line and (b) the air valve to force the cleaning fluid from the dispensing line via the fluid dispenser;

(iii) directing the cleaning fluid to contact a plurality of laboratory consumables held by a rack, the directing comprising introducing the cleaning fluid into a fluid input and out of a plurality of fluid outputs of the manifold dispenser;

(iv) draining the cleaning fluid via a waste drain disposed proximate to a washing chamber configured to receive the cleaning fluid following the contact by the cleaning fluid with the plurality of laboratory consumables;

(v) substantially drying the plurality of laboratory consumables; and

(vi) exposing the plurality of laboratory consumables to light in an ultraviolet (UV) range, the exposing comprising illuminating a light source to direct the light in the UV range through one or more of a UV transparent floor or one or more walls of the washing chamber.

19. The method of claim 18, wherein the washing device further comprises:

a one-way valve downstream from the pump to prevent the cleaning fluid from flowing upstream toward the pump.

20. The method of claim 18, wherein activating the pump comprises activating the pump at least until the dispensing line is filled with the cleaning fluid.

21. The method of claim 18, wherein activating the air valve comprises activating the air valve at least until substantially all of the cleaning fluid in the dispensing line is forced from the dispensing line via the fluid dispenser.

22. The method of claim 18, further comprising substantially submerging the plurality of laboratory consumables in the cleaning fluid prior to draining the cleaning fluid from the waste drain.

23. The method of claim 18, wherein the directing further comprising at least one of washing or rinsing the plurality of laboratory consumables with at least two liquid solutions prior to exposing the plurality of laboratory consumables to the light in the UV range, the cleaning fluid comprising one of the at least two liquid solutions.

24. The method of claim 18, wherein the cleaning fluid comprises one or more of deionized water, bleach, hydrogen peroxide, one or more enzyme solutions, ethanol, detergent, purified water, water, ammonia, isopropanol, alcohol, a solution capable of substantially rinsing or decontaminating plastic, or combinations thereof.

25. The method of claim 18, wherein the exposing further comprises exposing at least an interior portion of the each of the plurality of laboratory consumables to the light in the UV range via a plurality of fiber optic channels extending from the manifold into the plurality of fluid outputs.

26. The method of claim 25, wherein the exposing further comprises introducing the light in the UV range into the plurality of fiber optic channels directly from the light source.

27. The method of claim 25, wherein the exposing comprises exposing both an interior and an exterior portion of each of the plurality of laboratory consumables to the light in the UV range.

28. The method of claim 18, wherein the directing further comprises directing the cleaning fluid to contact a plurality of laboratory consumables held by a plurality of racks and wherein the plurality of laboratory consumables comprise pipette tips.

29. The method of claim 18, further comprising exposing the plurality of laboratory consumables to sound in an ultrasonic range, the exposing comprising energizing one or more transducers to direct the sound in the ultrasonic range into the washing chamber.

30. The method of claim 18, further comprising agitating the plurality of laboratory consumables.