Irreversible covalent inhibitors of the GTPase K-Ras G12C
2 Assignments
0 Petitions
Accused Products
Abstract
Irreversible inhibitors of K-Ras, H-Ras or N-ras protein comprising a G12C mutation are provided. Also disclosed are methods to regulate the activity of K-Ras, H-Ras or N-ras protein comprising G12C mutation and methods to disease mediated by K-Ras, H-Ras or N-ras G12C.
-
Citations
11 Claims
- 1. A compound of Formula I:
Specification