Flap modulators

• US 9,745,328 B2
• Filed: 01/31/2014
• Issued: 08/29/2017
• Est. Priority Date: 02/04/2013
• Status: Active Grant

• Current Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Original Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Inventors: Bacani, Genesis M., Eccles, Wendy, Fitzgerald, Anne E., Goldberg, Steven D., Hack, Michael D., Hawryluk, Natalie A., Jones, William M., Keith, John M., Krawczuk, Paul, Lebsack, Alec D., Lee-Dutra, Alice, Liu, Jing, McClure, Kelly J., Meduna, Steven P., Pippel, Daniel J., Rosen, Mark D., Sales, Zachary S.
• Primary Examiner(s): Shterengarts, Samantha
• Assistant Examiner(s): MAURO, JOHN MATTHEW
• Application Number:
  US14/765,556
• Publication Number:
  US 20150376212A1
• Time in Patent Office: 1,306 Days
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/06 Antigout agents, e.g. antihyperuricemic or uricosuric agents
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 209/08 : with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 213/73 : Unsubstituted amino or imino radicals
• CPC Class Codes: C07D 235/10 : Radicals substituted by halogen atoms or nitro radicals
• CPC Class Codes: C07D 237/20 : Nitrogen atoms nitro radicals C07D237/12
• CPC Class Codes: C07D 241/20 : Nitrogen atoms nitro radicals C07D241/16
• CPC Class Codes: C07D 241/26 : with nitrogen atoms directly attached to ring carbon atoms
• CPC Class Codes: C07D 263/48 : Nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 277/62 : Benzothiazoles
• CPC Class Codes: C07D 285/12 : 1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
• CPC Class Codes: C07D 401/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 401/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 401/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 : containing three or more hetero rings
• CPC Class Codes: C07D 403/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 403/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 403/14 : containing three or more hetero rings
• CPC Class Codes: C07D 405/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/14 : containing three or more hetero rings
• CPC Class Codes: C07D 409/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 413/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/14 : containing three or more hetero rings
• CPC Class Codes: C07D 417/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems
• CPC Class Codes: C07D 487/04 : Ortho-condensed systems
• CPC Class Codes: C07D 487/08 : Bridged systems
• CPC Class Codes: C07D 491/08 : Bridged systems
• CPC Class Codes: C07D 491/10 : Spiro-condensed systems
• CPC Class Codes: C07D 491/107 : with only one oxygen atom as ring hetero atom in the oxygen-containing ring
• CPC Class Codes: C07D 495/10 : Spiro-condensed systems
• CPC Class Codes: C07D 498/04 : Ortho-condensed systems
• CPC Class Codes: C07F 5/025 : Boronic and borinic acid compounds
• CPC Class Codes: C07F 7/08 : Compounds having one or more C—Si linkages
• CPC Class Codes: C07F 7/0812 : comprising a heterocyclic ring

Abstract

The present invention relates to compounds of Formula (I), or a form thereof wherein ring A₁, R₁, R₂, R₃, R₃′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

Claims

1. A compound of Formula (I)

2. The compound of claim 1, wherein

L is a bond, —

O—

, —

SO₂—

NH—

, —

NH—

SO₂—

, —

SO₂—

, —

S—

, —

C(═

O)—

, fluoro or —

C(═

O)—

NH—

;

R₁ is H, bromo or CF₃;

R₂ is H, methyl, ethyl, propyl, isopropyl, tert-butyl, cyclopropyl, cyclohexyl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, piperazin-1-yl, tetrahydro-2H-thiopyran-4-yl, morpholin-2-yl, morpholin-4-yl, thiomorpholin-4-yl, pyrazin-2-yl, pyrimidin-2-yl, or pyrimidin-4-yl, provided R₂ is not H if L is a bond, and wherein R₂ is optionally substituted with hydroxyl, fluoro, amino, oxo, methyl, or —

CH₂—

NH₂;

V is CH or N;

W is CR″

or N, wherein R″

is H or F;

ring A is

3. The compound of claim 1, wherein

L is a bond, —

O—

, —

SO₂—

NH—

, —

NH—

SO₂—

, —

SO₂—

, —

S—

, or —

C(═

O)—

;

R₁ is H or CF₃;

R₂ is H, methyl, ethyl, propyl, isopropyl, tert-butyl, cyclopropyl, cyclohexyl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, piperazin-1-yl, tetrahydro-2H-thiopyran-4-yl, morpholin-2-yl, morpholin-4-yl, thiomorpholin-4-yl, pyrazin-2-yl, pyrimidin-2-yl, or pyrimidin-4-yl, provided R₂ is not H if L is a bond, and wherein R₂ is optionally substituted with hydroxyl, fluoro, amino, oxo, methyl, or —

CH₂—

NH₂;

V is CH or N;

W is CR″

or N, wherein R″

is H or F;

ring A is

4. The compound of claim 1, wherein the compound is selected from:

5-(3-fluoro-2′

-(methylsulfonyl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methanesulfonamide,

6-Amino-3-[3-fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazine-2-carbonitrile,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-cyclohexyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-methylpropyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1-methylethyl)biphenyl-2-sulfonamide (racemic),

4′

-(5-Aminopyrazin-2-yl)-N-(cyclobutylmethyl)-3′

-fluorobiphenyl-2-sulfonamide,

(endo)-4′

-(5-Aminopyrazin-2-yl)-N-bicyclo[2.2.1]hept-2-yl-3′

-fluorobiphenyl-2-sulfonamide (racemic),

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-methylcyclobutyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-(1,1-dimethylpropyl)-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1,1-dimethylethyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-cyclopentyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-ethyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-phenylethyl)biphenyl-2-sulfonamide,

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide,

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide,

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-(2,3-dihydro-1H-inden-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

(S)-4′

-(5-Aminopyrazin-2-yl)-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-3′

-fluorobiphenyl-2-sulfonamide,

(R)-4′

-(5-Aminopyrazin-2-yl)-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-3′

-fluorobiphenyl-2-sulfonamide,

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-1-phenylethyl]biphenyl-2-sulfonamide,

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-phenylbiphenyl-2-sulfonamide,

(S)-4′

-(5-Aminopyrazin-2-yl)-N-[(3S)-1-ethyl-2-oxoazepan-3-yl]-3′

-fluorobiphenyl-2-sulfonamide,

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(3S)-2-oxoazepan-3-yl]biphenyl-2-sulfonamide,

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(3S)-1-methyl-2-oxoazepan-3-yl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1,2,2,6,6-pentamethylpiperidin-4-yl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-pyridin-3-ylbiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfamide,

N-(4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1, 1′

-biphenyl]-2-yl)propane-2-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]ethanesulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]propane-1-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-2-methylpropane-1-sulfonamide,

N-(4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)cyclopropanesulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]hexane-1-sulfonamide,

N-(4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)cyclobutanesulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1,1,1-trifluoromethanesulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N,N-dimethylbiphenyl-2-sulfonamide,

5-[3-Fluoro-2′

-(piperidin-1-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(morpholin-4-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-[3-Fluoro-2′

-(piperazin-1-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-sulfonamide,

5-[3-Fluoro-2′

-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-{2′

-[(4,4-Difluoropiperidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(3,3-Difluoropiperidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(3,3-Difluoropyrrolidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(3,3-Difluoroazetidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-[2′

-(Azepan-1-ylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-{3-Fluoro-2′

-[(4-methylpiperazin-1-yl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-(trifluoromethyl)piperidin-4-ol,

5-(3-Fluoro-2′

-{[4-(methylsulfonyl)piperazin-1-yl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine,

5-{2′

-[(4-Acetylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-(2′

-{[4-(Cyclopropylcarbonyl)piperazin-1-yl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine,

2-(4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-1-yl)ethanol,

5-{2′

-[(4-Cyclopropylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

racemic 5-[3-Fluoro-2′

-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-{2′

-[(3,5-Dimethylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

racemic 1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidine-3-carbonitrile,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidine-4-carbonitrile,

5-{2′

-[(4-Aminopiperidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-2-one,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-ol,

(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)methanol,

2-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)ethanol,

racemic 1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-ol,

racemic 2-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)ethanol,

5-(3-Fluoro-2′

-{[4-(methylamino)piperidin-1-yl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine,

5-(2′

-{[4-(Dimethylamino)piperidin-1-yl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine,

racemic 5-{2′

-[(3-Aminopiperidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

N-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)acetamide,

racemic (1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)methanol,

racemic tert-Butyl (1-{[4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)carbamate,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S,2S)-2-hydroxy-1-(hydroxymethyl)-2-phenylethyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxypropyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-phenylethyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-phenylethyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R,2R)-2-hydroxycyclohexyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-1-(hydroxymethyl)propyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R,2S)-2-hydroxycyclohexyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-(cyclopropylmethyl)-3′

-fluorobiphenyl-2-sulfonamide,

(R)-(1-((4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)pyrrolidin-2-yl)methanol,

(R)-5-(2′

-((3-aminopyrrolidin-1-yl)sulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

(S)-5-(2′

-((3-aminopyrrolidin-1-yl)sulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

(R) 5-(2′

-{[2-(Aminomethyl)pyrrolidin-1-yl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine,

(S)-(1-((4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)pyrrolidin-2-yl)methanol,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(methylsulfonyl)biphenyl-2-sulfonamide,

(R)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxypropyl)-[1,1′

-biphenyl]-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxypropyl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1-hydroxycyclohexyl)methyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxy-1,1-dimethylethyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxy-2-methylpropyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxy-1,1-dimethylpropyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxy-2,2-dimethylpropyl)biphenyl-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-N-(2,3-dihydroxypropyl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

(R)-4′

-(5-aminopyrazin-2-yl)-N-(2,3-dihydroxypropyl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

(trans)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3,4-diol,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(2-oxopyrrolidin-3-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(2-oxopiperidin-3-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[1-(hydroxymethyl)-2-methylpropyl]biphenyl-2-sulfonamide,

trans 4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl)biphenyl-2-sulfonamide,

(R)-(1-((4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)pyrrolidin-3-yl)methanol,

(S)-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-3-yl)methanol,

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-oxopiperidin-3-yl)biphenyl-2-sulfonamide,

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methyl-N-piperidin-3-ylbiphenyl-2-sulfonamide,

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methyl-N-piperidin-3-ylbiphenyl-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3-phenylpropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(R)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxy-2-phenylethyl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-[1,1′

-biphenyl]-2-sulfonamide,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}azetidin-3-ol,

racemic (trans)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxycyclohexyl)biphenyl-2-sulfonamide,

racemic (trans)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[2-(hydroxymethyl)cyclohexyl]biphenyl-2-sulfonamide,

racemic (cis)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[2-(hydroxymethyl)cyclohexyl]biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-piperidin-4-ylbiphenyl-2-sulfonamide,

5-(2′

-{[3-(Aminomethyl)azetidin-1-yl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-(azetidin-3-ylmethyl)-3′

-fluorobiphenyl-2-sulfonamide,

(R)-5-(3-Fluoro-2′

-{[3-(methylamino)pyrrolidin-1-yl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine,

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1-methylethyl)biphenyl-2-sulfonamide,

5-[3-Fluoro-2′

-(1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

4-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one,

5-(2′

-((1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

5-(2′

-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(5-hydroxypentyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(6-hydroxyhexyl)biphenyl-2-sulfonamide,

N-(4-Aminocyclohexyl)-4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

(S)-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2,3-dihydro-1H-indol-2-yl)methanol,

4′

-(5-Aminopyrazin-2-yl)-N-cyclohexyl-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide,

(S)-5-{2′

-[(3-Aminopiperidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N,N-bis(2-hydroxyethyl)biphenyl-2-sulfonamide,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}azetidine-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-N-cyclopropyl-3′

-fluoro-N-(tetrahydro-2H-pyran-4-yl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)-N-(1-methylethyl)biphenyl-2-sulfonamide,

racemic (4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}morpholin-2-yl)methanol,

(1R,5S)-3-((4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)-3-azabicyclo[3.1.0]hexan-6-amine,

(S)-5-(3-fluoro-2′

-((2-methylpiperazin-1-yl)sulfonyl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

(R)-5-(3-fluoro-2′

-((2-methylpiperazin-1-yl)sulfonyl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

(R)-(1-((4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperazin-2-yl)methanol,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]biphenyl-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3-methyl butan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(R)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

tert-Butyl [2-({[4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}amino)ethyl]carbamate,

N-(2-Aminoethyl)-4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxybutan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(pyrrolidin-3-yl)-[1,1′

-biphenyl]-2-sulfonamide,

N-[2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}amino)ethyl]acetamide,

(S)-2-(4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-ylsulfonamido)propanoic acid,

4′

-(5-Aminopyrazin-2-yl)-N-[2-(carbamoylamino)ethyl]-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-((1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-((1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-((1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-((1S,2S)-2-hydroxycyclohexyl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[6-(trifluoromethyl)pyridin-3-yl]biphenyl-2-sulfonamide,

5-(3-Fluoro-2′

-{[4-(1H-imidazol-4-yl)piperidin-1-yl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine,

N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-(2,6-dimethoxypyrimidin-4-yl)-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(5-methylpyrazin-2-yl)biphenyl-2-sulfonamide,

(S)-2-(4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-ylsulfonamido)-4-methylpentanamide,

4′

-(5-Aminopyrazin-2-yl)-N-(2-cyanoethyl)-3′

-fluorobiphenyl-2-sulfonamide,

(R)-4′

-(5-aminopyrazin-2-yl)-N-(1-cyanopropan-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

(S)-4′

-(5-aminopyrazin-2-yl)-N-(1-cyanopropan-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-(2-cyanoethyl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-methyloxetan-3-yl)biphenyl-2-sulfonamide,

3-(4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-1-yl)propanenitrile,

(S)-4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(1-methoxypropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

5-{3-Fluoro-2′

-[(4-pyrazin-2-ylpiperazin-1-yl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(4-pyrimidin-2-ylpiperazin-1-yl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine,

5-(2′

-Amino-3-fluorobiphenyl-4-yl)pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[1-(hydroxymethyl)cyclopentyl]biphenyl-2-sulfonamide,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-3-phenylpyrrolidin-3-ol,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrrolidine-1-sulfonamide,

N′

-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N,N-dimethylsulfamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]morpholine-4-sulfonamide,

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-3-ol,

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-3-ol,

(3S,4S)-1′

-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-1,3′

-bipyrrolidin-4′

-ol,

(3S,4S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-morpholin-4-ylpyrrolidin-3-ol,

(3S,4S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-(4-methylpiperazin-1-yl)pyrrolidin-3-ol,

5-{3-Fluoro-2′

-[(trifluoromethyl)-sulfanyl]biphenyl-4-yl}pyrazin-2-amine,

5-[2′

-(tert-Butylsulfanyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(Ethylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(propylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-{3-Fluoro-2′

-[(2-methylpropyl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine,

5-[2′

-(tert-Butylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(Cyclopentylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(Cyclobutylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(Cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-{3-Fluoro-2′

-[(1-methylethyl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(trifluoromethyl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}acetamide,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}-N,N-diethylacetamide,

5-{3-Fluoro-2′

-[(2-morpholin-4-yl-2-oxoethyl)sulfanyl]biphenyl-4-yl}pyrazin-2-amine,

(racemic) 5-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}methyl)-1,3-oxazolidin-2-one,

N-(2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}ethyl)benzamide,

5-(3-Fluoro-2′

-{[4-(methylsulfonyl)benzyl]sulfanyl}biphenyl-4-yl)pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide,

5-[3-Fluoro-2′

-(methylsulfonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methyl-4-(trifluoromethyl)biphenyl-2-sulfonamide,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]sulfonyl}piperazin-2-one,

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)-4-(trifluoromethyl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-ethyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide,

5-{3-Fluoro-2′

-[(4-methylpiperazin-1-yl)sulfonyl]-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazin-2-amine,

5-[3-Fluoro-2′

-(pyrimidin-2-ylsulfanyl)biphenyl-4-yl]pyrazin-2-amine hydrochloride,

5-[3-Fluoro-2′

-(pyrimidin-4-ylsulfanyl)biphenyl-4-yl]pyrimidin-2-amine formate salt,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-4-amine hydrochloride,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-4-amine hydrochloride,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-5-amine hydrochloride,

5-[3-Fluoro-2′

-(pyrazin-2-ylsulfanyl)biphenyl-4-yl]pyrazin-2-amine hydrochloride,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-5-amine hydrochloride,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methyl methanesulfonamide formic acid salt,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-(2-hydroxyethyl)methanesulfonamide formic acid salt,

1-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)azetidin-3-ol formic acid salt,

4-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)piperazin-2-one formic acid salt,

(S)-1-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)-N-(1-hydroxypropan-2-yl)methanesulfonamide,

(R)-1-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)-N-(1-hydroxypropan-2-yl)methanesulfonamide hydrochloride,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-(trans-4-hydroxycyclohexyl)methanesulfonamide,

(S)-1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-[(2S)-2-hydroxypropyl]methanesulfonamide hydrochloride,

(R)-1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-[(2S)-2-hydroxypropyl]methanesulfonamide,

5-(2′

-{[(4-Aminopiperidin-1-yl)sulfonyl]methyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine hydrochloride,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methanesulfonamide hydrochloride,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-ethylmethanesulfonamide formate salt,

1-[1-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)piperidin-4-yl]urea hydrochloride,

N-[1-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)piperidin-4-yl]acetamide formate salt,

5-{2′

-[(Ethylsulfanyl)methyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine formate salt,

5-{3-Fluoro-2′

-[(methylsulfanyl)methyl]biphenyl-4-yl}pyrazin-2-amine hydrochloride,

5-(3-Fluoro-2′

-{[(1-methylethyl)sulfanyl]methyl}biphenyl-4-yl)pyrazin-2-amine hydrochloride,

2-(((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)methyl)thio)pyrimidin-4-amine hydrochloride,

6-(((4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)methyl)thio)pyrimidin-4-amine hydrochloride,

5-(3-fluoro-2′

-((pyridazin-3-ylthio)methyl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine hydrochloride,

6-(((4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)methyl)thio)pyridazin-3-amine hydrochloride,

5-{2′

-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-2-amine hydrochloride,

5-(3-fluoro-2′

-((pyrimidin-4-ylthio)methyl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine hydrochloride,

5-[3-Fluoro-2′

-({[2-(trimethylsilyl)ethoxy]methyl}sulfanyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-({[2-(trimethylsilyl)ethoxy]methyl}sulfonyl)biphenyl-4-yl]pyrazin-2-amine hydrochloride,

5-(3-Fluoro-2′

-{[3-(methylsulfonyl)propyl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine hydrochloride,

5-(3-Fluoro-2′

-{[(2R)-2-methylpiperazin-1-yl]sulfonyl}biphenyl-4-yl)pyrimidin-2-amine,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)propyl]biphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-N-(2-cyanoethyl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-N-(2-cyanoethyl)-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(3-hydroxy-2,2-dimethylpropyl)biphenyl-2-sulfonamide,

racemic (4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}morpholin-2-yl)methanol,

5-(3-Fluoro-2′

-{[(2S)-2-methylpiperazin-1-yl]sulfonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-[2′

-(Cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]biphenyl-2-sulfonamide,

4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-N-methyl-N-[(3S)-piperidin-3-yl]biphenyl-2-sulfonamide,

4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-N-methyl-N-[(3R)-piperidin-3-yl]biphenyl-2-sulfonamide,

[(2R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-2-yl]methanol,

racemic cis 4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(cis)-2-hydroxycyclohexyl]biphenyl-2-sulfonamide,

racemis trans 4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(trans)-2-hydroxycyclohexyl]biphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)-N-(1-methylethyl)biphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(trans-4-hydroxycyclohexyl)biphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(3S)-2-oxopyrrolidin-3-yl]biphenyl-2-sulfonamide,

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(2R)-2-hydroxypropyl]biphenyl-2-sulfonamide,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}azetidin-3-ol trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(3R)-2-oxopiperidin-3-yl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(3S)-2-oxopiperidin-3-yl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1R)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1R)-1-(hydroxymethyl)-2,2-dimethylpropyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxy-2-methylpropyl)biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1R)-1-(hydroxymethyl)-2-methylpropyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-N-[(2S)-2,3-dihydroxypropyl]-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide trifluoroacetic acid salt,

[(2R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-2-yl]methanol trifluoroacetic acid salt,

[(2S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-2-yl]methanol trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(2S)-2-hydroxypropyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxy-1,1-dimethylethyl)biphenyl-2-sulfonamide trifluoroacetic acid salt,

5-{2′

-[(4-Cyclopropylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine trifluoroacetic acid salt,

2-(4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-1-yl)ethanol trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-N-(cyclopropylmethyl)-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid,

4′

-(2-Aminopyrimidin-5-yl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-phenylbiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-N-tert-butyl-3′

-fluoro-3-methylbiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

5-[3-Fluoro-2′

-(piperazin-1-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1R)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

5-[2′

-(tert-Butylsulfonyl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-methylpropyl)biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-N-ethyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1,1-dimethylethyl)biphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-sulfonamide trifluoroacetic acid salt,

5-[3-Fluoro-2′

-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N,N-dimethylbiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

5-[3-Fluoro-2′

-(piperidin-1-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

5-[3-Fluoro-2′

-(morpholin-4-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine trifluoroacetic acid salt,

5-[3-Fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine trifluoroacetic acid salt,

4′

-(2-aminopyrimidin-5-yl)-N-(tert-butyl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide trifluoroacetic acid salt,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-2-one trifluoroacetic acid salt,

tert-Butyl N-{[4′

-(2-aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-L-alaninate,

N-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-L-alanine,

N-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]pyrrolidine-1-sulfonamide,

N-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]morpholine-4-sulfonamide,

N′

-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]-N,N-dimethylsulfamide,

5-(2′

-(2-oxa-6-azaspiro[3.3]heptan-6-ylsulfony)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyrimidin-2-amine,

6-((4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)-2-thia-6-azaspiro[3.3]heptane 2,2-dioxide,

1-((4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)azetidine-3-carbonitrile,

1-((4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)-3-(trifluoromethyl)azetidin-3-ol,

5-{2′

-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine hydrochloride,

2-(((4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)methyl)quinazolin-4(3H)-one,

1-(3-((4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)propyl)-1H-benzo[d]imidazol-2(3H)-one,

5-(2′

-{[3-(Cyclohexylsulfonyl)propyl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(1-methyl-1H-benzimidazol-2-yl)sulfonyl]biphenyl-4-yl}pyrimidin-2-amine,

5-(2′

-{[(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrimidin-2-amine,

4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide,

5-[3-fluoro-2′

-(methylsulfonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrimidin-2-amine,

4-{[4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]sulfonyl}piperazin-2-one,

4′

-(2-aminopyrimidin-5-yl)-3′

-fluoro-N-methyl-4-(trifluoromethyl)biphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)-4-(trifluoromethyl)biphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-N-ethyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide,

5-{3-Fluoro-2′

-[(4-methylpiperazin-1-yl)sulfonyl]-4′

-(trifluoromethyl)biphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(5-Aminopyrimidin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine formate salt,

5-{2′

-[(4-Aminopyrimidin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine formate salt,

5-{2′

-[(5-Aminopyrimidin-4-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine formate salt,

5-[3-Fluoro-2′

-(pyrimidin-2-ylsulfanyl)biphenyl-4-yl]pyrimidin-2-amine hydrochloride,

5-[3-Fluoro-2′

-(pyrazin-2-ylsulfanyl)biphenyl-4-yl]pyrimidin-2-amine hydrochloride,

5-{2′

-[(6-Aminopyrimidin-4-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine formate salt,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-2-amine formate salt,

5-{2′

-[(6-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine formate salt,

5-{2′

-[(5-Aminopyrimidin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine hydrochloride,

5-[3-Fluoro-2′

-({[2-(trimethylsilyl)ethoxy]methyl}sulfonyl)biphenyl-4-yl]pyrimidin-2-amine formate salt,

5-{2′

-[(5-Aminopyrimidin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine hydrochloride,

5-[3-Fluoro-2′

-({[2-(trimethylsilyl)ethoxy]methyl}sulfanyl)biphenyl-4-yl]pyrimidin-2-amine,

5-(3-Fluoro-2′

-(methylsulfonyl)-[1,1′

-biphenyl]-4-yl)pyridin-2-amine,

4′

-(6-aminopyridin-3-yl)-N-(tert-butyl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-aminopyridin-3-yl)-N,N-diethyl-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

5-(3-fluoro-2′

-(pyrrolidin-1-ylsulfonyl)-[1,1′

-biphenyl]-4-yl)pyridin-2-amine,

5-(3-fluoro-2′

-(piperidin-1-ylsulfonyl)-[1,1′

-biphenyl]-4-yl)pyridin-2-amine,

4′

-(6-aminopyridin-3-yl)-N-cyclohexyl-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

(S)-4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-(1-hydroxypropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-isobutyl-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-(tert-pentyl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(S)-4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1-phenylethyl)-[1,1′

-biphenyl]-2-sulfonamide,

(R)-4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-(1-hydroxypropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-(1-methylcyclobutyl)-[1,1′

-biphenyl]-2-sulfonamide,

4-((4′

-(6-aminopyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)thiomorpholine 1,1-dioxide,

(S)-4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-(1,1,1-trifluoropropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

5-(2′

-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyridin-2-amine,

tert-butyl 3-((4′

-(6-aminopyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-ylsulfonamido)methyl)-3-hydroxyazetidine-1-carboxylate,

4′

-(6-aminopyridin-3-yl)-3′

-fluoro-N-((3-hydroxyazetidin-3-yl)methyl)-[1,1′

-biphenyl]-2-sulfonamide,

2-(1-((4′

-(6-aminopyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperidin-4-yl)ethanol,

1-((4′

-(6-aminopyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperidin-4-ol,

(1-((4′

-(6-aminopyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperidin-4-yl)methanol,

3′

-Fluoro-N-[(1S)-2-hydroxy-1-methylethyl]-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

3′

-Fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

3′

-Fluoro-N-[(3S)-2-oxopyrrolidin-3-yl]-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

5-[2′

-(Cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]-1H-pyrrolo[2,3-b]pyridine,

3′

-Fluoro-N-(2-hydroxyethyl)-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

3′

-Fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]methanesulfonamide,

3′

-Fluoro-N,N-dimethyl-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide,

2-[3-Fluoro-2′

-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

N,N-Diethyl-3′

-fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide,

2-[3-Fluoro-2′

-(piperidin-1-ylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

2-[3-Fluoro-2′

-(morpholin-4-ylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-N-(2,2,2-trifluoro-1-methylethyl)biphenyl-2-sulfonamide,

2-[3-Fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

3′

-Fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide,

3′

-Fluoro-N-methyl-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide,

3′

-Fluoro-N-[(1S)-2-hydroxy-1-methylethyl]-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide,

1-{[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]sulfonyl}piperidin-4-amine,

2-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}-5H-pyrrolo[2,3-b]pyrazine,

2-[3,5′

-Difluoro-2′

-(methylsulfanyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

2-[2′

-(Ethylsulfanyl)-3-fluorobiphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

7-[3-Fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine,

7-[3-Fluoro-2′

-(piperidin-1-ylsulfonyl)biphenyl-4-yl]-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine,

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

1-{[4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-amine,

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-sulfonamide,

7-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine,

N-tert-Butyl-4′

-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-3′

-fluorobiphenyl-2-sulfonamide,

2-(2-Fluoro-4-{2-[(1-methylethyl)sulfanyl]-5-(trifluoromethyl)pyridin-3-yl}phenyl)-5H-pyrrolo[2,3-b]pyrazine,

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfanyl]pyridin-3-yl}phenyl)pyrazin-2-amine,

2-{2-Fluoro-4-[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]phenyl}-5H-pyrrolo[2,3-b]pyrazine,

2-{2-Fluoro-4-[2-(2-methylpropoxy)pyridin-3-yl]phenyl}-5H-pyrrolo[2,3-b]pyrazine,

2-{2-Fluoro-4-[2-(1-methylethoxy)pyridin-3-yl]phenyl}-5H-pyrrolo[2,3-b]pyrazine,

2-{4-[2-(Cyclopropylmethoxy)pyridin-3-yl]-2-fluorophenyl}-5H-pyrrolo[2,3-b]pyrazine,

5-{2-Fluoro-4-[2-(1-methylethoxy)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{4-[2-(Cyclopentyloxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

5-{4-[2-(Cyclohexyloxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

5-[2-Fluoro-4-(2-methoxypyridin-3-yl)phenyl]pyrazin-2-amine,

5-{4-[2-(Cyclobutyloxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

tert-Butyl 3-[({3-[4-(5-aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)methyl]pyrrolidine-1-carboxylate,

5-{2-Fluoro-4-[2-(pyrrolidin-3-ylmethoxy)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{2-Fluoro-4-[2-(1-methylethoxy)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-[4-(2-Aminopyridin-3-yl)-2-fluorophenyl]pyrimidin-2-amine,

4′

-(5-amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

3-Amino-6-[2′

-(cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carbonitrile,

4′

-(5-Amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

4′

-(5-Amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide,

3-Amino-6-{3-fluoro-2′

-[(3-oxopiperazin-1-yl)sulfonyl]biphenyl-4-yl}pyrazine-2-carbonitrile,

4′

-(5-Amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2R)-2-hydroxypropyl]biphenyl-2-sulfonamide,

3-Amino-6-[3-fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]pyrazine-2-carbonitrile,

4′

-(6-Aminopyridazin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)biphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(1,8-naphthyridin-3-yl)biphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-quinoxalin-6-ylbiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(1H-indol-5-yl)biphenyl-2-sulfonamide,

4′

-(1H-Benzimidazol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(1H-Benzimidazol-5-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide,

4′

-(1,3-Benzothiazol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(1H-pyrrolo[3,2-b]pyridin-6-yl)biphenyl-2-sulfonamide,

3′

-Fluoro-N-methyl-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

4′

-(5-Aminopyridin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-4′

-(5,6-diaminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyrazin-5-yl)biphenyl-2-sulfonamide,

4′

-(6-Amino-5-fluoropyridin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-4′

-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(3H-imidazo[4,5-b]pyridin-6-yl)biphenyl-2-sulfonamide,

4′

-(5-Amino-6-methoxypyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Amino-6-cyanopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(6-Amino-4-cyanopyridin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(6-amino-2-cyanopyridin-3-yl)-N-(tert-butyl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-Amino-6-chloropyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Amino-6-bromopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

6-amino-3-(2′

-(cyclopropylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)picolinonitrile,

N-tert-Butyl-3′

-fluoro-4′

-[1,2,4]triazolo[4,3-a]pyridin-7-ylbiphenyl-2-sulfonamide,

4′

-(5-Amino-6-methylpyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Amino-6-methylpyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(1H-imidazo[4,5-b]pyrazin-5-yl)biphenyl-2-sulfonamide,

N-tert-Butyl-4′

-(5,6-diaminopyridin-3-yl)-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Amino-6-methylpyrazin-2-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide,

4′

-(6-Amino-5-cyanopyridin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(6-Amino-5-chloropyridin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-[2-Amino-4-(trifluoromethyl)pyrimidin-5-yl]-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Amino-4-methylpyrimidin-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

N-tert-Butyl-3′

-fluoro-4′

-[3-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]biphenyl-2-sulfonamide,

4′

-(7-Amino-1H-indol-5-yl)-3′

-fluoro-N-[1-(hydroxymethyl)cyclopentyl]biphenyl-2-sulfonamide,

3′

-Fluoro-4′

-[3-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-methylbiphenyl-2-sulfonamide,

4′

-(7-Amino-1H-indol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]acetamide,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]urea,

5-[2,3-Difluoro-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-2′

,3′

-difluorobiphenyl-2-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-2′

-methylbiphenyl-2-yl]methanesulfonamide,

4′

-(5-Aminopyrazin-2-yl)-2′

,3′

-difluorobiphenyl-2-sulfonamide,

4′

-(2-Aminopyrimidin-5-yl)-2′

,3′

-difluoro-N-methylbiphenyl-2-sulfonamide trifluoroacetic acid salt,

4′

-(2-Aminopyrimidin-5-yl)-N-tert-butyl-2′

,3′

-difluorobiphenyl-2-sulfonamide trifluoroacetic acid salt,

5-[2′

,3-Difluoro-4′

-(trifluoromethoxy)biphenyl-4-yl]pyrazin-2-amine,

5-(2′

,3-Difluorobiphenyl-4-yl)pyrazin-2-amine,

5-(2′

-Chloro-3-fluorobiphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-methylbiphenyl-4-yl)pyrazin-2-amine,

5-[2′

,3-Difluoro-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-(3-Fluoro-2′

-methoxybiphenyl-4-yl)pyrazin-2-amine,

5-[3-Fluoro-2′

-(methylsulfanyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(trifluoromethoxy)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-ol,

5-[3-Fluoro-2′

-(phenylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-(2′

,3,6′

-Trifluorobiphenyl-4-yl)pyrazin-2-amine,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]benzenesulfonamide,

5-(2′

-Ethyl-3-fluorobiphenyl-4-yl)pyrazin-2-amine,

{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetic acid,

5-[3-Fluoro-2′

-(1-methylethyl)biphenyl-4-yl]pyrazin-2-amine,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]ethanone,

5-[3-Fluoro-2′

-(2,2,2-trifluoroethoxy)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-carboxylic acid,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-carboxamide,

5-[3-Fluoro-2′

-(1-methylethoxy)biphenyl-4-yl]pyrazin-2-amine,

5-{4-[2-(Cyclopropylmethoxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

2-[3,4′

-Difluoro-2′

-(methylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methylmethanesulfonamide,

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]ethanesulfonamide,

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]-N-methylmethanesulfonamide,

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]-N-methylethanesulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methylethanesulfonamide,

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]-2-methylpropane-1-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-ethylmethanesulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N,2-dimethylpropane-1-sulfonamide,

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]-1H-pyrrolo[2,3-b]pyridine,

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]pyrimidin-2-amine,

2-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

,4-difluorobiphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-carboxamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[((1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide,

5-[3-Fluoro-2′

-(piperazin-1-ylcarbonyl)biphenyl-4-yl]pyrazin-2-amine,

5-{2′

-[(4-Acetylpiperazin-1-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-cyclohexyl-3′

-fluorobiphenyl-2-carboxamide,

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methylbiphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[((1R)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-carboxamide,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-4-ol,

5-{2′

-[(4-Aminopiperidin-1-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-carboxamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1R)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperazin-2-one,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperazin-2-one,

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrimidin-2-amine,

4-{[3′

-Fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-yl]oxy}pyrimidin-2-amine,

2-{[3′

-Fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-yl]oxy}pyrimidin-4-amine,

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]-1H-pyrrolo[2,3-b]pyridine,

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]pyrimidin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-4-amine,

5-{2′

-[(4-Aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

6-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}methyl)pyridine-2-carbonitrile,

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}methyl)pyridine-3-carbonitrile,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-2-amine,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-2-amine,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-4-amine,

5-{2′

-[(6-Aminopyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile,

5-{2′

-[(6-Azetidin-1-ylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(6-Azetidin-1-ylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(2-methylpyrimidin-4-yl)oxy]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(2-methylpyrimidin-4-yl)oxy]biphenyl-4-yl}pyrimidin-2-amine,

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]-1H-benzimidazole,

6-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]-3H-imidazo[4,5-b]pyridine,

5-{3-Fluoro-2′

-[(4-methylpyrimidin-2-yl)oxy]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(4-methylpyrimidin-2-yl)oxy]biphenyl-4-yl}pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}biphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(5-methoxypyrimidin-2-yl)oxy]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(5-methoxypyrimidin-2-yl)oxy]biphenyl-4-yl}pyrimidin-2-amine,

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrimidin-2-amine,

5-[3-Fluoro-2′

-methoxy-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-ol,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]oxy}pyrimidin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]oxy}pyrimidin-4-amine,

5-[3-Fluoro-4′

-(trifluoromethyl)-2′

-{[2-(trimethylsilyl)ethoxy]methoxy}biphenyl-4-yl]pyrimidin-2-amine,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-ol,

5-{2′

-[(4-Aminopyrimidin-2-yl)oxy]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrimidin-2-amine,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]oxy}pyrimidin-2-amine,

5-{2′

-[(6-Aminopyrimidin-4-yl)oxy]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrimidin-2-amine,

5-[3-Fluoro-2′

,4′

-bis(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carbonitrile,

5-{5-[2-(Pyrimidin-2-yloxy)-4-(trifluoromethyl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

4-{2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-5-(trifluoromethyl) phenoxy}pyrimidin-2-amine,

5-{5-[2-(Pyrimidin-2-yloxy)phenyl]pyridin-2-yl}pyrimidin-2-amine,

4-{2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]phenoxy}pyrimidin-2-amine,

5-(5-{2-[(4-Aminopyrimidin-2-yl)oxy]phenyl}pyridin-2-yl)pyrimidin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-methylbiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-methoxybiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butylbiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N,N-dimethylbiphenyl-2-sulfonamide,

5-[2′

-(Morpholin-4-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-2′

-fluorobiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-2′

-fluoro-N,N-dimethylbiphenyl-2-sulfonamide,

4′

-(2-Amino-1,3-oxazol-4-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(8-fluoroimidazo[1,2-a]pyridin-2-yl)biphenyl-2-sulfonamide,

4′

-(5-Aminoimidazo[1,2-a]pyridin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

2-[2′

-(tert-Butylsulfamoyl)-3-fluorobiphenyl-4-yl]imidazo[1,2-a]pyridine-6-carboxamide,

2-[2′

-(tert-Butylsulfamoyl)-3-fluorobiphenyl-4-yl]imidazo[1,2-a]pyridine-6-carboxamide,

N-tert-Butyl-4′

-(5-cyanoimidazo[1,2-a]pyridin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-4′

-(6-cyanoimidazo[1,2-a]pyridin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]biphenyl-2-sulfonamide,

Ethyl 2-[2′

-(tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl]imidazo[1,2-a]pyridine-5-carboxylate,

N-tert-Butyl-3′

-fluoro-4′

-(5-methoxyimidazo[1,2-a]pyridin-2-yl)biphenyl-2-sulfonamide,

5-[2′

-(Methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Methyl-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N,N,3′

-trimethylbiphenyl-2-sulfonamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-hydroxybiphenyl-2-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)biphenyl-2-yl]methanesulfonamide,

4′

-(5-Aminopyrazin-2-yl)biphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(2-oxo-2,3-dihydro-1H-indol-5-yl)biphenyl-2-sulfonamide,

N-tert-Butyl-4′

-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3′

-fluorobiphenyl-2-sulfonamide,

4′

-(3-Amino-1H-indazol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

3-Amino-6-[2′

-(tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carboxylic acid,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}acetamide,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-N,N-diethylacetamide,

5-{3-Fluoro-2′

-[(2-morpholin-4-yl-2-oxoethyl)sulfonyl]biphenyl-4-yl}pyrimidin-2-amine,

5,5′

-(3,3″

-Difluoro-1,1′

;

2′

,1″

-terphenyl-4,4″

-diyl)dipyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carboxylic acid,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carbaldehyde,

5-[3-Fluoro-2′

-(morpholin-4-ylmethyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-{2′

-[(4-Aminopiperidin-1-yl)methyl]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazin-2-amine,

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol,

5-{2′

-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyridin-4-yl]oxy}biphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyridin-4-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}biphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-5-amine,

5-{2′

-[(5-Aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}-6-methylpyrimidin-4-amine,

5-{2′

-[(4-Amino-6-methyl pyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

6-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile,

5-{2′

-[(5-Aminopyridin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(5-Aminopyridin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(6-Amino-2-methylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}-2-methylpyrimidin-4-amine,

5-(3-Fluoro-2′

-{[6-(trifluoromethyl)pyridin-2-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[6-(trifluoromethyl)pyridin-2-yl]oxy}biphenyl-4-yl)pyrazin-2-amine,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile,

6-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}ethanol,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}ethanol,

5-[3-Fluoro-2′

-(piperidin-4-yloxy)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(piperidin-4-yloxy)biphenyl-4-yl]pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(3R)-piperidin-3-yloxy]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(3R)-piperidin-3-yloxy]biphenyl-4-yl}pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(3S)-piperidin-3-yloxy]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(3S)-piperidin-3-yloxy]biphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(6-Cyclopropylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(6-Cyclopropylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(2-Aminopyridin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(2-Aminopyridin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-[2′

-(2-Aminoethoxy)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(2-Aminoethoxy)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine,

{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetonitrile,

{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetonitrile,

{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetic acid,

5-{2-Fluoro-4-[2-(piperidin-4-yloxy)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{2-Fluoro-4-[2-(piperidin-4-yloxy)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

2-({3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)ethanol,

2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)ethanol,

5-(4-{2-[(trans-4-Aminocyclohexyl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

5-(4-{2-[(trans-4-Aminocyclohexyl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine formic acid salt,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]phenyl}pyrimidin-2-amine,

(2R)-2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol,

(2R)-2-({3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol,

(2S)-2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol,

(2I)-2-({3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol,

N-(4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)methanesulfonamide,

5-(3-Fluoro-2′

-(morpholinosulfonyl)-[1,1′

-biphenyl]-4-yl)pyridin-2-amine,

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-methyl-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide trifluoroacetate,

5-(2′

-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyridin-2-amine,

4′

-(6-Aminopyrazin-2-yl)-3′

-fluoro-N-((3-hydroxyazetidin-3-yl)methyl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(1-hydroxy-2-methylpropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-N-(1-hydroxy-2-methylpropan-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

(racemic)-1-((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-[1, 1′

-biphenyl]-2-yl)sulfonyl)piperidin-3-ol,

4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-[1,1′

-biphenyl]-2-sulfonamide,

N-(1-((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperidin-4-yl)acetamide,

racemic 2-(1-((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperidin-3-yl)ethanol,

racemic 1-((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperidin-3-yl)methanol,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(2R)-2-hydroxypropyl]benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-ethyl-5-(trifluoromethyl)benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-tert-butylbenzenesulfonamide,

5-{5-[2-(Morpholin-4-ylmethyl)-4-(trifluoromethyl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

5-{5-[2-(Morpholin-4-ylcarbonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

5-[5-(2-Methoxyphenyl)pyridin-2-yl]pyrimidin-2-amine,

5-(5-{2-[(3,3-Difluoropiperidin-1-yl)sulfonyl]phenyl}pyridin-2-yl)pyrimidin-2-amine trifluoroacetic acid salt,

5-(5-{2-[(3,3-Difluoropyrrolidin-1-yl)sulfonyl]phenyl}pyridin-2-yl)pyrimidin-2-amine trifluoroacetic acid salt,

5-{5-[2-(Azepan-1-ylsulfonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine trifluoroacetic acid salt,

5-(5-{2-[(4,4-Difluoropiperidin-1-yl)sulfonyl]phenyl}pyridin-2-yl)pyrimidin-2-amine trifluoroacetic acid salt,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-ethylbenzenesulfonamide trifluoroacetic acid salt,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-(dicyclopropylmethyl)benzenesulfonamide trifluoroacetic acid salt,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide trifluoroacetic acid salt,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1R)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide trifluoroacetic acid salt,

4-({2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]phenyl}sulfonyl)piperazin-2-one,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(2S)-2-hydroxypropyl]benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(2R)-2-hydroxypropyl]benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-(2-hydroxyethyl)-5-(trifluoromethyl)benzenesulfonamide,

5-{5-[2-(Cyclopropylsulfonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine trifluoroacetic acid salt,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-ethyl-5-(trifluoromethyl)benzenesulfonamide trifluoroacetic acid salt,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-tert-butylbenzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]benzenesulfonamide,

3-Amino-6-{2′

-[(4-aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile trifluoroacetic acid salt,

5-(4′

-Bromo-2′

,3-difluorobiphenyl-4-yl)pyrazin-2-amine,

5-(4′

-Bromo-2′

,3-difluorobiphenyl-4-yl)-1H-pyrrolo[2,3-b]pyridine,

5-(3-fluoro-2-methoxy-4′

-(trifluoromethyl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

5-(2′

,3,4′

-Trifluorobiphenyl-4-yl)pyrazin-2-amine,

racemic 5-[3-Fluoro-2′

-(methylsulfinyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-carbonitrile,

1-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1, 1′

-biphenyl]-2-yl)imidazolidin-2-one,

4′

-(2-Amino-4-cyanopyrimidin-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

6-Amino-3-{2′

-[(1,1-dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-N-methylazetidine-3-carboxamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2S)-2-hydroxypropyl]biphenyl-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2R)-2-hydroxypropyl]biphenyl-2-sulfonamide,

1-((4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperidine-4-carboxamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)-4-(trifluoromethyl)biphenyl-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-N-ethyl-3′

-fluoro-4-(trifluoromethyl)-[1,1′

-biphenyl]-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxy-2,2-dimethylpropyl)biphenyl-2-sulfonamide,

6-Amino-3-{3-fluoro-2′

-[(3-oxopiperazin-1-yl)sulfonyl]-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazine-2-carbonitrile,

N-(2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}ethyl)benzamide,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-3,3-dimethylbutan-2-one,

5-[3-Fluoro-2′

-(pyrimidin-2-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine,

5-[3-Fluoro-2′

-(pyrazin-2-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine,

5-[3-Fluoro-2′

-(pyrimidin-4-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine,

5-{2′

-[(6-Aminopyrimidin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(4-Aminopyrimidin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(5-Aminopyrazin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-2-amine,

5-{2′

-[(6-Aminopyrazin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-4-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-4-amine,

5-{2′

-[(Cyclopropylmethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

6-Amino-3-[2′

-(cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carbonitrile,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarbonitrile,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarboxamide,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanenitrile,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanamide,

5-{2′

-[(2-Amino-1,1-dimethylethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanenitrile,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanamide,

5-{2′

-[(2-Amino-1,1-dimethylethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarbonitrile,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarboxamide,

5-(2′

-{[1-(Aminomethyl)cyclopentyl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrimidin-2-amine,

5-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrazin-2-amine,

5-{2′

-[(6-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-(3-Fluoro-2′

-(pyrimidin-4-ylthio)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

5-{2′

-[(5-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine

6-Amino-3-{2′

-[(4-aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile,

6-Amino-3-[3-fluoro-2′

-(pyrimidin-2-yloxy)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazine-2-carbonitrile,

6-Amino-3-[3-fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]pyrazine-2-carbonitrile,

N-(ter-Butyl)-3′

-fluoro-4′

-(5-(methylsulfonamido)pyrazin-2-yl)-[1,1′

-biphenyl]-2-sulfonamide,

5-{2′

-[(Ethylsulfonyl)methyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine hydrogen chloride salt,

5-{3-Fluoro-2′

-[(methylsulfonyl)methyl]biphenyl-4-yl}pyrazin-2-amine,

5-(3-Fluoro-2′

-{[(1-methylethyl)sulfonyl]methyl}biphenyl-4-yl)pyrazin-2-amine,

5-{3-Fluoro-2′

-[(pyrimidin-2-ylsulfonyl)methyl]biphenyl-4-yl}pyrazin-2-amine,

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfanyl)pyrimidin-4-amine,

racemic 5-(3-Fluoro-2′

-{[2-(trifluoromethyl)morpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}azetidin-3-ol,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(tetrahydro-2H-pyran-4-yl)biphenyl-2-carboxamide,

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)carbonyl]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazin-2-amine,

1-(4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}morpholin-2-yl)ethanol (diastereomeric mixture),

1-(4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}morpholin-2-yl)ethanol (diastereomeric mixture),

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-carboxamide,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-carboxamide,

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

(cis/trans) 4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl)biphenyl-2-carboxamide,

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

(cis/trans) 4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl)biphenyl-2-carboxamide,

racemic 5-(3-Fluoro-2′

-{[2-(trifluoromethyl)morpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol,

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol,

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol,

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrolidin-3-ol,

5-{2′

-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine (diastereoisomeric mixture),

5-(3-Fluoro-2′

-{[(3S)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[(3R)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[(2S)-2-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[(2S)-2-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[(3S)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[(3R)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-{2′

-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine (diastereoisomeric mixture),

5-{2-Fluoro-4-[2-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}-1H-pyrrolo[2,3-b]pyridine,

5-{2-Fluoro-4-[2-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-N-tert-butyl-5-(trifluoromethyl)benzamide,

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-N-[(1R)-2-hydroxy-1-methyl-ethyl]-5-(trifluoromethyl)benzamide,

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-N-[(1S)-2-hydroxy-1-methyl-ethyl]-5-(trifluoromethyl)benzamide,

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1R)-2,2,2-trifluoro-1-methyl-ethyl]benzamide,

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]benzamide,

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1R)-2,2,2-trifluoro-1-methyl-ethyl]benzamide,

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]benzamide,

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]phenyl]-(3-hydroxyazetidin-1-yl)methanone,

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]phenyl]-[4-(methylamino)-1-piperidyl]methanone,

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)phenyl]-(1,1-dioxo-1,4-thiazinan-4-yl)methanone,

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-N-tert-butyl-5-(trifluoromethyl)benzamide,

[2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)phenyl]-(4-hydroxy-1-piperidyl)methanone,

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)phenyl]-(4-hydroxy-1-piperidyl)methanone,

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-N-tetrahydropyran-4-yl-benzamide,

[2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]phenyl]-[2-(hydroxymethyl)morpholin-4-yl]methanone,

racemic [2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]phenyl]-[2-(hydroxymethyl)morpholin-4-yl]methanone,

N-{3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}-2,2-dimethylpropanamide,

N-{3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}-2,2-dimethylpropanamide,

N-{3-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]pyridin-2-yl}-2,2-dimethylpropanamide,

racemic 5-(2-Fluoro-4-(2-(pyrrolidin-3-ylsulfonyl)pyridin-3-yl)phenyl)pyrazin-2-amine hydrochloride,

5-(2-Fluoro-4-(2-(pyrrolidin-3-ylsulfonyl)pyridin-3-yl)phenyl)pyrimidin-2-amine formic acid salt,

5-(4-(2-(Cyclobutylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine hydrochloride,

5-(4-(2-(Cyclobutylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine hydrochloride,

5-(4-(2-(Cyclohexylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine hydrochloride,

5-(4-(2-(Cyclohexylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine hydrochloride,

5-(4-(2-(Cyclopentylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidine-2-amine hydrochloride,

5-(4-(2-(Cyclopentylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine hydrochloride,

5-(4-(2-(tert-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine formic acid salt,

5-(4-(2-(tert-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine formic acid salt,

racemic 5-(4-(2-(sec-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine formate,

racemic 5-(4-(2-(sec-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine formate,

1-((3-(4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)piperidin-1-yl)ethanone,

1-((3-(4-(2-Aminopyrazin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)piperidin-1-yl)ethanone hydrogen chloride salt,

5-(2-Fluoro-4-(2-((3-methoxypropyl)sulfonyl)pyridine-3-yl)phenyl)pyrimidin-2-amine hydrogen chloride salt,

5-(2-Fluoro-4-(2-((3-methoxypropyl)sulfonyl)pyridine-3-yl)phenyl)pyrazin-2-amine hydrogen chloride salt,

4-((3-(4-(2-aminopyrimidin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)tetrahydro-2H-thiopyran 1,1-dioxide,

4-((3-(4-(2-Aminopyrazin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)tetrahydro-2H-thiopyran 1,1-dioxide,

5-(2-Fluoro-4-(2-((2-morpholinoethyl)sulfonyl)pyridine-3-yl)phenyl)pyrimidin-2-amine formic acid salt,

5-(2-Fluoro-4-(2-((2-morpholinoethyl)sulfonyl)pyridine-3-yl)phenyl)pyrazin-2-amine,

5-(2-Fluoro-4-(2-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)pyridine-3-yl)pyrimidin-2-amine formic acid salt,

5-(2-Fluoro-4-(2-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)pyridine-3-yl)pyrazin-2-amine formic acid salt,

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfonyl]pyridin-3-yl}phenyl)pyrimidin-2-amine,

5-(2-Fluoro-4-(2-(isopropylsulfonyl)pyridine-3-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine,

5-{2-Fluoro-4-[2-(piperidin-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine formic acid salt,

5-{4-[2-(Cyclopropylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrimidin-2-amine formic acid salt,

5-{4-[2-(Cyclopropylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine formic acid salt,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-aminehydrochloride

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine formic acid salt,

5-{2-Fluoro-4-[2-(piperidin-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-aminehydrochloride,

5-(2,3-Difluorobiphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2-methoxybiphenyl-4-yl)pyrazin-2-amine,

5-[3-Fluoro-2-methoxy-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-2′

-methoxybiphenyl-2-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-2′

-methoxybiphenyl-2-yl]methanesulfonamide,

5-(3-Fluoro-2′

-(pyrazin-2-yl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-pyrazin-2-ylbiphenyl-4-yl)pyrimidin-2-amine,

5,5′

-(3′

-Fluorobiphenyl-2,4′

-diyl)dipyrazin-2-amine,

5-[2′

-(5-Aminopyrazin-2-yl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine,

5-[2′

-(6-Aminopyrazin-2-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrimidin-2-amine,

5,5′

-(3′

-Fluorobiphenyl-2,4′

-diyl)dipyrimidin-2-amine,

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-5-(trifluoromethyl)biphenyl-2-yl]pyrimidin-2-amine,

5-[3-Fluoro-2′

-(2-methoxypyrimidin-5-yl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Fluoro-2′

-(1-methyl-1H-pyrazol-4-yl)biphenyl-4-yl]pyrazin-2-amine,

5-(3-Fluoro-2′

-pyrimidin-5-ylbiphenyl-4-yl)pyrazin-2-amine,

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrimidine-2-carbonitrile,

5-[3-Fluoro-2′

-(2-morpholin-4-ylpyrimidin-5-yl)biphenyl-4-yl]pyrazin-2-amine,

1-{4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol,

5-[3-Fluoro-2′

-(1,2,3,6-tetrahydropyridin-4-yl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]pyrimidin-2-amine,

5-{2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]phenyl}pyrimidin-2-amine,

5-{5-[2-(2-Aminopyrimidin-5-yl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

5-[2′

-(1,1-Dioxidoisothiazolidin-2-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(1,1-Dioxido-1,2-thiazinan-2-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(1,1-Dioxidoisothiazolidin-2-yl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine,

5-[2-Fluoro-4-(2-pyrrolidin-1-ylpyridin-3-yl)phenyl]pyrazin-2-amine,

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrrolidin-2-one,

5-(4′

-Bromo-2′

,3-difluorobiphenyl-4-yl)-1H-pyrrolo[2,3-b]pyridine,

5-(2′

,3,4′

-Trifluorobiphenyl-4-yl)pyrazin-2-amine,

5-[3-Fluoro-2′

-(methylsulfinyl)biphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(Methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

5-[3-Methyl-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-hydroxybiphenyl-2-sulfonamide,

N-[4′

-(5-Aminopyrazin-2-yl)biphenyl-2-yl]methanesulfonamide,

4′

-(5-Aminopyrazin-2-yl)biphenyl-2-sulfonamide,

4′

-(6-Aminopyridazin-3-yl)-3′

-fluorobiphenyl-2-sulfonamide,

N-tert-Butyl-4′

-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3′

-fluorobiphenyl-2-sulfonamide,

3-Amino-6-[2′

-(tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carboxylicacid,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-5-(trifluoromethyl)biphenyl-2-sulfonamide,

5-{5-[2-(Cyclopropylsulfonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}acetamide,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-N,N-diethylacetamide,

5-{3-Fluoro-2′

-[(2-morpholin-4-yl-2-oxoethyl)sulfonyl]biphenyl-4-yl}pyrimidin-2-amine,

5-[5-(2-Methoxyphenyl)pyridin-2-yl]pyrimidin-2-amine,

5-{5-[2-(Morpholin-4-ylcarbonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

4′

-(2-Amino-4-cyanopyrimidin-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

5-[3-Fluoro-2′

-(pyrimidin-2-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine,

5-[3-Fluoro-2′

-(pyrazin-2-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine,

N-(2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}ethyl)benzamide,

5-[3-Fluoro-2′

-(pyrimidin-4-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine,

5-{2′

-[(6-Aminopyrimidin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(4-Aminopyrimidin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(5-Aminopyrazin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-(2-Fluoro-4-{2-[(2-morpholin-4-ylethyl)sulfonyl]pyridin-3-yl}phenyl)pyrimidin-2-amine,

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-5-(trifluoromethyl)biphenyl-2-yl]pyrimidin-2-amine,

5-{5-[2-(2-Aminopyrimidin-5-yl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{2-Fluoro-4-[2-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[(3S)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(piperidin-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine,

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol,

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol,

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol,

2-({3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)ethanol,

5-{2′

-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

5-[3-Fluoro-2′

-(piperidin-4-yloxy)biphenyl-4-yl]pyrimidin-2-amine,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanamide,

5-{3-Fluoro-2′

-[(3R)-piperidin-3-yloxy]biphenyl-4-yl}pyrimidin-2-amine,

5-(2′

-{[1-(Aminomethyl)cyclopentyl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrimidin-2-amine,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl)biphenyl-2-carboxamide,

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetic acid,

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(tetrahydro-2H-pyran-4-yl)biphenyl-2-carboxamide,

5-[2′

-(2-Aminoethoxy)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(2-Aminoethoxy)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine,

2-[3,5′

-Difluoro-2′

-(methylsulfanyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

N-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]methanesulfonamide,

4′

-(5-Aminopyrazin-2-yl)-N,N,3′

-trimethylbiphenyl-2-sulfonamide,

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide,

N-tert-Butyl-3′

-fluoro-4′

-(2-oxo-2,3-dihydro-1H-indol-5-yl)biphenyl-2-sulfonamide,

4′

-(3-Amino-1H-indazol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide,

5-(3-Fluoro-2′

-{[(3R)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)morpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-[3-Fluoro-2′

-(piperidin-4-yloxy)biphenyl-4-yl]pyrazin-2-amine,

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-2′

-methoxybiphenyl-2-yl]methanesulfonamide,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}azetidin-3-ol,

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-carbonitrile,

(2R)-2-({3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol,

5-{2-Fluoro-4-[2-(piperidin-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{2′

-[(6-Aminopyrazin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

4′

-(6-Aminopyridin-3-yl)-3′

-fluorobiphenyl-2-sulfonamide,

5-{3-Fluoro-2′

-[(methylsulfonyl)methyl]biphenyl-4-yl}pyrazin-2-amine,

5-{3-Fluoro-2′

-[(3S)-piperidin-3-yloxy]biphenyl-4-yl}pyrimidin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl)biphenyl-2-carboxamide,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-3,3-dimethylbutan-2-one,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-4-amine,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}ethanol,

2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)ethanol,

5-{2′

-[(Cyclopropylmethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

N-[4′

-(6-Aminopyridin-3-yl)-3′

-fluorobiphenyl-2-yl]methanesulfonamide,

4-({2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]phenyl}sulfonyl)piperazin-2-one,

5-{2-Fluoro-4-[2-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}-1H-pyrrolo[2,3-b]pyridine,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(2S)-2-hydroxypropyl]benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]benzenesulfonamide,

5-{2-Fluoro-4-[2-(pyrrolidin-3-ylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-(5-{2-[(3,3-Difluoropyrrolidin-1-yl)sulfonyl]phenyl}pyridin-2-yl)pyrimidin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-ethylbenzenesulfonamide,

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

(2S)-2-({3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol,

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanenitrile,

(2R)-2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(2R)-2-hydroxypropyl]benzenesulfonamide,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-4-amine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-5-methoxybiphenyl-2-sulfonamide,

5-(2-Fluoro-4-{2-[(3-methoxypropyl)sulfonyl]pyridin-3-yl}phenyl)pyrimidin-2-amine,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarboxamide,

5-[3-Fluoro-2-methoxy-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}ethanol,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1R)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanamide,

{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetonitrile,

5-{4-[2-(tert-Butylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(3S)-piperidin-3-yloxy]biphenyl-4-yl}pyrazin-2-amine,

5-(4-{2-[(trans-4-Aminocyclohexyl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

5-(2-Fluoro-4-{2-[(2-morpholin-4-ylethyl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfonyl]pyridin-3-yl}phenyl)pyrimidin-2-amine,

5-(4-{2-[(1-Acetylpiperidin-4-yl)sulfonyl]pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

5-(4′

-Bromo-2′

,3-difluorobiphenyl-4-yl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyridin-4-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine,

5-{2′

-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2′

-[(Ethylsulfonyl)methyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarbonitrile,

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3-carboxamide,

5-{5-[2-(Morpholin-4-ylmethyl)-4-(trifluoromethyl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

5-(5-{2-[(4,4-Difluoropiperidin-1-yl)sulfonyl]phenyl}pyridin-2-yl)pyrimidin-2-amine,

5-{2′

-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-(3-Fluoro-2′

-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine,

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3-carboxamide,

5-(2-Fluoro-4-{2-[(tetrahydro-2H-pyran-4-ylmethyl)sulfonyl]pyridin-3-yl}phenyl)pyrimidin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-(2-hydroxyethyl)-5-(trifluoromethyl)benzenesulfonamide,

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol,

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]pyrazin-2-amine,

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol,

5-{3-Fluoro-2′

-[(pyrimidin-2-ylsulfonyl)methyl]biphenyl-4-yl}pyrazin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(2R)-2-hydroxypropyl]benzenesulfonamide,

5-(5-{2-[(3,3-Difluoropiperidin-1-yl)sulfonyl]phenyl}pyridin-2-yl)pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-[3-Fluoro-2′

-(1,2,3,6-tetrahydropyridin-4-yl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-{4-[2-(Cyclopropylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(pyrrolidin-3-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

6-Amino-3-{2′

-[(1,1-dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile,

N-(1-{[4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)acetamide,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-N-methylazetidine-3-carboxamide,

5-[3-Fluoro-2′

-(morpholin-4-ylsulfonyl)biphenyl-4-yl]pyridin-2-amine,

5-(3-Fluoro-2′

-{[(1-methylethyl)sulfonyl]methyl}biphenyl-4-yl)pyrazin-2-amine,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide,

{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetonitrile,

(2S)-2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}propan-1-ol,

6-Amino-3-[2′

-(cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carbonitrile,

5-(4-{2-[(trans-4-Aminocyclohexyl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-ethyl-5-(trifluoromethyl)benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide,

5-{5-[2-(Azepan-1-ylsulfonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-tert-butylbenzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-(dicyclopropylmethyl)benzenesulfonamide,

5-{2′

-[(4-Aminopiperidin-1-yl)methyl]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(6-Amino-2-methyl pyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

6-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylpropyl)sulfonyl]pyridin-3-yl}phenyl)pyrimidin-2-amine,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2S)-2-hydroxypropyl]biphenyl-2-sulfonamide,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanenitrile,

5-{4-[2-(Cyclobutylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrimidin-2-amine,

5-{2′

-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(Cyclopropylmethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carboxylic acid,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyridin-4-yl]oxy}biphenyl-4-yl)pyrazin-2-amine,

5-(2-Fluoro-4-{2-[(3-methoxypropyl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine,

6-Amino-3-[3-fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]pyrazine-2-carbonitrile,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-2′

-methoxybiphenyl-2-sulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2R)-2-hydroxypropyl]biphenyl-2-sulfonamide,

1-{[4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-ol,

5-(4-{2-[(1-Acetylpiperidin-4-yl)sulfonyl]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

5-{2′

-[(6-Cyclopropylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]phenyl}pyrazin-2-amine,

2-(1-{[4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)ethanol,

5-{2′

-[(5-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarboxamide,

6-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile,

5-(3-Fluoro-2′

-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}biphenyl-4-yl)pyrazin-2-amine,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide,

(1-{[4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)methanol,

6-Amino-3-{2′

-[(4-aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile,

5-[3-Fluoro-2′

-(2-methoxypyrimidin-5-yl)biphenyl-4-yl]pyrazin-2-amine

5-(2-Fluoro-4-{2-[(tetrahydro-2H-pyran-4-ylmethyl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine,

5-{4-[2-(tert-Butylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine

3-Amino-6-{2′

-[(4-aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile,

6-Amino-3-{3-fluoro-2′

-[(3-oxopiperazin-1-yl)sulfonyl]-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazine-2-carbonitrile,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carboxamide,

5-(3-Fluoro-2′

-{[6-(trifluoromethyl)pyridin-2-yl]oxy}biphenyl-4-yl)pyrazin-2-amine,

5-{2′

-[(2-Aminopyridin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarbonitrile,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile,

4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-N-(2-hydroxy-1,1-dimethylethyl)biphenyl-2-sulfonamide,

5-{4-[2-(Cyclohexylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(l S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylsulfonyl]biphenyl-4-yl}pyrazin-2-amine,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidine-4-carboxamide,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carbaldehyde,

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(3-hydroxyazetidin-3-yl)methyl]biphenyl-2-sulfonamide,

5-{2′

-[(5-Aminopyridin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrazin-2-amine,

5-{2′

-[(6-Cyclopropylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfanyl)pyrimidin-4-amine,

4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylbiphenyl-2-sulfonamide,

5-{4-[2-(Cyclopentylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrimidin-2-amine,

2-[3-Fluoro-2′

-(methylsulfanyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine,

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

5-{4-[2-(Cyclopropylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylbiphenyl-2-sulfonamide,

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)carbonyl]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazin-2-amine,

N,N-Diethyl-3′

-fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{2′

-[(6-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylpropyl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine,

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(2-hydroxy-1,1-dimethylethyl)biphenyl-2-sulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-ethyl-5-(trifluoromethyl)benzenesulfonamide,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxy-2,2-dimethylpropyl)biphenyl-2-sulfonamide,

6-Amino-3-[3-fluoro-2′

-(pyrimidin-2-yloxy)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazine-2-carbonitrile,

5-[3-Fluoro-2′

-(morpholin-4-ylmethyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)-4

5-{2′

-[(5-Aminopyridin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{4-[2-(Cyclobutylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

4′

-(5-Amino-3-cyanopyrazin-2-yl)-N-ethyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide,

5-[3-Fluoro-2′

-(pyrimidin-4-ylsulfanyl)biphenyl-4-yl]pyrazin-2-amine,

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-(pentafluoroethyl)piperidin-4-ol,

5-{2′

-[(2-Aminopyridin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfonyl]pyridin-3-yl}phenyl)-1H-pyrrolo[2,3-b]pyridine,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-tert-butylbenzenesulfonamide,

tert-Butyl (1-{[3′

-fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]sulfonyl}piperidin-4-yl)carbamate,

5-{4-[2-(Cyclopentylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3,3′

-difluorobiphenyl-2-sulfonamide,

5-{4-[2-(Cyclohexylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

,4-difluorobiphenyl-2-sulfonamide,

5-(3-Fluoro-2′

-{[(2S)-2-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[(2S)-2-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-5-amine,

5-{2′

-[(5-Aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-(2-fluoro-4-(2-(piperidin-4-yloxy)pyridin-3-yl)phenyl)pyrazin-2-amine,

5-{2-Fluoro-4-[2-(piperidin-4-yloxy)pyridin-3-yl]phenyl}pyrimidin-2-amine,

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}-6-methylpyrimidin-4-amine,

5-{2′

-[(4-Amino-6-methylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[(3R)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

5-(3-Fluoro-2′

-{[(3S)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

5-(3-Fluoro-2′

-{[6-(trifluoromethyl)pyridin-2-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine,

5-{3-Fluoro-2′

-[(3R)-piperidin-3-yloxy]biphenyl-4-yl}pyrazin-2-amine,

1-(4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}morpholin-2-yl)ethanol,

1-(4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}morpholin-2-yl)ethanol,

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)morpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine,

N-{3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}-2,2-dimethylpropanamide,

N-{3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}-2,2-dimethylpropanamide,

5-{2′

-[(2-Amino-1,1-dimethylethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(2-Amino-1,1-dimethylethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine,

N-{3-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]pyridin-2-yl}-2,2-dimethylpropanamide,

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide,

5-[2′

-Amino-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine,

5-{2′

-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2′

-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

4-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}methyl)benzoic acid,

4-({[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}methyl)benzoic acid,

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}benzoic acid,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}benzoic acid,

2-[4-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}sulfonyl)piperidin-1-yl]ethanol,

4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrimidin-2-amine,

1-[4-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}sulfonyl)piperidin-1-yl]propan-2-ol,

5-[3-Fluoro-2′

-(1H-pyrazol-4-yl)biphenyl-4-yl]pyrazin-2-amine,

5-[2′

-(6-Aminopyridin-3-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine,

5-{3-Fluoro-2′

-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]biphenyl-4-yl}pyrazin-2-amine,

5-{5-[2-(Cyclopropylsulfonyl)phenyl]-3-fluoropyridin-2-yl}pyrimidin-2-amine,

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}benzamide,

5-{2′

-[(trans-4-Aminocyclohexyl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

5-{2-Fluoro-4-[2-(phenylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

6-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyridazin-3-amine,

{4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1H-pyrazol-1-yl}acetonitrile,

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methylpyrimidin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide,

5-{2-Fluoro-4-[2-(phenylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine,

5-[3-Fluoro-2′

-(2-piperazin-1-ylpyrimidin-5-yl)biphenyl-4-yl]pyrazin-2-amine,

5-{2′

-[1-(2-Aminoethyl)-1H-pyrazol-4-yl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(2S)-2-hydroxypropyl]benzenesulfonamide,

5-(3-Fluoro-2′

-isothiazol-4-ylbiphenyl-4-yl)pyrazin-2-amine,

5-[2-Fluoro-4-(2-phenoxypyridin-3-yl)phenyl]pyrazin-2-amine,

5-[2-Fluoro-4-(2-phenoxypyridin-3-yl)phenyl]pyrimidin-2-amine,

2-{4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1H-pyrazol-1-yl}ethanol,

5-(4-{2-[(1-Acetylpiperidin-3-yl)sulfonyl]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

5-(4-{2-[(1-Acetylpiperidin-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1S)-2-hydroxy-1-methylethyl]benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]benzenesulfonamide,

5-[2-Fluoro-4-(2-phenylpyridin-3-yl)phenyl]pyrazin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylpyrrolidin-3-yl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine,

5-{2-Fluoro-4-[2-(pyridin-3-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfonyl]-6-(trifluoromethyl)pyridin-3-yl}phenyl)pyrazin-2-amine,

5-(4-{2-[(1-Acetylpiperidin-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

5-[2′

-(6-Aminopyridin-3-yl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine,

5-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]-N-methylpyrimidin-2-amine,

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfonyl]-6-(trifluoromethyl)pyridin-3-yl}phenyl)pyrimidin-2-amine,

{4-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]-1H-pyrazol-1-yl}acetonitrile

5-[3-Fluoro-2′

-(1H-pyrazol-4-yl)biphenyl-4-yl]pyrimidin-2-amine,

4-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]pyrimidin-2-amine,

5-{2-Fluoro-4-[2-(pyridin-3-yloxy)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-yl}-2-fluorophenyl)pyrimidin-2-amine,

5-[2-Fluoro-4-(2-{[1-(methylsulfonyl)piperidin-4-yl]sulfonyl}pyridin-3-yl)phenyl]pyrazin-2-amine,

5-(4-{2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}pyrazin-2-amine,

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}pyrimidin-2-amine,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-(2-hydroxyethyl)benzenesulfonamide,

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1R)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide, and

5-[2-Fluoro-4-(2-{[1-(methylsulfonyl)piperidin-4-yl]sulfonyl}pyridin-3-yl)phenyl]pyrimidin-2-amine.

5. A pharmaceutical composition comprising at least one compound of claim 1 and at least one pharmaceutically acceptable carrier.

6. The pharmaceutical composition of claim 5 comprising at least one compound of claim 4.

8. The pharmaceutical composition of claim 5 comprising at least one compound of claim 7.

9. A method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition medicated by FLAP activity, comprising administering to the subject a therapeutically effective amount of at least one compound of claim 1.

10. The method according to claim 9, wherein the disease, disorder, or medical condition is selected from the group consisting of respiratory disorders, cardiac and cardiovascular diseases, autoimmune and allergic disorders, and carcinogenesis disorders.

11. The method according to claim 10, wherein respiratory disorder is selected from the group consisting of non-allergic asthma, fibrotic lung diseases, acute respiratory distress syndrome and chronic obstructive pulmonary disease.

12. The method according to claim 10, wherein the cardiac and cardiovascular disease is selected from the group consisting of myocardial infarction, atherosclerosis and stroke aortic aneurisms, and atherosclerosis.

13. The method according to claim 10, wherein the autoimmune and allergic disease is selected from the group consisting of rheumatoid arthritis, inflammatory bowel disease, nephritis, spondyloarthritis, polymyositis, dermatomyositis, gouty effusions, systemic lupus erythematosus, systemic sclerosis, Alzheimer'"'"'s disease, multiple sclerosis, allergic rhinitis, allergic dermatitis and asthma.

14. The method according to claim 10, wherein the carcinogenesis disorder is selected from the group consisting of tumor cell proliferation, tumor cell differentiation, apoptosis, tumor-associated angiogenesis, and the migration or invasion of carcinoma cells.

15. The method of claim 9, wherein the therapeutically effective amount of the compound of Formula (I) is from about 0.1 mg/dose to about 5 g/dose.

16. A process for making a pharmaceutical composition comprising admixing any of the compounds according to claim 1 and a pharmaceutically acceptable carrier.

7. A compound selected from the group consisting of:

5-(3-Fluoro-2′

-(methylsulfonyl)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methanesulfonamide;

6-Amino-3 -[3-fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazine-2-carbonitrile;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-cyclohexyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-methylbiphenyl-2-sulfonamide;

(racemic)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1-methylethyl)biphenyl-2-sulfonamide racemic;

4′

-(5-Aminopyrazin-2-yl)-N-(cyclobutylmethyl)-3′

-fluorobiphenyl-2-sulfonamide;

(racemic) -(endo)-4′

-(5-Aminopyrazin-2-yl)-N-bicyclo[221]hept-2-yl-3′

-fluorobiphenyl-2-sulfonamide racemic;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-methylcyclobutyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-(1 ,1-dimethylpropyl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1 ,1-dimethylethyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-cyclopentyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-ethyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-phenylethyl)biphenyl-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-(2,3-dihydro-1H-inden-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-3′

-fluorobiphenyl-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-3′

-fluorobiphenyl-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-1-phenylethyl]biphenyl-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1 -methylethyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-phenylbiphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-N-[(3S)-1-ethyl-2-oxoazepan-3-yl]-3′

-fluorobiphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(3S)-2-oxoazepan-3-yl]biphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(3S)-1-methyl-2-oxoazepan-3-yl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1 ,2,2,6,6-pentamethylpiperidin-4-yl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-pyridin-3-ylbiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfamide;

N-(4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)propane-2-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]ethanesulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]propane-1-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-2-methylpropane-1-sulfonamide;

N-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1 ,1-biphenyl]-2-yl)cyclopropanesulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]hexane-1-sulfonamide;

N-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)cyclobutanesulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1,1,1-trifluoromethanesulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N,N-dimethylbiphenyl-2-sulfonamide;

5-[3-Fluoro-2′

-(piperidin-1-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-[3-Fluoro-2′

-(morpholin-4-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-[3-Fluoro-2′

-(piperazin-1-ylsulfonyl)biphenyl -4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-sulfonamide;

5-8 3-Fluoro-2′

-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[(4,4-Difluoropipenclin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(3,3-Difluoropipenclin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(3,3-Difluoropyrrolidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(3,3-Difluoroazetidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-[2′

-(Azepan-1-ylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5-{3-Fluoro-2′

-[(4-methylpiperazin-1-0)sulfonyl]piphenyl-4-yl}pyrazin-2-amine;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-(trifluoromethyl)}pipendin-4-ol;

5-(3-Fluoro-2′

-{[4-(methylsulfonyl)piperazin-1-yl]sulfonyl}biphenyl-4-0)pyrazin-2-amine;

5-{2′

-[(4-Acetylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-(2′

-{[4-(Cyclopropylcarbonyl)piperazin-1-yl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine;

2-(4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-1-yl)ethanol;

5-{2′

-[(4-Cyclopropylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

(racemic) 5-[3-Fluoro-2′

-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[(3,5-Dimethylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

(racemic) 1 -{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidine-3-carbonitrile;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidine-4-carbonitrile;

5-{2′

-[(4-Aminopipenclin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-2-one;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-ol;

(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)methanol;

2-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)pethanol;

(racemic) 1 -{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-ol;

(racemic) 2-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)ethanol;

5-(3-Fluoro-2′

-{[4-(methylamino)piperidin-1-yl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine;

5-(2′

-{[4-(Dimethylamino)piperidin-1-yl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine;

(racemic) 5-{2′

-[(3-Aminopiperidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

N-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)acetamide;

(racemic) (1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)methanol;

(racemic) tert-Butyl (1-{[4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-3-yl)carbamate;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S,2S)-2-hydroxy-1-(hydroxymethyl)-2-phenylethyl]piphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]biphenyl- 2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxypropyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-phenylethyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-phenylethyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethyl]piphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R,2R)-2-hydroxycyclohexyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-1-(hydroxymethyl)propyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R,2S)-2-hydroxycyclohexyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-(cyclopropylmethyl)-3′

-fluorobiphenyl-2-sulfonamide;

(R)-(1((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro1 ,1′

-biphenyl]-2-yl)sulfonyl)pyrrolidin-2-yl)methanol;

(R)-5-(2′

4(3-Aminopyrrolidin-1-yl)sulfonyl)-3-fluoro-[1 ,1 biphenyl]-4-yl)pyrazin-2-amine;

(S)-5-(2′

4(3-Aminopyrrolidin-1-yl)sulfonyl)-3-fluoro-[1 ,1 biphenyl]-4-yl)pyrazin-2-amine;

(R) 5(2′

-{[2-(Aminomethyl)pyrrolidin-1-yl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrazin-2-amine;

(S)-(1-((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro41 ,1′

-biphenyl]-2-yl)sulfonyl)pyrrolidin-2-yl)methanol;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(methylsulfonyl)biphenyl-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxypropyl)41 ,1′

-biphenyl]-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxypropyl)41 ,1′

-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1-hydroxycyclohexyl)methyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxy-1 ,1-dimethylethyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxy-2-methylpropyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxy-1 ,1-dimethylpropyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-hydroxy-2,2-dimethylpropyl)biphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-N-(2,3-dihydroxypropyl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-N-(2,3-dihydroxypropyl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide;

(trans)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3,4-diol;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-oxopyrrolidin-3-yl)1,1′

-biphenyl]-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-oxopiperidin-3-yl)-1 ,1′

-biphenyl]-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[1-(hydroxymethyl)-2-methylpropyl]biphenyl-2-sulfonamide;

trans 4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl)biphenyl-2-sulfonamide;

(R)-(1-((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)pyrrolidin-3-yl)methanol;

(S)-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl)}pyrrolidin-3-yl)methanol;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-oxopiperidin-3-yl)biphenyl-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methyl-N-piperidin-3-yl)biphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methyl-N-piperidin-3-yl)biphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3-phenylpropan-2-yl)-1,1′

-biphenyl]-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxy-2-phenylethyl)-1,1′

-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-[1,1′

-biphenyl]-2-sulfonamide;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}azetidin-3-ol;

(racemic) (trans)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxycyclohexyl)biphenyl-2-sulfonamide;

(racemic) (trans)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N42-(hydroxymethyl)cyclohexyl]biphenyl-2-sulfonamide;

(racemic) (cis)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N42-(hydroxymethyl)cyclohexyl]biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-piperidin-4-ylbiphenyl-2-sulfonamide;

5-(2′

-{[3-(Aminomethyl)azetidin-1-yl]sulfonyl}-3-fluorobiphenyl-4-ly) pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N-(azetidin-3-ylmethyl)-3′

-fluorobiphenyl-2-sulfonamide;

(R)-5-(3-Fluoro-2′

-{[3-(methylamino)pyrrolidin-1-yl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1-methylethyl)biphenyl-2-sulfonamide;

5-[3-Fluoro-2′

-(1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

4-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperidin-4-yl)-2,4-dihydro-3H-1,2,4-triazol-3- one;

5-(2′

-((1R,4R)-2,5-Diazabicyclo[221]heptan-2-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine;

5-(2′

-((1S,4S)-2,5-Diazabicyclo[221]heptan-2-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(5-hydroxypentyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(6-hydroxyhexyl)biphenyl-2-sulfonamide;

N-(4-Aminocyclohexyl)-4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

(S)-(1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2,3-dihydro-1H-indol-2-yl)methanol;

4′

-(5-Aminopyrazin-2-yl)-N-cyclohexyl-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide;

(S)-5-{2′

-[(3-Aminopiperidin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N, N-bis(2-hydroxyethyl)biphenyl-2-sulfonamide;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}azetidine-2-carboxamide;

4′

-(5-Aminopyrazin-2-yl)-N-cyclopropyl-3′

-fluoro-N-(tetrahydro-2H-pyran-4-yl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)-N-(1-methylethyl)biphenyl-2-sulfonamide;

racemic (4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}morpholin-2-yl)methanol;

(1R,5S)-3-((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro- [1′

-biphenyl]-2-yl)sulfonyl)-3-azabicyclo[310]hexan-6-amine;

(S)-5-(3-Fluoro-2′

-((2-methylpiperazin-1 -yl)sulfonyl)1 ,1 ′

biphenyl]-4-yl)pyrazin-2-amine;

(R)-5-(3-Fluoro-2′

4(2-methylpiperazin-1-yl)sulfonyl)41 ,1 -biphenyl]-4-yl)pyrazin-2-amine;

(R)-(1-((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)piperazin-2-yl)methanol;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]biphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3-methylbutan-2-yl)-1,1′

-biphenyl]-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-[1, 1′

-biphenyl]-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxy-3,3-dimethylbutan-2-yl)[1,1′

-biphenyl]-2-sulfonamide;

tert-Butyl [2-({[4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}amino)ethyl]carbamate;

N-(2-Aminoethyl)-4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-hydroxybutan-2-yl)1,1′

-biphenyl]-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(pyrrolidin-3-yl)1, 1-biphenyl]-2-sulfonamide;

N-[2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}amino)ethyl]acetamide;

(S)-2-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro1,1′

-biphenyl]-2-ylsulfonamido)propanoic acid;

4′

-(5-Aminopyrazin-2-yl)-N-[2-(carbamoylamino)ethyl]-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-((1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-y1)1,1′

-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-((1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)[1,′

-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-[1, ″

-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-((1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)′

1 ,1-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-((1 S,2S)-2-hydroxycyclohexyl)40 ,1-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[6-(trifluoromethyl)pyridin-3-yl]biphenyl-2-sulfonamide;

5-(3-Fluoro-2′

-{[4-(1H-imidazol-4yl)piperidin-1-yl]sulfonyl}biphenyl-4-yl)pyrazin-2-amine;

N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4′

-(5-aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-(2,6-dimethoxypyrim idin-4-yl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(5-methylpyrazin-2-yl)biphenyl-2-sulfonamide;

(S)-2-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1 ,1′

-biphenyl]-2-ylsulfonamido)-4-methylpentanamide;

4′

-(5-Aminopyrazin-2-yl)-N-(2-cyanoethyl)-3′

-fluorobiphenyl-2-sulfonamide;

(R)-4′

-(5-Aminopyrazin-2-yl)-N-(1-cyanopropan-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-sulfonamide;

(S)-4′

-(5-Aminopyrazin-2-yl)-N-(1-cyanopropan-2-yl)-3′

-fluoro-[1 , l-biphenyl]-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-(2-cyanoethyl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(3-methyloxetan-3-yl)biphenyl-2-sulfonamide;

3-(4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-1-yl)propanenitrile;

(S)-4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(1-methoxypropan-2-041 ,1′

-biphenyl]-2-sulfonamide;

5-{3-Fluoro-2′

-[(4-pyrazin-2-ylpiperazin-1-yl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(4-pyrimidin-2-ylpiperazin-1-yl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine;

5-(2′

-Amino-3-fluorobiphenyl-4-yl)pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[1 -(hydroxymethyl)cyclopentyl]biphenyl-2-sulfonamide;

1 -{[4′

-(5-Aminopyrazin-2-0-3′

-fluorobiphenyl-2-yl]sulfonyl}-3-phenylpyrrolidin-3-ol;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrrolidine-1-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N,N-dimethylsulfamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]morpholine-4-sulfonamide;

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-3-ol;

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-3-ol;

(3′

S,4′

S)-1′

-{[4′

-(5-Aminopyrazin-2-0-3′

-fluorobiphenyl-2-yl]sulfonyl}-1 ,3′

-bipyrrolidin-4′

-ol;

(3S,4S)-1-{[4′

-(5-Aminopyrazin-2-0-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-morpholin-4-ylpyrrolidin-3-ol;

(3S,4S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-(4-methylpiperazin-1)pyrrolidin-3-ol;

5-{3-Fluoro-2′

-[(trifluoromethyl)-sulfanyl]biphenyl-4-yl}pyrazin-2-amine;

5[2′

-(tert-Butylsulfanyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5[2′

-(Ethylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5[3-Fluoro-2′

-(propylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-{3-Fluoro-2′

-[(2-methylpropyl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine;

5[2′

-(tert-Butylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5[2′

-(Cyclopentylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5[2′

-(Cyclobutylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5[2′

-(Cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5[3-Fluoro-2′

-(hexylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-{3-Fluoro-2′

-[(1-methylethyl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}acetamide;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}-N, N-diethylacetamide;

5-{3-Fluoro-2′

-[(2-morpholin-4-yl-2-oxoethyl)sulfanyl]biphenyl-4-yl}pyrazin-2-amine;

(racemic) 5-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}methyl)-1 ,3-oxazolidin-2-one;

N-(2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}ethyl)benzamide;

5-(3-Fluoro-2′

-{[4-(methylsulfonyl)benzyl]sulfanyl}biphenyl-4yl)pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide;

5[3-Fluoro-2′

-(methylsulfonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methyl-4-(trifluoromethyl)biphenyl-2-sulfonamide;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]sulfonyl}piperazin-2-one;

4′

-(5-aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)-4-(trifluoromethyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-ethyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide;

5-{3-Fluoro-2′

-[(4-methylpiperazin-1-yl)sulfonyl]-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazin-2-amine;

5[3-Fluoro-2′

-(pyrimidin-2-ylsulfanyl)biphenyl-4-yl]pyrazin-2-amine;

5[3-Fluoro-2′

-(pyrimidin-4-ylsulfanyl)biphenyl-4-yl]pyrimidin-2-amine;

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-4-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-4-amine;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-5-amine;

5[3-Fluoro-2′

-(pyrazin-2-ylsulfanyl)biphenyl-4-yl]pyrazin-2-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-5-amine;

1[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methylmethanesulfonamide;

1[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-(2-hydroxyethyl)methanesulfonamide;

1-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)azetidin-3-ol;

4-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)piperazin-2-one;

(S)-1-(4′

45-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)-N-(1-hydroxypropan-2-yl)methanesulfonamide;

(R)-1-(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)-N-(1-hydroxypropan-2-yl)methanesulfonamide;

1 -[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-(trans-4-hydroxycyclohexyl)methanesulfonamide;

(S)-1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-[(2S)-2-hydroxypropyl]methanesulfonamide;

(R)-1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-[(2S)-2-hydroxypropyl]methanesulfonamide;

5-(2′

-{[(4-Aminopiperidin-1-yl)sulfonyl]methyl1-3-fluorobiphenyl-4-}pyrazin-2-amine;

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methanesulfonamide;

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-ethylmethanesulfonamide;

1-[1-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)piperidin-4-yl]urea;

N- [1-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfonyl)piperidin-4-yl]acetamide;

5-{2′

-[(Ethylsulfanyl)methyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(methylsulfanyl)methyl]biphenyl-4-yl}pyrazin-2-amine;

5-(3-Fluoro-2′

-{[(1-methylethyl)sulfanyl]methyl}biphenyl-4-yl)pyrazin-2-amine;

2-(((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro41 ,1′

-biphenyl]-2-yl)methyl)thio)pyrimidin-4-amine;

6-(((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro41 ,1′

-biphenyl]-2-yl)methyl)thio)pyrimidin-4-amine;

5-(3-Fluoro-2′

-((pyridazin-3-ylthio)methyl)41 ,1′

-biphenyl]-4-yl)pyrazin-2-amine;

6-(((4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro41 ,1 -biphenyl]-2-yl)methyl)thio)pyridazin-3-amine;

5-{2′

-[(1 ,1 -Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-2-amine;

5-(3-Fluoro-2′

-((pyrimidin-4-ylthio)methyl)41 ,1′

-biphenyl]-4-yl)pyrazin-2-amine;

5[3-Fluoro-2′

-({[2-(trimethylsily)ethoxy]methyl}sulfanyl)biphenyl-4-yl]pyrazin-2-amine;

5[3-Fluoro-2′

-({[2-(trimethylsily)ethoxy]methyl}sulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-(3-Fluoro-2′

-{[3-(methylsulfonyl)propyl]sulfonyl}biphenyl)-4-pyrazin-2-amine;

5-(3-Fluoro-2′

-{[(2R)-2-methylpiperazin-1-yl]sulfonyl}biphenyl-4-yl)pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)propyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-N-(2-cyanoethyl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-N-(2-cyanoethyl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(3-hydroxy-2,2-dimethylpropyl)biphenyl-2-sulfonamide;

(racemic) (4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-sulfonyl}morpholin-2-yl)methanol;

5-(3-Fluoro-2′

-{[(2S)-2-methylpiperazin-1-yl]sulfonyllbiphenyl-4-Opyrimidin-2-amine;

5[2′

-(Cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[2-hydroxy-1-(hydroxymethyl)-1-biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-methyl-N-[(3S)-piperidin-3-yl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-methyl-N-[(3R)-piperidin-3-yl]biphenyl-2-sulfonamide;

[(2R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-2-yl]methanol;

(racemic) (cis) 4′

-(2-Aminopyrimidin-5-0-3′

-fluoro-N- (cis)-2-hydroxycyclohexylpiphenyl-2- sulfonamide;

(racemic) (trans) 4′

-(2-Aminopyrimidin-5-0-3′

-fluoro-N- (trans)-2-hydroxycyclohexylpiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)-N-(1-methylethyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(trans-4-hydroxycyclohexyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(3S)-2-oxopyrrolidin-3-yl]biphenyl-2-sulfonamide;

5-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}azetidin-3-ol;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(3R)-2-oxopiperidin-3-yl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(3S)-2-oxopiperidin-3-yl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1 R)-2,2,2-trifluoro-1 -methylethyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1 R)-1-(hydroxymethyl)-2,2-dimethylpropyl]piphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]piphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxy-2-methylpropyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1 R)-1-(hydroxymethyl)-2-methylpropyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-N-[(2S)-2, 3-dihydroxypropyl]-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide;

[(2R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-2-yl]methanol;

[(2S)-1 -{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidin-2-yl]methanol;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(2R)-2-hydroxypropyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(2S)-2-hydroxypropyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxy-1 ,1 -dimethylethyl)biphenyl-2-sulfonamide;

5-{2′

-[(4-Cyclopropylpiperazin-1-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

2-(4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-1-yl)ethanol;

4′

-(2-Aminopyrimidin-5-yl)-N-(cyclopropylmethyl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-N-cyclopropyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-phenylbiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)--N-tert-butyl-3′

-fluoro-3-methylbiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1 R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

5-[3-Fluoro-2′

-(piperazin-1 -ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1 R)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-phenylethyl]biphenyl-2-sulfonamide;

5[2′

-(tert-Butylsulfonyl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-methylpropyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-N-ethyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Aminopyrim idin-5-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1 ,1-dimethylethyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-sulfonamide;

5-[3-Fluoro-2′

-(pyrrolidin-1 -ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N,N-dimethyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-sulfonamide;

5-[3-Fluoro-2′

-(piperidin-1 -ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-sulfonamide;

5[3-Fluoro-2′

-(morpholin-4-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

5[3-Fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-N-(tert-butyl)-3′

-fluoro-[1, 1′

-biphenyl]-2-sulfonamide;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}piperazin-2-one;

tert-Butyl N-{[4′

-(2-aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-L- alaninate;

N-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-L-alanine;

N-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]pyrrolidine-1-sulfonamide;

N-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]morpholine-4-sulfonamide;

N′

-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]-N,N-dimethylsulfamide;

5-(2′

-(2-Oxa-6-azaspiro[33]heptan-6-ylsulfonyl)-3-fluoro-[1 ,1′

-biphenyl]-4-yl)pyrimidin-2-amine;

6-((4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)-2-thia-6-azaspiro[33]heptane 2,2-dioxide;

1-((4′

-(2-Aminopyrim ,1′

-biphenyl]-2-yl)sulfonyl)azetidine-3-carbonitrile;

1-((4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-[1 , l-biphenyl]-2-yl)sulfonyl)-3-(trifluoromethyl)azetidin-3-ol;

5-{2′

-[(1 ,1-Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

2-(((4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-yl)sulfonyl)methyl)quinazolin-4(3H)-one;

1-(34(4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-[1 ,1′

-biphenyl]-2-yl)sulfonyl)propyl)-1H-benzo[d]imidazol-2(3H)-one;

5-(2′

-{[3-(Cyclohexylsulfonyl)propyl]sulfonyl}1-3-fluorobiphenyl-4yl}pyrimidin-2-amine;

5-{3-Fluoro-2′

-[(1-methyl-1H-benzimidazol-2-yl)sulfonyl]biphenyl-4-yl}pyrimidin-2-amine;

5-(2′

-{[(3-Cyclopropyl-1 ,2,4-oxadiazol-5-yl)methyl]sulfonyl}-3-fluorobiphenyl-4-yl)pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide;

5[3-Fluoro-2′

-(methylsulfonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrimidin-2-amine;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]sulfonyl}piperazin-2-one;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-methyl-4-(trifluoromethyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)-4-(trifluoromethyl)biphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-N-ethyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide;

5-{3-Fluoro-2′

-[(4-methylpiperazin-1-yl)sulfonyl]-4′

-(trifluoromethyl)biphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(5-Aminopyrimidin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(4-Aminopyrimidin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(5-Aminopyrimidin-4-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5[3-Fluoro-2′

-(pyrimidin-2-ylsulfanyl)biphenyl-4-yl]pyrimidin-2-amine;

5[3-Fluoro-2′

-(pyrazin-2-ylsulfanyl)biphenyl-4-yl]pyrimidin-2-amine;

5-{2′

-[(6-Aminopyrimidin-4-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

4-{[’

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrimidin-2-amine;

5-{2′

-[(6-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(5-Aminopyrimidin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5{3-Fluoro-2′

-({[2-(trimethylsilypethoxy]methyl}sulfonyl)biphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(5-Aminopyrimidin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5{3-Fluoro-2′

-({[2-(trimethylsilyl)ethoxy]methyl}sulfanyl)biphenyl-4-yl}pyrimidin-2-amine;

5-(3-Fluoro-Z-(methylsulfonyl)41 ,1′

-biphenyl]-4-yl)pyridin-2-amine;

4′

-(6-Aminopyridin-3-yl)-N-(tert-butyl)-3′

-fluoro-[1 ,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-N,N-diethyl-3′

-fluoro-[1 , l-biphenyl]-2-sulfonamide;

5-(3-Fluoro-2′

-(pyrrolidin-1 -ylsulfonyl)41 ,1′

-biphenyl]-4-yl)pyridin-2-amine;

5-(3-Fluoro-2′

-(piperidin-1 -ylsulfonyl)41 ,1′

-biphenyl]-4-yl)pyridin-2-amine;

4′

-(6-Aminopyridin-3-yl)-N-cyclohexyl-3′

-fluoro-[l,1′

-biphenyl]-2-sulfonamide;

(S)-4′

-(6-Aminopyridin-3-yl)-3-fluoro-N-(1-hydroxypropan-2yl)-1,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-isobutyl-[l ,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(tert-pentyl)-[1 ,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(1 ,1 ,1-trifluoro-2-methylpropan-2-yl)41 ,t-biphenyl]-2-sulfonamide;

(S)-4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(2,2,2-trifluoro-1-phenylethyl)-[1 ,1′

-biphenyl]-2-sulfonamide;

(R)-4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(1-hydroxypropan-2-yl)41 ,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(1-methylcyclobutyl)-[1 ,1′

-biphenyl]-2-sulfonamide;

4-((4′

-(6-Aminopyridin-3-yl)-3′

-fluoroql ,1′

-biphenyl]-2-yl)sulfonyl)thiomorpholine1,1-dioxide;

(S)-4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(1 ,1 ,1-trifluoropropan-2-yl)41 ,1′

-biphenyl]-2-sulfonamide;

5-(2′

-((1S,4S)-2-Oxa-5-azabicyclo[221]heptan-5-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyridin-2-amine;

tert-Butyl 34(4′

-(6-aminopyridin-3-yl)-3′

-fluoro-[1 ,1′

-biphenyl]-2-ylsulfonamido)methyl)-3-hydroxyazetidine-1-carboxylate;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-((3-hydroxyazetidin-3-yl)methyl)-[1,1′

-biphenyl]-2-sulfonamide;

2-(1-((4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-[1 ,t-biphenyl]-2-yl)sulfonyl)piperidin-4-y1)ethanol;

1 -((4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-[1 ,1′

-biphenyl]-2-yl)sulfonyl)piperidin-4-ol;

(1-((4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-[1 ,1′

-biphenyl]-2-yl)sulfonyl)piperidin-4-y1)methanol;

3′

-Fluoro-N-[(1S)-2-hydroxy-1-methylethyl]-4′

41 H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide;

3′

-Fluoro-N-[(1 R)-2-hydroxy-1-methylethyl]-4′

-(1H-pyrrolo[2,3-b]pyridin-5-y1)biphenyl-2-sulfonamide;

3′

-Fluoro-N-[(3S)-2-oxopyrrolidin-3-yl]-4′

-(1 H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide;

5-[2′

-(Cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]-1 H-pyrrolo[2,3-b]pyridine;

3′

-Fluoro-N-(2-hydroxyethyl)-4′

-(1 H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(1 H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide;

3′

-Fluoro-4′

-(1 H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide;

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]methanesulfonamide;

3′

-Fluoro-N, N-dimethyl-4′

-(5H-pyrrolo[2, 3-b]pyrazin-2-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide;

2-[3-Fluoro-2′

-(pyrrolidin-1 -ylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine;

N,N-Diethyl-3′

-fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide;

2-[3-Fluoro-2′

-(piperidin-1 -ylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine;

2-[3-Fluoro-2′

-(morpholin-4-ylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine;

3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)N--N-(2,2,2-trifluoro-1 -methylethyl)biphenyl-2-sulfonamide;

2-[3-Fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2, 3-b]pyrazine;

3′

-Fluoro-N-[(1 R)-2-hydroxy-1-methylethyl]-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-sulfonamide;

3′

-Fluoro-N-methyl-4′

-(5H-pyrrolo[2, 3-b]pyrazin-2-yl)biphenyl-2-sulfonamide;

3′

-Fluoro-N-[(1 S)-2-hydroxy-1-methylethyl]-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2- sulfonamide;

1 -{[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]sulfonyllpiperidin-4-amine;

2-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}-5H-pyrrolo[2,3-b]pyrazine;

2-[3,5′

-Difluoro-2′

-(methylsulfanyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine;

2-[2′

-(Ethylsulfanyl)-3-fluorobiphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine;

7-[3-Fluoro-2′

-(methylsulfonyl)biphenyl-4-yl]-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine;

7-[3-Fluoro-2′

-(piperidin-1 -ylsulfonyl)biphenyl-4-yl]-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine;

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

1 -{[4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1 ,4]oxazin-7-yl)-3′

-fluorobiphenyl-2-yl]sulfonyllpiperidin-4-amine;

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1 ,4]oxazin-7-yl)-3′

-fluoro-N-[(1 R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

4′

-(3,4-Dihydro-2H-pyrido[3,2-b][1 ,4]oxazin-7-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-sulfonamide;

7-{2′

-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}-3,4-dihydro-2H-pyrido[3,2-b][1 ,4]oxazine;

N-tert-Butyl-4′

-(3,4-dihydro-2H-pyrido[3,2-b][1 ,4]oxazin-7-yl)-3′

-fluorobiphenyl-2-sulfonamide;

2-(2-Fluoro-4-{2-[(1-methylethyl)sulfanyl]-5-(trifluoromethyl)pyridin-3-yl}phenyl)-5H-pyrrolo[2,3-b]pyrazine;

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine;

5-(2-Fluoro-4-{2-[(1-methylethyl)sulfanyl]pyridin-3-yl}phenyl)pyrazin-2-amine;

2-{2-Fluoro-4[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]phenyl}-5H-pyrrolo[2,3-b]pyrazine;

2-{2-Fluoro-4[2-(2-methylpropoxy)pyridin-3-yl]phenyl}-5H-pyrrolo[2,3-b]pyrazine;

2-{2-Fluoro-4[2-(1-methylethoxy)pyridin-3-yl]phenyl}-5H-pyrrolo[2,3-b]pyrazine;

2-{4-[2-(Cyclopropylmethoxy)pyridin-3-yl]-2-fluorophenyl}-5H-pyrrolo[2,3-b]pyrazine;

5-{4-[2-Fluoro-4-[2-(1-methylethoxy)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-{4[2-(Cyclopentyloxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine;

5-{2[2-(Cyclohexyloxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine;

5-[2-Fluoro-4-(2-methoxypyridin-3-yl)phenyl]pyrazin-2-amine;

5-{4-[2-(Cyclobutyloxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-am ine;

tert-Butyl 3-[({3-[4-(5-aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)methyl]pyrrolidine-1-carboxylate;

5-{2-Fluoro-4-[2-(pyrrolidin-3-ylmethoxy)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-{2-Fluoro-4-[2-(1-methylethoxy)pyridin-3-yl]phenyl}pyrimidin-2-amine;

5-[4-(2-Aminopyridin-3-yl)-2-fluorophenyl]pyrim idin-2-am ine;

4′

-(5-Amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

3-Amino-642′

-(cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carbonitrile;

4′

-(5-Amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

4′

-(5-Amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide;

3-Amino-6-{3-fluoro-2′

-[(3-oxopiperazin-1-yl)sulfonyl]biphenyl-4-yl}pyrazine-2-carbonitrile;

4′

-(5-Amino-6-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2R)-2-hydroxypropyl]biphenyl-2-sulfonamide;

3-Amino-643-fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]pyrazine-2-carbonitrile;

4′

-(6-Aminopyridazin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(1 ,8-naphthyridin-3-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-quinoxalin-6-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(1 H-indo1-5-yl)biphenyl-2-sulfonamide;

4′

-(1 H-Benzimidazol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(1 H-Benzimidazol-5-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide;

4′

-(1,3-Benzothiazol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(1 H-pyrrolo[3,2-b]pyridin-6-yl)biphenyl-2-sulfonamide;

3′

-Fluoro-N-methyl-4′

-(1 H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyridin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-4′

-(5,6-diaminopyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(2-oxo-2,3-dihydro-1 H-imidazo[4,5-b]pyrazin-5-yl)biphenyl-2-sulfonamide;

4′

-(6-Amino-5-fluoropyridin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonam ide;

N-tert-Butyl-4′

-(2,3-dihydro-1 H-pyrrolo[2,3-b]pyridin-5-yl)-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(3H-im idazo[4, 5-b]pyridin-6-yl)bipheyl-2-sulfonamide;

4′

-(5-Amino-6-methoxypyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Amino-6-cyanopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Amino-3-cyanopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(6-Amino-4-cyanopyridin-3-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(6-Amino-2-cyanopyridin-3-yl)-N-(tert-butyl)-3′

-fluoroql ,t-biphenyl]-2-sulfonamide;

4′

-(5-Amino-1 ,3,4-thiadiazol-2-yl)-N-(tert-butyl)-3′

-fluoroql ,1′

-biphenyl]-2-sulfonamide;

(R)-4′

-(5-Amino-1 ,3,4-thiadiazol-2-yl)-3′

-fluoro-N-(1-hydroxypropan-2-yl)41 ,t-biphenyl]-2-sulfonamide;

4-((4′

-(5-Amino-1 ,3,4-thiadiazol-2-yl)-3′

-fluoro41 ,1′

-biphenyl]-2-yl)sulfonyl)thiomorpholine 1 ,1 -dioxide;

4′

-(5-Amino-6-chloropyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Amino-6-bromopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

6-Amino-3-(2′

-(cyclopropylsulfonyl)-3-fluoro41 ,1′

-biphenyl]-4-yl)picolinonitrile;

N-tert-Butyl-3′

-fluoro-4′

41 ,2,4]triazolo[4,3-a]pyridin-7-ylbiphenyl-2-sulfonamide;

4′

-(5-Amino-6-methylpyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Amino-6-methylpyrazin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(1H-imidazo[4,5-b]pyrazin-5-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-4′

-(5,6-diaminopyridin-3-yl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Amino-6-methylpyrazin-2-yl)-3′

-fluoro-N-methylbiphenyl-2-sulfonamide;

4′

-(6-Amino-5-cyanopyridin-3-yl)--N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(6-Amino-5-chloropyridin-3-yl)--N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]--N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-[2-Amino-4-(trifluoromethyl)pyrimidin-5-yl]-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Amino-4-methylpyrimidin-5-yl)--N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-[3-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]biphenyl-2-sulfonamide;

4′

-(7-Amino-1 H-indo1-5-yl)-3′

-fluoro-N41 -(hydroxymethyl)cyclopentyl]biphenyl-2-sulfonamide;

3′

-Fluoro-4′

-[3-(hydroxymethyl)-1 H-pyrrolo[2,3-b]pyridin-5-yl]-N-methylbiphenyl-2-sulfonamide;

4′

-(7-Amino-1 H-indol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]acetamide;

1 44′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]urea;

5-[2,3-D ifluoro-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-2′

,3′

-difluorobiphenyl-2-sulfonamide;

N-[4′

-(5-Am nopyrazin-2-yl)-3′

-fluoro-2′

-methylbiphenyl-2-yl]methanesulfonam ide;

4′

-(5-Aminopyrazin-2-yl)-2′

,3′

-difluorobiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)-2′

,3′

-difluoro-N-methylbiphenyl-2-sulfonamide;

4′

-(2-Aminopyrimidin-5-yl)--N-tert-butyl-2′

,3′

-difluorobiphenyl-2-sulfonamide;

5 [2′

,3-Difluoro-4′

-(trifluoromethoxy)biphenyl-4-yl]pyrazin-2-amine;

5-(2′

,3-Difluorobiphenyl-4-yl)pyrazin-2-amine;

5-(2′

-Chloro-3-fluorobiphenyl-4-yl)pyrazin-2-amine;

5-(3-Fluoro-2′

-methylbiphenyl-4-yl)pyrazin-2-amine;

5[2′

,3-Difluoro-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

5[3-Fluoro-2′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

5-(3-Fluoro-2′

-methoxybiphenyl-4-yl)pyrazin-2-amine;

5-[3-Fluoro-2′

-(methylsulfanyl)biphenyl-4-yl]pyrazin-2-amine;

5-[3-Fluoro-2′

-(trifluoromethoxy)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-ol;

5-[3-Fluoro-2′

-(phenylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5-(2′

,3,6′

-Trifluorobiphenyl-4-yl)pyrazin-2-amine;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]benzenesulfonamide;

5-(2′

-Ethyl-3-fluorobiphenyl-4-yl)pyrazin-2-amine;

{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetic acid;

5-[3-Fluoro-2′

-(1-methylethyl)biphenyl-4-yl]pyrazin-2-amine;

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]ethanone;

5-[3-Fluoro-2′

-(2,2,2-trifluoroethoxy)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-carboxylicacid;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-carboxamide;

5-[3-Fluoro-2′

-(1-methylethoxy)biphenyl-4-yl]pyrazin-2-amine;

5-{442-(Cyclopropylmethoxy)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine;

2-[3,4′

-Difluoro-2′

-(methylsulfonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methylmethanesulfonmide;

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]ethanesulfonamide;

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]N--N-methylmethanesulfonamide;

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]-N-methylethanesulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methylethanesulfonam ide;

N-[3′

-Fluoro-4′

-(5H-pyrrolo[2,3-b]pyrazin-2-yl)biphenyl-2-yl]-2-methylpropane-1-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-ethylmethanesulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N,2-dimethylpropane-1 -sulfonamide;

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]-1 H-pyrrolo[2,3-b]pyridine;

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]pyrimidin-2-amine;

2-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]-5H-pyrrolo[2,3-b]pyrazine;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-carboxamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

,4-difluorobiphenyl-2-carboxamide;

4′

-(5-Aminopyrazin-2-yl)-N, N-diethyl-3′

-fluorobiphenyl-2-carboxamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide;

5-[3-Fluoro-2′

-(piperazin-1 -ylcarbonyl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[(4-Acetylpiperazin-1-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N-cyclohexyl-3′

-fluorobiphenyl-2-carboxamide;

5-{2′

-[(1 ,1 -Dioxidothiomorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-methylbiphenyl-2-carboxamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]biphenyl-2-carboxamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-carboxamide;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-4-ol;

5-{2′

-[(4-Aminopiperidin-1 -yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(1 ,1 -Dioxidothiomorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-carboxamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-[(1R)-2,2,2-trifluoro-1-methylethyl]biphenyl-2-carboxamide;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperazin-2-one;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperazin-2-one;

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrimidin-2-amine;

4-{[3′

-Fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-yl]oxy}pyrimidin-2-amine;

2-{[3′

-Fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-yl]oxy}pyrimidin-4-amine;

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]-1 H-pyrrolo[2,3-b]pyridine;

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]pyrazin-2-amine;

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]pyrimidin-2-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-4-amine;

5-{2′

-[(4-Aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

6-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}methyl)pyridine-2-carbonitrile;

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}methyl)pyridine-3-carbonitrile;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-2-amine;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-2-amine;

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-4-amine;

5-{2′

-[(6-Aminopyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile;

5-{2′

-[(6-Azetidin-1-ylpyrim idin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(6-Azetidin-1-ylpyrim idin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{3-Fluoro-2′

-[(2-methylpyrimidin-4-yl)oxy]biphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(2-methylpyrimidin-4-yl)oxy]biphenyl-4-yl}pyrimidin-2-amine;

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]-1H-benzimidazole;

6-[3-Fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]-3H-imidazo[4,5-b]pyridine;

5-{3-Fluoro-2′

-[(4-methylpyrimidin-2-yl)oxy]biphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(4-methylpyrimidin-2-yl)oxy]biphenyl-4-yl}pyrimidin-2-amine;

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyrim idin-4-yl]oxy}biphenyl-4-yl}pyrazin-2-amine;

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyrim idin-4-yl]oxy}biphenyl-4-yl}pyrimidin-2-amine;

5-{3-Fluoro-2′

-[(5-methoxypyrimidin-2-yl)oxy]biphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(5-methoxypyrimidin-2-yl)oxy]biphenyl-4-yl}pyrimidin-2-amine;

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

5-[3-Fluoro-2′

-(pyrimidin-2-yloxy)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrimidin-2-amine;

5-[3-Fluoro-2′

-methoxy-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-ol;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]oxy}pyrimidin-2-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]oxy}pyrimidin-4-amine;

5-[3-Fluoro-4′

-(trifluoromethyl)-2′

-{[2-(trimethylsilyl)ethoxy]methoxy}biphenyl-4-yl]pyrimidin-2-amine;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-ol;

5-{2′

-[(4-Aminopyrimidin-2-yl)oxy]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrimidin-2-amine;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]oxy}pyrimidin-2-amine;

5-{2′

-[(6-Aminopyrimidin-4-yl)oxy]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrimidin-2-amine;

5-[3-Fluoro-2′

,4′

-bis(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carbonitrile;

5-{5-[2-(Pyrimidin-2-yloxy)-4-(trifluoromethyl)phenyl]pyridin-2-yl}pyrimidin-2-amine;

4-{2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-5-(trifluoromethyl)phenoxy}pyrimidin-2-amine;

5-{5-[2-(Pyrimidin-2-yloxy)phenyl]pyridin-2-yl}pyrimidin-2-amine;

4-{2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]phenoxy}pyrimidin-2-amine;

5-(5-{2-[(4-Aminopyrimidin-2-yl)oxy]phenyl}pyridin-2-yl)pyrimidin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-methylbiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-methoxybiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butylbiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N,N-dimethylbiphenyl-2-sulfonamide;

5[2′

-(Morpholin-4-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-2′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-2′

-fluoro-N,N-dimethylbiphenyl-2-sulfonamide;

4′

-(2-Amino-1,3-oxazol-4-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Amino-1,3-thiazol-4-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(2-Amino-1,3-thiazol-4-yl)-N,N-diethyl-3′

-fluorobiphenyl-2-sulfonamide;

4-[3-Fluoro-2′

-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl]-1,3-thiazol-2-amine;

N-tert-Butyl-3′

-fluoro-4′

-(8-fluoroimidazo[1,2-a]pyridin-2-yl)biphenyl-2-sulfonamide;

4′

-(5-Aminoimidazo[1,2-a]pyridin-2-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

2-[2′

-(tert-Butylsulfamoyl)-3-fluorobiphenyl-4-yl]imidazo[1,2-a]pyridine-6-carboxamide;

2-[2′

-(tert-Butylsulfamoyl)-3-fluorobiphenyl-4-yl]imidazo[1,2-a]pyridine-6-carboxamide;

N-tert-Butyl-4′

-(5-cyanoimidazo[1,2-a]pyridin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-4′

-(6-cyanoimidazo[1,2-a]pyridin-2-yl)-3′

-fluorobiphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

46-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]biphenyl-2-sulfonamide;

Ethyl 2-[2′

-(tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl]imidazo[1,2-a]pyridine-5-carboxylate;

N-tert-Butyl-3′

-fluoro-4′

-(5-methoxyimidazo[1,2-a]pyridin-2-yl)biphenyl-2-sulfonamide;

5[2′

-(Methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

5[3-Methyl-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N,N,3′

-trimethylbiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-3′

-hydroxybiphenyl-2-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)biphenyl-2-yl]methanesulfonamide;

4′

-(5-Aminopyrazin-2-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-3′

-fluoro-4′

-(2-oxo-2,3-dihydro-1 H-indol-5-yl)biphenyl-2-sulfonamide;

N-tert-Butyl-4′

-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(3-Amino-1 H-indazol-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

3-Amino-6-[2′

-(tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carboxylic acid;

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}acetamide;

2-{[4′

-(2-Aminopyrimidin-5-0-3′

-fluorobiphenyl-2-yl]sulfonyl}-N,N-diethylacetamide;

5-{3-Fluoro-2′

-[(2-morpholin-4-yl-2-oxoethyl)sulfonyl]biphenyl-4-yl}pyrimidin-2-amine;

5,5′

-(3,3″

-Difluoro-1,1′

;

2′

,1″

-terphenyl-4,4″

-diyl)dipyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carboxylic acid;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-carbaldehyde;

5-[3-Fluoro-2′

-(morpholin-4-ylmethyl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[(4-Aminopiperidin-1-yl)methyl]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazin-2-amine;

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol;

5-{2′

-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yllpyrazin-2-amine;

5-{2′

-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yllpyrimidin-2-amine;

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyridin-4-yl]oxy}biphenyl-4-Opyrazin-2-amine;

5-(3-Fluoro-2′

-{[2-(trifluoromethyl)pyridin-4-yl]oxy}biphenyl-4-Opyrimidin-2-amine;

5-(3-Fluoro-2′

-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}biphenyl-4-Opyrazin-2-amine;

5-(3-Fluoro-2′

-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}biphenyl-4-Opyrimidin-2-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyrimidin-5-amine;

5-{2′

-[(5-Aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}-6-methylpyrim idin-4-amine;

5-{2′

-[(4-Amino-6-methylpyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

6-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile;

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-2-carbonitrile;

5-{2′

-[(5-Aminopyridin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(5-Aminopyridin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(6-Amino-2-methylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}-2-methylpyrim idin-4-amine;

5-(3-Fluoro-2′

-{[6-(trifluoromethyl)pyridin-2-yl]oxy}biphenyl-4-yl)pyrimidin-2-amine;

5-(3-Fluoro-2′

-{[6-(trifluoromethyl)pyridin-2-yl]oxy}biphenyl-4-yl)pyrazin-2-amine;

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile;

6-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}pyridine-3-carbonitrile;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}ethanol;

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}ethanol;

5(3-Fluoro-2′

-(piperidin-4-yloxy)biphenyl-4-yl]pyrazin-2-amine;

5(3-Fluoro-2′

-(piperidin-4-yloxy)biphenyl-4-yl]pyrimidin-2-amine;

5-{3-Fluoro-2′

-[(3R)-piperidin-3-yloxy]biphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(3R)-piperidin-3-yloxy]biphenyl-4-yl}pyrimidin-2-amine;

5-{3-Fluoro-2′

-[(3S)-piperidin-3-yloxy]biphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(3S)-piperidin-3-yloxy]biphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(6-Cyclopropylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(6-Cyclopropylpyrimidin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(2-Aminopyridin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(2-Aminopyridin-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-[2′

-(2-Aminoethoxy)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5-[2′

-(2-Aminoethoxy)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine;

{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetonitrile;

{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetonitrile;

{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}acetic acid;

5-{2-Fluoro-4-[2-(piperidin-4-yl]oxy)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-{2-Fluoro-4-[2-(piperidin-4-yloxy)pyridin-3-yl]phenyl}pyrimidin-2-amine;

5-(4-{2-[(1 ,1 -Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]pyridin-3-yl]-2-fluorophenyl)pyrazin-2-amine;

5-(4-{2-[(1 ,1 -Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]pyridin-3-yl]-2-fluorophenyl)pyrimidin-2-amine;

2-({3-[4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)ethanol;

2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)ethanol;

5-(4-{2-[(trans-4-Aminocyclohexyl)oxy]pyridin-3-yl1-2-fluorophenyl)pyrim idin-2-amine;

5-(4-{2-[(trans-4-Aminocyclohexyl)oxy]pyridin-3-yl}-2-fluorophenyl)pyrazin-2-amine;

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]phenyl}pyrimidin-2-amine;

(2R)-2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-ol;

(2R)-2-({344-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-01;

(2S)-2-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-o1;

(21)-2-({344-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-yl}oxy)propan-1-01;

N-(4′

-(6-Aminopyridin-3-yl)-3′

-fluoro41 ,1′

-biphenyl]-2-yl)methanesulfonamide;

5-(3-Fluoro-2′

-(morpholinosulfonyl)41 ,t-biphenyl]-4-yl)pyridin-2-amine;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-methyl41 ,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoroql ,1′

-biphenyl]-2-sulfonamide;

5-(2′

-((1S,4S)-2-Oxa-5-azabicyclo[221]heptan-5-ylsulfonyl)-3-fluoro-[1,1′

-biphenyl]-4-yl)pyridin-2-amine;

4′

-(6-Aminopyrazin-2-yl)-3′

-fluoro-N-((3-hydroxyazetidin-3-yl)methyl)41 ,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-(1-hydroxy-2-methylpropan-2-yl)41 ,t-biphenyl]-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-[1,1′

-biphenyl]-2-sulfonamide;

4′

-(6-Amino-5-fluoropyridin-3-yI)-3′

-fluoro-N-(1 -hydroxy-2-methylpropan-2-yI)-[1 ,t-biphenyl]-2-sulfonamide;

(racemic)-1-((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-[1,1′

-biphenyl]-2-y1)sulfonyl)piperidin-3-ol;

4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-[1,1′

-biphenyl]-2- sulfonamide;

N-(1 -((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro41 ,1′

-biphenyI]-2-yl)sulfonyl)piperidin-4-yl)acetamide;

racemic 2-[1 -((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoroql ,t-biphenyl]-2-yl)sulfonyl)piperidin-3-yl)ethanol;

racemic 1 -((4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-[l ,1′

-biphenyI]-2-yl)sulfonyl)piperidin-3-yl)methanol;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(2R)-2-hydroxypropyl]benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-ethyl-5-(trifluoromethyl)benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-tert-butylbenzenesulfonamide;

5-{5-[2-(Morpholin-4-ylmethyl)-4-(trifluoromethyl)phenyl]pyridin-2-yl}pyrimidin-2-amine;

5-{5-[2-(Morpholin-4-ylcarbonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine;

5-[5-(2-Methoxyphenyl)pyridin-2-yl]pyrimidin-2-amine;

5-(5-{2-[(3,3-Difluoropiperidin-1 -yl)sulfonyl]phenyl]pyridin-2-yl)pyrimidin-2-amine;

5-(5-{2-[(3,3-Difluoropyrrolidin-1-yl)sulfonyl]phenyl]pyridin-2-yl)pyrimidin-2-amine;

5-{5-[2-(Azepan-1-yl)sulfonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine;

5-(5-{2-[(4,4-Difluoropiperidin-1 -yl)sulfonyl]phenyl}pyridin-2-yl)pyrimidin-2-amine;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-ethylbenzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-(dicyclopropylmethyl)benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1 R)-2,2,2-trifluoro-1 -methylethyl]benzenesulfonamide;

4-({2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]phenyl}sulfonyl)piperazin-2-one;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(2S)-2-hydroxypropyl]benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(2R)-2-hydroxypropyl]benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N -(2-hydroxyethyl)-5-(trifluoromethyl)benzenesulfonamide;

5-{5-[2-(Cyclopropylsulfonyl)phenyl]pyridin-2-yl}pyrimidin-2-amine;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-ethyl-5-(trifluorom ethyl)benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-tert-butylbenzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-N-[(1 R)-2-hydroxy-1 -methylethyl]benzenesulfonamide;

3-Amino-6-{2′

-[(4-aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile;

5-(4′

-Bromo-2′

, 3-difluorobiphenyl-4-yl)pyrazin-2-amine;

5-(4′

-Bromo-2′

,3-difluorobiphenyl-4-yl)-1 H-pyrrolo[2,3-b]pyridine;

5-(3-fluoro-2-methoxy-4′

-(trifluoromethyl)41 ,t-biphenyl]-4-yl)pyrazin-2-amine;

5-(2′

,3,4′

-Trifluorobiphenyl-4-yl]pyrazin-2-amine;

(racemic) 5-[3-Fluoro-2′

-(methylsulfinyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-carbonitrile;

1 -(4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro41 , 1 ‘

-biphenyl]-2-yl)imidazolidin-2-one;

4’

-(2-Amino-4-cyanopyrimidin-5-yl)-N-tert-butyl-3′

-fluorobiphenyl-2-sulfonamide;

6-Amino-3-{2′

-[(1 , 1 -dioxidothiomorpholin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yllpyrazine-2-carbonitrile;

1 -{[4′

-(2-Aminopyrimidin-5-0-3′

-fluorobiphenyl-2-yl]sulfonyl}-N-methylazetidine-3-carboxamide;

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-sulfonamide;

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2S)-2-hydroxypropyl]biphenyl-2-sulfonamide;

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(2R)-2-hydroxypropyl]biphenyl-2-sulfonamide;

1-((4′

-(2-Aminopyrim idin-5-yl)-3′

-fluoro41 , 1 Lbiphenyl]-2-yl)sulfonyl)piperidine-4-carboxamide;

4′

-(5-Amino-3-cyanopyrazin-2-yI)-3′

-fluoro-N-[(1R)-2-hydroxy-1 -methylethyl]biphenyl-2-sulfonamide;

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-[(1S)-2-hydroxy-1-methylethyl]biphenyl-2-sulfonamide;

4′

-(5-Amino-3-cyanopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)-4-(trifluoromethyl)biphenyl-2-sulfonamide;

4′

-(5-Amino-3-cyanopyrazin-2-yl)-N-ethyl-3′

-fluoro-4-(trifluoromethyl)41 , 1‘

-biphenyl]-2-sulfonamide;

4’

-(5-Amino-3-cyanopyrazin-2-yI)-3′

-fluoro-N-(3-hydroxy-2,2-dimethylpropyl)biphenyl-2-sulfonamide;

6-Amino-3-{3-fluoro-2′

-[(3-oxopiperazin-1 -yl)sulfonyI]-4′

-(trifluoromethyl)biphenyl-4-yl}pyrazine-2-carbonitrile;

N-(2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyllethyl)benzamide;

b 1-{[4′

-(2-Aminopyrimidin-5-0-3′

-fluorobiphenyl-2-yl]sulfonyl1-3,3-dimethylbutan-2-one;

5-[3-Fluoro-2′

-(pyrimidin-2-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

5-[3-Fluoro-2′

-(pyrazin-2-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

5-[3-Fluoro-2′

-(pyrimidin-4-ylsulfonyl)biphenyl-4-yl]pyrimidin-2-amine;

5-{2′

-[(6-Aminopyrimidin-4-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(4-Aminopyrimidin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

5-{2′

-[(5-Aminopyrazin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-2-amine;

5-{2′

-[(6-Aminopyrazin-2-yl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

6-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-4-amine;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrimidin-4-amine;

5-{2′

-[(Cyclopropylmethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

6-Amino-342′

-(cyclopropylsulfonyl)-3-fluorobiphenyl-4-yl]pyrazine-2-carbonitrile;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarbonitrile;

1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarboxamide;

2-{[4′

-(2-Aminopyrimidin-5-0-3′

-fluorobiphenyl-2-yl]sulfonyl}2-methylpropanenitrile;

2-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanamide;

5-{2′

-[(2-Amino-1,1-dimethylethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

2-{[4′

-(5-Aminopyrazin-2-0-3′

-fluorobiphenyl-2-yl]sulfonyl1-2-methylpropanenitrile;

2-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-2-methylpropanamide;

5-{2′

-[(2-Amino-1,1-dimethylethyl)sulfonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarbonitrile;

1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}cyclopentanecarboxamide;

5-(2′

-{[1-(Aminomethyl)cyclopentyl]sulfonyl1-3-fluorobiphenyl-4-yl)pyrimidin-2-amine;

5-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]sulfanyl}pyrazin-2-amine;

5-{2′

-[(6-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-(3-Fluoro-2′

-(pyrimidin-4-ylthio)-[1,1′

-biphenyl]-4-yl)pyrazin-2-amine;

5-{2′

-[(5-Aminopyrazin-2-yl)sulfanyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine;

6-Amino-3-{2′

-[(4-aminopyrimidin-2-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazine-2-carbonitrile;

6-Amino-3-[3-fluoro-2′

-(pyrimidin-2-yloxy)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazine-2-carbonitrile;

6-Amino-3′

-fluoro-2′

-(pyrimidin-2-yloxy)biphenyl-4-yl]pyrazine-2-carbonitrile;

N-(tert-Butyl)-3′

-fluoro-4′

-(5-(methylsulfonamido)pyrazin-2-yl)41,1′

-biphenyl]-2-sulfonamide;

5-{2′

-[(Ethylsulfonyl)methyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{3-Fluoro-2′

-[(methylsulfonyl)methypiphenyl-4-yl}pyrazin-2-amine;

5-(3-Fluoro-2′

-{[(1-methylethyl)sulfonyl]methyllbiphenyl-4-yl)pyrazin-2-amine;

5-{3-Fluoro-2′

-[(pyrimidin-2-ylsulfonyl)methypiphenyl-4-yl}pyrazin-2-amine;

2-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]methyl}sulfanyl)pyrimidin-4-amine;

(racemic) 5-(3-Fluoro-2′

-{[2-(trifluoromethyl)morpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine;

1 -{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}azetidin-3-ol;

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(tetrahydro-2H-pyran-4-yl)biphenyl-2-carboxamide;

5-{2′

-[(1,1 -Dioxidothiomorpholin-4-yl)carbonyl]-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yllpyrazin-2-amine;

1 -(4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}morpholin-2-ypethanol (diastereomeric mixture);

1 -(4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}morpholin-2-yl)ethanol (diastereomeric mixture);

4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-carboxamide;

4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(2-hydroxyethyl)biphenyl-2-carboxamide;

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol;

(cis/trans) 4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl)biphenyl-2-carboxamide;

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol;

(cis/trans) 4′

-(2-Aminopyrimidin-5-yl)-3′

-fluoro-N-(4-hydroxycyclohexyl}biphenyl-2-carboxamide;

(racemic) 5-(3-Fluoro-2′

-{[2-(trifluoromethyl)morpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine;

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol;

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}piperidin-3-ol;

(3R)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol;

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol;

(3S)-1-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol;

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]carbonyl}pyrrolidin-3-ol;

5-{2′

-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine (diastereoisomeric mixture);

5-(3-Fluoro-2′

-{[(3S)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine;

5-(3-Fluoro-2′

-{[(3R)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrazin-2-amine;

5-(3-Fluoro-2′

-{[(2S)-2-methylmorpholin-4-yl]carbonyl}piphenyl-4-yl)pyrazin-2-amine;

5-(3-Fluoro-2′

-{[(2S)-2-methylmorpholin-4-yl]carbonyl}piphenyl-4-yl)pyrimidin-2-amine;

5-(3-Fluoro-2′

-{[(3S)-3-methylmorpholin-4-yl]carbonyl}piphenyl-4-yl)pyrimidin-2-amine;

5-(3-Fluoro-2′

-{[(3R)-3-methylmorpholin-4-yl]carbonyl}biphenyl-4-yl)pyrimidin-2-amine;

5-{2′

-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-3-fluorobiphenyl-4-yl}pyrimidin-2-amine (diastereoisomeric mixture);

5-{2-Fluoro-4-[2-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}-1H-pyrrolo[2,3-1D]pyridine;

5-{2-Fluoro-442-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine;

5-{2-Fluoro-442-(morpholin-4-ylcarbonyl)pyridin-3-yl]phenyl}pyrazin-2-amine;

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-N-tert-butyl-5-(trifluoromethyl)benzamide;

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-N-[(1R)-2-hydroxy-1-methyl-ethyl]-5-(trifluoromethyl)benzamide;

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-N-[(1S)-2-hydroxy-1-methyl-ethyl]-5-(trifluoromethyl)benzamide;

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1 R)-2,2,2-trifluoro-1-methyl-ethyl]benzamide;

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1 S)-2,2,2-trifluoro-1-methyl-ethyl]benzamide;

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1 R)-2,2,2-trifluoro-1-methyl-ethyl]benzamide;

2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)-N-[(1 S)-2,2,2-trifluoro-1-methyl-ethyl]benzamide;

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]phenyl]-(3-hydroxyazetidin-1 -yl)methanone;

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]phenylH4-(methylamino)-1-piperidyl]methanone;

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)phenyl]-(1 ,1-dioxo-1 ,4-thiazinan-4-yl)methanone;

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-N-tert-butyl-5-(trifluoromethyl)benzamide;

[2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)phenyl]-(4-hydroxy-1 -piperidyl)methanone;

[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-5-(trifluoromethyl)phenyl]-(4-hydroxy-1-piperidyl)methanone;

2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]-N-tetrahydropyran-4-yl-benzam ide;

(racemic) [2-[4-(5-Aminopyrazin-2-yl)-3-fluoro-phenyl]phenyl-2-(hydroxymethyl)morpholin-4-yl]methanone;

(racemic)[2-[4-(2-Aminopyrimidin-5-yl)-3-fluoro-phenyl]phenyl]-[2-(hydroxymethyl)morpholin-4-yl]methanone;

N-{3-[4-(2-Aminopyrimidin-5-0-3-fluorophenyl]pyridin-2-}-2,2-dimethylpropanamide;

N-{3-[4-(5-Aminopyrazin-2-0-3-fluorophenyl]pyridin-2-}-2,2-dimethylpropanamide;

N-{3-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]pyridin-2yl}-2,2-dimethylpropanamide;

(racemic) 5-(2-Fluoro-4-(2-(pyrrolidin-3-ylsulfonyl)pyridin-3-yl)phenyl)pyrazin-2-amine;

5-(2-Fluoro-4-(2-(pyrrolidin-3-ylsulfonyl)pyridin-3-yl)phenyl)pyrimidin-2-amine;

5-(4-(2-(Cyclobutylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine;

5-(4-(2-(Cyclobutylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine;

5-(4-(2-(CyclohexIsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine;

5-(4-(2-(Cyclohexylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine;

5-(4-(2-(Cyclopentylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidine-2-amine;

5-(4-(2-(Cyclopentylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine;

5-(4-(2-(tert-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine;

5-(4-(2-(tert-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine;

(racemic) 5-(4-(2-(sec-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrimidin-2-amine;

(racemic)5-(4-(2-(sec-Butylsulfonyl)pyridin-3-yl)-2-fluorophenyl)pyrazin-2-amine;

1-((3-(4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)piperidin-1-yl)ethanone;

1-((3-(4-(2-Aminopyrazin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)piperidin-1-yl)ethanone;

5-(2-Fluoro-4-(2-((3-methoxypropyl)sulfonyl)pyridine-3-yl)phenyl)pyrimidin-2-amine;

5-(2-Fluoro-4-(2-((3-methoxypropyl)sulfonyl)pyridine-3-yl)phenyl)pyrazin-2-amine;

4-((3-(4-(2-Aminopyrimidin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)tetrahydro-2H-thiopyran 1,1-dioxide;

4-((3-(4-(2-Aminopyrazin-5-yl)-3-fluorophenyl)pyridine-2-yl)sulfonyl)tetrahydro-2H-thiopyran 1,1-dioxide;

5-(2-Fluoro-4-(2-((2-morpholinoethyl)sulfonyl)pyridine-3-yl)phenyl)pyrimidin-2-amine;

5-(2-Fluoro-4-(2-((2-morpholinoethyl)sulfonyl)pyridine-3-yl)phenyl)pyrazin-2-amine;

5-(2-Fluoro-4-(2-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)pyridine-3-yl)pyrimidin-2-amine;

5-(2-Fluoro-4-(2-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)pyridine-3-yl)pyrazin-2-amine;

5-(2-Fluoro-4-{2-[(1 -methylethyl)sulfonyl]pyridin-3-yllphenyl)pyrimidin-2-amine;

5-(2-Fluoro-4-(2-(isopropylsulfonyl)pyridine-3-yl)phenyl)-1 H-pyrrolo[2,3-b]pyridine;

5-{2-Fluoro-442-(piperidin-4-ylsulfonyl)pyridin-3-yl]phenyllpyrimidin-2-amine;

5-{4-[2-(Cyclopropylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrimidin-2-amine;

5-{4-[2-(Cyclopropylsulfonyl)pyridin-3-yl]-2-fluorophenyl}pyrazin-2-amine;

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine;

5-{2-Fluoro-4-[2-(piperidin-4-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-(2,3-Difluorobiphenyl-4-yl)pyrazin-2-amine;

5-(3-Fluoro-2-methoxybiphenyl-4-yl)pyrazin-2-amine;

5-[3-Fluoro-2-methoxy-2′

-(methylsulfonyl)biphenyl-4-yl]pyrazin-2-amine;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-2′

-methoxybiphenyl-2-sulfonamide;

N-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-2′

-methoxybiphenyl-2-yl]methanesulfonamide;

5-(3-Fluoro-2′

-(pyrazin-2-yl)41 ,t-biphenyl]-4-yl)pyrazin-2-amine;

5-(3-Fluoro-2′

-pyrazin-2-ylbiphenyl-4-yl)pyrimidin-2-amine;

5,5′

-(3′

-Fluorobiphenyl-2,4′

-diyl)dipyrazin-2-amine;

5-[2′

-(5-Aminopyrazin-2-yl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine;

5-[2′

-(6-Aminopyrazin-2-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrimidin-2-amine;

5,5′

-(3′

-Fluorobiphenyl-2,4′

-diyl)dipyrimidin-2-amine;

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-5-(trifluoromethyl)biphenyl-2-yl]pyrimidin-2-amine;

5-[3-Fluoro-2′

-(2-methoxypyrimidin-5-yl)biphenyl-4-yl]pyrazin-2-amine;

5-[3-Fluoro-2′

-(1-methyl-1 H-pyrazol-4-yl)biphenyl-4-yl]pyrazin-2-amine;

5-(3-Fluoro-2′

-pyrimidin-5-ylbiphenyl-4-yl)pyrazin-2-amine;

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrimidine-2-carbonitrile;

5-[3-Fluoro-2′

-(2-morpholin-4-ylpyrimidin-5-yl)biphenyl-4-yl]pyrazin-2-amine;

1-{4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1 H-pyrazol-l-yl}-2-methylpropan-2-ol;

5-[3-Fluoro-2′

-(1,2,3,6-tetrahydropyridin-4-yl)-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-yl]pyrimidin-2-amine;

5-{2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]phenyl}pyrimidin-2-amine;

5-{5-[2-(2-Aminopyrimidin-5-yl)phenyl]pyridin-2-yl}pyrimidin-2-amine;

5-[2′

41 ,1-Dioxidoisothiazolidin-2-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5-[2′

41 ,1-Dioxido-1 ,2-thiazinan-2-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5-[2′

41 ,1-Dioxidoisothiazolidin-2-yl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine;

5-[2-Fluoro-4-(2-pyrrolidin-1-ylpyridin-3-yl)phenyl]pyrazin-2-amine;

1-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrrolidin-2-one;

(2S)-2-({344-(2-Aminopyrimidin-5-yl)-3-fluorophenyl]pyridin-2-ylloxy)propan-1-ol;

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3-carboxamide;

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3-carboxamide;

5-{3-Fluoro-2′

-[(1 S,4S)-2-oxa-5-azabicyclo[2.2.1 ]hept-5-ylsulfonyl]biphenyl-4-yl}pyrazin-2-amine;

4′

-(6-Amino-5-fluoropyridin-3-yl)-3′

-fluoro-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylbiphenyl-2-sulfonamide;

4′

-(6-Aminopyridin-3-yl)-3′

-fluoro-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylbiphenyl-2-sulfonamide;

4′

-(6-Aminopyridazin-3-yl)-3′

-fluorobiphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-5-(trifluoromethyl)biphenyl-2-sulfonamide;

N4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]methanesulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-5-methoxybiphenyl-2-sulfonamide;

(3S)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3-carboxamide;

(3R)-1-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}pyrrolidine-3-carboxamide;

5-[3-Fluoro-2′

-(morpholin-4-ylcarbonyl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[(Cyclopropylmethyl)sulfonyl]-3-fluorobiphenyl-4-yllpyrazin-2-amine;

1-{[4′

-(2-Am inopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]sulfonyl}-4-(pentafluoroethyl)piperidin-4-ol;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

-fluoro-4-(trifluoromethyl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3′

,4-difluorobiphenyl-2-sulfonamide;

2-[3-Fluoro-2′

-(methylsulfanyl)biphenyl-4-yl]-5H-pyrrolo[2, 3-b]pyrazine;

N,N-Diethyl-3′

-fluoro-4′

-(1H-pyrrolo[2,3-b]pyridin-5-yl)biphenyl-2-sulfonamide;

4′

-(5-Aminopyrazin-2-yl)-N-tert-butyl-3, 3′

-difluorobiphenyl-2-sulfonamide;

5-2′

-Amino-3-fluoro-4′

-(trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2′

-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

4-({[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxylmethyl)benzoic acid;

4-({[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxylmethyl)benzoic acid;

4-{[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]oxy}benzoic acid;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxy}benzoic acid;

2-[4-({3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}sulfonyl)piperidin-1-yl]ethanol;

4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyrimidin-2-amine;

1-[4{3-[4-(5-Aminopyrazin-2-yl)-3-fluorophenyl]pyridin-2-yl}sulfonyl)pipendin-1 -yl]propan-2-ol;

5-[3-Fluoro-2′

-(1 H-pyrazol-4-yl)biphenyl-4-yl]pyrazin-2-amine;

5-[2′

-(6-Aminopyridin-3-yl)-3-fluorobiphenyl-4-yl]pyrazin-2-amine;

5-{3-Fluoro-2′

41-(2-methoxyethyl)-1 H-pyrazol-4-yl]biphenyl-4-yl}pyrazin-2-amine;

5-{5-[2-(Cyclopropylsulfonyl)phenyl]-3-fluoropyridin-2-yl}pyrimidin-2-amine;

4-{[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]oxylbenzamide;

5-{2′

-[(trans-4-Aminocyclohexyl)oxy]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

5-{2-Fluoro-4-[2-(phenylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine;

6-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]pyridazin-3-amine;

{4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1H-pyrazol-1 -yl}acetonitrile;

5-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-N-methylpyrimidin-2-amine;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzenesulfonamide;

5-{2-Fluoro-4-[2-(phenylsulfonyl)pyridin-3-yl]phenyl}pyrimidin-2-amine;

5-[3-Fluoro-2′

-(2-piperazin-1-ylpyrimidin-5-yl)biphenyl-4-yl]pyrazin-2-amine;

5-{2′

-[1-(2-Aminoethyl)-1H-pyrazol-4-yl]-3-fluorobiphenyl-4-yl}pyrazin-2-amine;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(2S)-2-hydroxypropyl]benzenesulfonamide;

5-(3-Fluoro-2′

-isothiazol-4-ylbiphenyl-4-yl)pyrazin-2-amine;

5-[2-Fluoro-4-(2-phenoxypyridin-3-yl)phenyl]pyrazin-2-amine;

5-[2-Fluoro-4-(2-phenoxypyridin-3-yl)phenyl]pyrimidin-2-amine;

2-{4-[4′

-(5-Aminopyrazin-2-yl)-3′

-fluorobiphenyl-2-yl]-1H-pyrazol-1-yl}ethanol;

5-(4-{2-[(1 -Acetylpipendin-3-yl)sulfonyl]pyridin-3-yl1-2-fluorophenyl)pyrazin-2-amine;

5-(4-{2-[(1 -Acetylpipendin-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-yl1-2-fluorophenyl)pyrazin-2-amine;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1S)-2-hydroxy-1-methylethyl]benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]benzenesulfonamide;

5-[2-Fluoro-4-(2-phenyl]pyridin-3-yl)phenyl]pyrazin-2-amine;

5-(2-Fluoro-4-{2-[(1 -methylpyrrolidin-3-yl)sulfonyl]pyridin-3-yl}phenyl)pyrazin-2-amine;

5-{2-Fluoro-4-[2-(pyridin-3-ylsulfonyl)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-(2-Fluoro-4-{2-[(1 -methylethyl)sulfonyI]-6-(trifluoromethyl)pyridin-3-yl}phenyl)pyrazin-2-amine;

5-(4-{2-[(1 -Acetylpiperidin-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-01-2-fluorophenyl)pyrimidin-2-amine;

5-[2′

-(6-Aminopyridin-3-yl)-3-fluorobiphenyl-4-yl]pyrimidin-2-amine;

5-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]-N-methylpyrimidin-2-amine;

5-(2-Fluoro-4-{2-[(1 -methylethyl)sulfonyI]-6-(trifluoromethyl)pyridin-3-yl}phenyl)pyrimidin-2-amine;

{4-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]-1 H-pyrazol-1 -yl}acetonitrile;

5-[3-Fluoro-2′

-(1 H-pyrazol-4-yl)biphenyl-4-yl]pyrimidin-2-amine;

4-[4′

-(2-Aminopyrimidin-5-yl)-3′

-fluorobiphenyl-2-yl]pyrim din-2-amine;

5-{2-Fluoro-4-[2-(pyridin-3-yloxy)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-(4-{2-[(1 ,1 -Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-01-2-fluorophenyl)pyrimidin-2-amine;

5-[2-Fluoro-4-(2-{[1 -(methylsulfonyl)piperidin-4-yl]sulfonyl}pyridin-3-yl)phenyl]pyrazin-2-amine;

5-(4-{2-[(1 ,1 -Dioxidotetrahydro-2H-thiopyran-4-yl)sulfonyl]-6-(trifluoromethyl)pyridin-3-01-2-fluorophenyl)pyrazin-2-amine;

5-{2-Fluoro-4-[2-(tetrahydro-2H-pyran-4-ylsulfonyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}pyrazin-2-amine;

5-{2-Fluoro-4-2-(tetrahydro-2H-pyran-4-ylsulfonyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}pyrimidin-2-amine;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-(2-hydroxyethyl)benzenesulfonamide;

2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1 R)-2,2,2-trifluoro-1 -methylethyl]benzenesulfonamide; and

5-[2-Fluoro-4-(2-{[1-(methylsulfonyl)piperidin-4-yl]sulfonyllpyridin-3-yl)phenyl]pyrimidin-2-amine;

and pharmaceutically acceptable salts thereof.