Anti-ανβ6 antibodies
First Claim
Patent Images
1. A DNA encoding a heavy chain of an anti-α
- vβ
6 antibody or antigen-binding fragment thereof, the humanized heavy chain comprising a heavy chain variable region comprising complementarity determining regions (CDRs) 1, 2, and 3 consisting of the amino acid sequences set forth in SEQ ID NOs.;
3, 6, and 9, respectively.
3 Assignments
0 Petitions
Accused Products
Abstract
Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.
73 Citations
8 Claims
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1. A DNA encoding a heavy chain of an anti-α
- vβ
6 antibody or antigen-binding fragment thereof, the humanized heavy chain comprising a heavy chain variable region comprising complementarity determining regions (CDRs) 1, 2, and 3 consisting of the amino acid sequences set forth in SEQ ID NOs.;
3, 6, and 9, respectively.
- vβ
-
2. A DNA encoding a light chain of an anti-α
- vβ
6 antibody or antigen-binding fragment thereof, the light chain comprising a light chain variable region comprising complementarity determining regions (CDRs) 1, 2, and 3 consisting of the amino acid sequences set forth in SEQ ID NOs.;
12, 14, and 18, respectively.
- vβ
-
3. A host cell producing an anti-α
- vβ
6 antibody or antigen-binding fragment thereof, comprising;a first DNA encoding a heavy chain of the anti-α
vβ
6 antibody or antigen-binding fragment thereof, the heavy chain comprising a heavy chain variable region comprising complementarity determining regions (CDRs) 1, 2, and 3 consisting of the amino acid sequences set forth in SEQ ID NOs.;
3, 6, and 9, respectively; anda second DNA encoding a light chain of the anti-α
vβ
6 antibody or antigen-binding fragment thereof, the light chain comprising a light chain variable region comprising CDRs 1, 2, and 3 consisting of the amino acid sequences set forth in SEQ ID NOs.;
12, 14, and 18, respectively. - View Dependent Claims (4, 5, 6, 7, 8)
- vβ
Specification