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Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4

  • US 9,745,584 B2
  • Filed: 02/10/2015
  • Issued: 08/29/2017
  • Est. Priority Date: 05/14/2010
  • Status: Active Grant
First Claim
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1. A synthetic, modified oligonucleotide of 15 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from:

  • at least one modified sugar moiety;

    at least one modified internucleotide linkage;

    at least one modified nucleotide, and combinations thereof;

    wherein said oligonucleotide is an antisense compound which is 100% complementary to and specifically hybridizes to a complementary region of a natural antisense polynucleotide of a PAR4 gene wherein said natural antisense comprises SEQ ID NO;

    2 and upregulates the function and/or expression of a PAR4 gene in vivo or in vitro as compared to a normal control.

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