Switched-capacitor biosensor device
First Claim
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1. An apparatus comprising:
- an electrically insulating layer;
a crystalline semiconductor layer adjoining a first side of the electrically insulating layer;
a handle substrate adjoining a second side of the electrically insulating layer;
one or more switched capacitor circuits, each of the one or more switched capacitor circuits including metal oxide semiconductor field effect transistors on the crystalline semiconductor layer, each of the transistors including source and drain regions;
a plurality of capacitor structures extending perpendicularly with respect to the crystalline semiconductor layer, each of the plurality of capacitor structures being electrically connected to a pair of the transistors, anda plurality of microwells extending within the handle substrate, the plurality of capacitor structures extending within the plurality of microwells, the plurality of capacitor structures and the plurality of microwells being configured such that the one or more switched capacitor circuits are responsive to changes in ion concentration within one or more of the plurality of microwells.
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Abstract
A sensing apparatus includes a device containing microwells and a switched capacitor circuit in which at least one of the sensing/storage capacitors is a capacitor that extends perpendicularly with respect to a semiconductor device layer containing field effect transistors. Capacitor structures extend into microwells or within a doped layer on a handle substrate. Ion generation within the microwells is sensed using the circuit.
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Citations
15 Claims
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1. An apparatus comprising:
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an electrically insulating layer; a crystalline semiconductor layer adjoining a first side of the electrically insulating layer; a handle substrate adjoining a second side of the electrically insulating layer; one or more switched capacitor circuits, each of the one or more switched capacitor circuits including metal oxide semiconductor field effect transistors on the crystalline semiconductor layer, each of the transistors including source and drain regions; a plurality of capacitor structures extending perpendicularly with respect to the crystalline semiconductor layer, each of the plurality of capacitor structures being electrically connected to a pair of the transistors, and a plurality of microwells extending within the handle substrate, the plurality of capacitor structures extending within the plurality of microwells, the plurality of capacitor structures and the plurality of microwells being configured such that the one or more switched capacitor circuits are responsive to changes in ion concentration within one or more of the plurality of microwells. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method comprising:
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obtaining an apparatus including; an electrically insulating layer, a crystalline semiconductor layer adjoining a first side of the electrically insulating layer, a handle substrate adjoining a second side of the electrically insulating layer; one or more switched capacitor circuits, each of the one or more switched capacitor circuits including metal oxide semiconductor field effect transistors on the crystalline semiconductor layer, each of the transistors including source and drain regions; a plurality of capacitor structures extending perpendicularly with respect to the crystalline semiconductor layer, each of the plurality of capacitor structures being electrically connected to a pair of the transistors, and a plurality of microwells extending within the handle substrate, the plurality of capacitor structures extending within the plurality of microwells, the plurality of capacitor structures and the plurality of microwells being configured such that the one or more switched capacitor circuits are responsive to changes in ion concentration within one or more of the plurality of microwells; introducing one or more fluids into the plurality of microwells, and detecting a change in ion concentration in the one or more fluids within the plurality of microwells using the one or more switched capacitor circuits. - View Dependent Claims (8, 9, 10)
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11. An apparatus comprising:
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an electrically insulating layer; a crystalline semiconductor layer adjoining a first side of the electrically insulating layer; a doped semiconductor layer adjoining a second side of the electrically insulating layer; one or more switched capacitor circuits, each of the one or more switched capacitor circuits including metal oxide semiconductor field effect transistors on the crystalline semiconductor layer, each of the transistors including source and drain regions; a plurality of capacitor structures extending perpendicularly with respect to the crystalline semiconductor layer, each of the plurality of capacitor structures including a doped, electrically conductive core and a dielectric coating over the core, each of the plurality of capacitor structures extending into the doped semiconductor layer such that the dielectric coating directly contacts the doped semiconductor layer, each of the plurality of capacitor structures being electrically connected to a pair of the transistors; a plurality of microwells, the plurality of capacitor structures and the plurality of microwells being configured such that the one or more switched capacitor circuits are responsive to changes in ion concentration within one or more of the plurality of microwells, and electrical contacts respectively adjoining each of the plurality of microwells, each of the electrical contacts being electrically connected to the source region of one of the transistors. - View Dependent Claims (12, 13, 14, 15)
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Specification