Pressure-sensing intravascular devices, systems, and methods

• US 9,750,418 B2
• Filed: 12/18/2013
• Issued: 09/05/2017
• Est. Priority Date: 12/21/2012
• Status: Active Grant

• Current Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Original Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Inventors: Millett, Bret C., Burkett, David H., Corl, Paul Douglas
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): Alter, Mitchell E
• Application Number:
  US14/133,348
• Publication Number:
  US 20140180142A1
• Time in Patent Office: 1,357 Days
• Field of Search: 600488, 29825
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/6851 Guide wires
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing

Abstract

Intravascular devices, systems, and methods are disclosed. In some embodiments, the intravascular devices include at least one pressure sensing component within a distal portion of the device. In that regard, one or more electrical, electronic, optical, and/or electro-optical pressure-sensing components is secured to an elongated substrate such that the pressure-sensing component is mounted perpendicular to a central longitudinal axis of the device. In some implementations, the elongated substrate has a cylindrical profile. Methods of making, assembling, and/or using such intravascular devices and associated systems are also provided.

Claims

1. An intravascular sensor assembly comprising:

a flexible elongate member;

a core member disposed inside the flexible elongate member;

an electrical conductor extending along the core member; and

an elongated substrate disposed distal to the core member and inside the flexible elongate member, the elongated substrate comprising;

a plurality of electrodes disposed within the elongated substrate and extending through the elongated substrate in a longitudinal direction, the plurality of electrodes being uniformly distributed around a longitudinal axis (LA) of the elongated substrate, wherein the electrical conductor is coupled to at least one electrode; and

a sensor circuit disposed on a distal surface of the elongated substrate, the sensor circuit coupled to at least one electrode, wherein the sensor circuit comprises an intravascular pressure sensor circuit.

2. The intravascular sensor assembly of claim 1 wherein the plurality of electrodes comprises three electrodes configured to be coupled to three different terminals of the sensor circuit.

3. The intravascular sensor assembly of claim 1 wherein the flexible elongate member comprises at least one through hole at a distal end so as to expose the sensor circuit to an intravascular ambient.

4. The intravascular sensor assembly of claim 1 wherein the elongated substrate has a substantially cylindrical shape with the cylindrical axis along the LA.

5. The intravascular sensor assembly of claim 1 wherein the elongated substrate is made of a material selected from the group consisting of silicon, germanium, a silicon-germanium alloy, silica, quartz, sapphire, a ceramic material, a plastic material, and a combination thereof.

6. The intravascular sensor assembly of claim 1 further comprising a cable along the core member between a proximal portion and a distal portion of the flexible elongate member, the cable including the electrical conductor, wherein the electrical conductor is electrically coupled to the at least one electrode on a proximal surface of the elongated substrate.

7. The intravascular sensor assembly of claim 1 wherein the sensor circuit comprises a micro-electromechanical system (MEMS).

8. The intravascular sensor assembly of claim 1 wherein the elongated substrate is bonded to the core member using an adhesive selected from the group consisting of urethane acrylate, cyanoacrylate, silicone, epoxy, and any combination thereof.

9. A sensor structure for use in an intravascular device assembly, the sensor structure comprising:

a substrate comprising an elongated shape with a length defined along a longitudinal axis (LA) and a width extending perpendicular to the longitudinal axis, the shape further comprising;

a proximal surface and an opposing distal surface, each extending substantially perpendicular to the LA; and

an outer surface extending substantially parallel to the LA;

a plurality of electrodes disposed within the substrate and extending longitudinally through the substrate, the plurality of electrodes being uniformly distributed around the LA, wherein at least one electrode is coupled to an electrical conductor of the intravascular device assembly; and

a sensor circuit disposed on the distal surface, the sensor circuit comprising at least one lead coupled to at least one electrode, wherein the sensor circuit comprises an intravascular pressure sensor circuit.

10. The sensor structure of claim 9 wherein the substrate is made of a material selected from the group consisting of silicon, germanium, a silicon-germanium alloy, quartz, glass, sapphire, a ceramic material, a plastic material, or a combination thereof.

11. The sensor structure of claim 9 wherein at least one electrode extends from the distal surface to the proximal surface.

12. The sensor structure of claim 9 wherein at least one electrode extends from the distal surface towards the proximal surface such that a proximal end of the electrode is spaced distally from the proximal surface.

13. The sensor structure of claim 9 wherein the sensor circuit is bonded to the distal surface in a flip chip configuration.

14. A system for performing measurements using a sensor exposed to an intravascular environment, the system comprising:

an intravascular device comprising;

a flexible elongate member;

a core member disposed inside the flexible elongate member;

an electrical conductor extending along the core member; and

an elongated substrate disposed distal to the core member and inside the flexible elongate member, the elongated substrate comprising;

a plurality of electrodes disposed within the elongated substrate and extending through the elongated substrate in a longitudinal direction, the plurality of electrodes uniformly distributed around a longitudinal axis (LA) of the elongated substrate, wherein the electrical conductor is coupled to at least one electrode; and

a sensor circuit disposed on a distal surface of the elongated substrate, the sensor circuit coupled to at least one electrode, wherein the sensor circuit comprises an intravascular pressure sensor circuit; and

a control console coupled to the intravascular device.

15. The system of claim 14 further comprising an interface device positioned between the control console and the intravascular device, wherein the interface device provides power to the sensor circuit and processes a signal from the sensor circuit.

16. The system of claim 15 wherein the interface device comprises an analog to digital converting circuit to provide a digital signal to the console.

17. The system of claim 14 wherein the control console outputs a graph of a blood pressure along a longitudinal axis in the intravascular environment.

18. The system of claim 14 wherein the elongated substrate has a substantially cylindrical shape with the cylindrical axis along the LA.

19. The system of claim 18 wherein the elongated substrate is bonded to the core member using an adhesive.