Methods of intravenous drug monitoring
First Claim
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1. A non-invasive method of monitoring an anesthetic drug concentration in plasma of a patient using the patient'"'"'s breath, comprising:
- (a) administering an anesthetic drug to the patient using an infusion pump;
(b) collecting a breath sample using a breathing circuit connected to the patient, wherein the breath sample comprises a mixed gas comprising a combination of end-tidal gas, gas from dead-space, and inspiratory gas;
(c) exposing a system comprising a detector, a processor, and one or more sensors to the breath sample;
(d) detecting one or more components of the anesthetic drug in the breath sample using the detector;
(e) measuring a concentration of at least one of the one or more components of the anesthetic drug in the breath sample using the one or more sensors;
(f) measuring one or more parameters of the patient using the one or more sensors; and
(g) determining an anesthetic drug concentration in plasma of the patient based on the measured concentration of the at least one of the one or more components of the anesthetic drug in the breath sample and the one or more parameters of the patient using the processor, wherein the processor is configured to calculate the anesthetic drug concentration using a transfer function, and wherein the anesthetic drug concentration is a concentration of the one or more components of the anesthetic drug in the plasma of the patient;
wherein the transfer function comprises an input value and an output value, wherein the transfer function comprises a non-linear equation that uses a second order or a higher order, and wherein the input value of the transfer function at least depends on a temperature parameter of the one or more parameters to normalize the measured concentration in the breath sample;
(h) providing a target range of the anesthetic drug concentration;
(i) comparing the anesthetic drug concentration with the target range;
(j) if the anesthetic drug concentration is outside the target range;
(1) generating an alarm;
(2) adjusting an anesthetic drug dosage to the patient;
(3) delivering the anesthetic drug to the patient;
or(k) if the anesthetic drug concentration is within the target range;
(1) delivering the anesthetic drug to the patient; and
(l) repeating steps (b) through (k) as needed until procedure is completed.
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Abstract
A method of monitoring a concentration of an anesthetic drug using a patient'"'"'s breath is provided. The method comprises forming a breath sample using the patient'"'"'s breath; exposing one or more sensors to the breath sample; detecting one or more components of the anesthetic drug in the breath sample; measuring a concentration of at least one of the components of the anesthetic drug in the breath sample; and determining a concentration of the component in a plasma of the patient using a transfer function and the concentration of the component in the breath sample.
9 Citations
16 Claims
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1. A non-invasive method of monitoring an anesthetic drug concentration in plasma of a patient using the patient'"'"'s breath, comprising:
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(a) administering an anesthetic drug to the patient using an infusion pump; (b) collecting a breath sample using a breathing circuit connected to the patient, wherein the breath sample comprises a mixed gas comprising a combination of end-tidal gas, gas from dead-space, and inspiratory gas; (c) exposing a system comprising a detector, a processor, and one or more sensors to the breath sample; (d) detecting one or more components of the anesthetic drug in the breath sample using the detector; (e) measuring a concentration of at least one of the one or more components of the anesthetic drug in the breath sample using the one or more sensors; (f) measuring one or more parameters of the patient using the one or more sensors; and (g) determining an anesthetic drug concentration in plasma of the patient based on the measured concentration of the at least one of the one or more components of the anesthetic drug in the breath sample and the one or more parameters of the patient using the processor, wherein the processor is configured to calculate the anesthetic drug concentration using a transfer function, and wherein the anesthetic drug concentration is a concentration of the one or more components of the anesthetic drug in the plasma of the patient;
wherein the transfer function comprises an input value and an output value, wherein the transfer function comprises a non-linear equation that uses a second order or a higher order, and wherein the input value of the transfer function at least depends on a temperature parameter of the one or more parameters to normalize the measured concentration in the breath sample;(h) providing a target range of the anesthetic drug concentration; (i) comparing the anesthetic drug concentration with the target range; (j) if the anesthetic drug concentration is outside the target range; (1) generating an alarm; (2) adjusting an anesthetic drug dosage to the patient; (3) delivering the anesthetic drug to the patient;
or(k) if the anesthetic drug concentration is within the target range; (1) delivering the anesthetic drug to the patient; and (l) repeating steps (b) through (k) as needed until procedure is completed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A non-invasive method of monitoring a propofol concentration in a plasma of a patient, comprising:
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(a) administering an anesthetic drug comprising propofol to the patient using an infusion pump; (b) collecting a breath sample using a breathing circuit connected to the patient, wherein the breath sample comprises a mixed gas comprising a combination of end-tidal gas, gas from dead-space, and inspiratory gas; (c) exposing a system comprising a detector, a processor, and one or more sensors to the breath sample; (d) detecting propofol in the breath sample using the detector; (e) measuring a concentration of propofol in the breath sample using the one or more sensors; (f) measuring one or more parameters of the patient using the one or more sensors; and (g) determining a propofol concentration in plasma of the patient based on the measured concentration of propofol in the breath sample and the one or more parameters of the patient using the processor, wherein the processor is configured to calculate the propofol concentration using a transfer function and the concentration of the propofol in the breath sample, wherein the transfer function comprises an input value and an output value, and wherein the transfer function comprises a non-linear equation that uses a second order or higher order, and the input value of the transfer function at least depends on a temperature parameter of the one or more parameters to normalize the measured breath drug concentration; (h) providing a target range of propofol in the plasma of the patient; (i) comparing the propofol concentration with the target range; (j) if the propofol concentration is outside the target range; (1) generating an alarm; (2) adjusting a propofol dosage to the patient; (3) delivering the anesthetic drug comprising propofol to the patient;
or(k) if the propofol concentration is within the target range; (1) delivering the anesthetic drug comprising propofol to the patient; and (l) repeating steps (b) through (k) as needed until procedure is completed. - View Dependent Claims (12, 13, 14, 15, 16)
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Specification