Systems and methods for measurement of tissue perfusion
First Claim
1. A system that measures perfusion through a volume of tissue, the system comprising:
- a non-transitory memory to store computer-executable instructions; and
a processor that executes the computer-executable instructions to at least;
receive an ultrasound signal response of a contrast agent within a volume of tissue as a function of time, wherein the contrast agent is infused into a patient'"'"'s vasculature at a constant rate,wherein the volume of tissue comprises a and a geometry, wherein the geometry is a rectangular prism with a corresponding length, width, and height;
determine a probabilistic constant based on the geometry of the volume of tissue;
determine a ratio of mean velocity to mean path length based on the ultrasound signal response at a first time representing a transitory intensity and a second time corresponding to a steady state intensity;
determine a tissue density of the volume of tissue; and
determine a mean perfusion through the volume of tissue based on the probabilistic constant, the ratio of mean velocity to mean path length, the tissue density, the width, and the height.
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Accused Products
Abstract
One aspect of the present disclosure relates to a system that can measure profusion through a volume of tissue. The system can include a non-transitory memory that stores instructions and a processor that can be configured to execute the instructions to at least: receive an ultrasound signal response of a contrast agent within a volume of interest and determine the perfusion through the volume of tissue based on a probabilistic constant related to the geometry, the tissue density, the ultrasound signal response, and a feature of the geometry. The ultrasound signal response can include a time dimension and three position dimensions. The volume of interest can include a tissue density and a geometry.
5 Citations
12 Claims
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1. A system that measures perfusion through a volume of tissue, the system comprising:
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a non-transitory memory to store computer-executable instructions; and a processor that executes the computer-executable instructions to at least; receive an ultrasound signal response of a contrast agent within a volume of tissue as a function of time, wherein the contrast agent is infused into a patient'"'"'s vasculature at a constant rate, wherein the volume of tissue comprises a and a geometry, wherein the geometry is a rectangular prism with a corresponding length, width, and height; determine a probabilistic constant based on the geometry of the volume of tissue; determine a ratio of mean velocity to mean path length based on the ultrasound signal response at a first time representing a transitory intensity and a second time corresponding to a steady state intensity; determine a tissue density of the volume of tissue; and determine a mean perfusion through the volume of tissue based on the probabilistic constant, the ratio of mean velocity to mean path length, the tissue density, the width, and the height. - View Dependent Claims (2, 3, 4, 5)
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6. A method comprising the steps of:
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receiving, by a system comprising a processor, an ultrasound signal response of a contrast agent within a volume of tissue as a function of time, wherein the contrast agent is infused into a patient'"'"'s vasculature at a constant rate, wherein the volume of tissue comprises a geometry, wherein the geometry is a rectangular prism with a corresponding length, width, and height; determining, by the system, a probabilistic constant based on the geometry of the volume of the tissue; determining, by the system, a ratio of mean velocity to mean path length based on the ultrasound signal response at a first time representing a transitory intensity and a second time representing a steady state intensity; determining, by the system, a tissue density of the volume of the tissue; and determining, by the system, a mean perfusion through the volume of tissue based on the probabilistic constant, the ratio of mean velocity to mean path length, the tissue density, the width, and the height. - View Dependent Claims (7, 8, 9)
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10. A non-transitory computer-readable medium having stored thereon instructions that, upon execution, cause a processor of one or more computing devices to perform operations, the operations comprising:
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receiving an ultrasound signal response of a contrast agent within a volume of tissue as a function of time, wherein the contrast agent is infused into a patient'"'"'s vasculature at a constant rate, wherein the volume of tissue comprises a geometry, wherein the geometry is a rectangular prism with a corresponding length, width, and height; determining a probabilistic constant based on to the geometry of the volume of the tissue; determining a ratio of mean velocity to mean path length based on the ultrasound signal response at a first time representing a transitory intensity and a second time representing a steady state intensity; and determining a mean perfusion through the volume of tissue based on the probabilistic constant, the ratio of mean velocity to mean path length, the tissue density, the width, and the height. - View Dependent Claims (11, 12)
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Specification