Haemostatic patch and method of preparation
First Claim
1. A method of preparing a haemostatic patch comprising a porous layer including oxidized cellulose and a film including neutralized chitosan, the film comprising a first free face and a second face fixed on a first face of the porous layer, comprising the following steps:
- a) preparing a porous layer including oxidized cellulose,b) preparing a film including chitosan starting from an acidic aqueous solution of chitosan,c) fixing the film obtained in b) on a face of the porous layer,d) neutralizing the film obtained in b), wherein step c) is carried out before or after step d) and the neutralizing step d) comprises treating the film with a neutralizing composition comprising at least ethanol and ammonium hydroxide.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to a haemostatic patch comprising a porous layer based on oxidized cellulose and a neutralized film based on chitosan, said film comprising a free face and a face fixed on one of the faces of the porous layer, and to the method of preparing said patch comprising the following steps: —a°) preparing a porous layer based on oxidized cellulose, —b°) preparing a film based on chitosan starting from an acidic aqueous solution of chitosan, —c°) fixing the film obtained in b°) on one face of the porous layer, —d°) neutralizing the film obtained in b°), —where step c°) can be carried out before or after step d°), characterized in that: the neutralizing step d°) comprises treatment of said film with a neutralizing composition comprising at least ethanol and ammonium hydroxide (NH4OH).
472 Citations
22 Claims
-
1. A method of preparing a haemostatic patch comprising a porous layer including oxidized cellulose and a film including neutralized chitosan, the film comprising a first free face and a second face fixed on a first face of the porous layer, comprising the following steps:
-
a) preparing a porous layer including oxidized cellulose, b) preparing a film including chitosan starting from an acidic aqueous solution of chitosan, c) fixing the film obtained in b) on a face of the porous layer, d) neutralizing the film obtained in b), wherein step c) is carried out before or after step d) and the neutralizing step d) comprises treating the film with a neutralizing composition comprising at least ethanol and ammonium hydroxide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
Specification