Methods, materials and apparatus for treating bone and other tissue
First Claim
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1. A hydraulic delivery system for delivering bone cement to a patient'"'"'s vertebra, comprising:
- a hydraulic actuator for generating a fluid pressure;
a reservoir having a quantity of bone cement contained therein, the bone cement comprising PMMA polymer and MMA monomer, the PMMA polymer having an average molecular weight and further containing a population of pre-polymerized PMMA beads having a high molecular weight, wherein the high molecular weight is greater than the average molecular weight and wherein the average molecular weight, the high molecular weight, and the percentage of beads having the high molecular weight are selected so that contacting the PMMA polymer and MMA monomer produces a mixture which has a stable high viscosity during a working time and solidifies after the working time;
a flexible tube connected to the hydraulic actuator and to the reservoir to transmit the fluid pressure from the hydraulic actuator to the reservoir; and
a cannula connected to the reservoir such that the fluid pressure from the hydraulic actuator forces bone cement from the reservoir through the cannula;
wherein the bone cement has a stable high viscosity of 200 to 2000 Pascal-second during a working time of at least 5 minutes, the bone cement solidifying after the working time; and
wherein the system is configured to deliver the bone cement to a patient'"'"'s vertebra during the working time.
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Abstract
A bone cement comprising a first component and a second component, wherein contacting the first component and the second component produces a mixture which attains a high viscosity an initial period and the viscosity of the mixture remains relatively stable for a working time of at least 5 minutes after the initial setting period, and the mixture is suitable for in-vivo use.
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Citations
35 Claims
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1. A hydraulic delivery system for delivering bone cement to a patient'"'"'s vertebra, comprising:
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a hydraulic actuator for generating a fluid pressure; a reservoir having a quantity of bone cement contained therein, the bone cement comprising PMMA polymer and MMA monomer, the PMMA polymer having an average molecular weight and further containing a population of pre-polymerized PMMA beads having a high molecular weight, wherein the high molecular weight is greater than the average molecular weight and wherein the average molecular weight, the high molecular weight, and the percentage of beads having the high molecular weight are selected so that contacting the PMMA polymer and MMA monomer produces a mixture which has a stable high viscosity during a working time and solidifies after the working time; a flexible tube connected to the hydraulic actuator and to the reservoir to transmit the fluid pressure from the hydraulic actuator to the reservoir; and a cannula connected to the reservoir such that the fluid pressure from the hydraulic actuator forces bone cement from the reservoir through the cannula; wherein the bone cement has a stable high viscosity of 200 to 2000 Pascal-second during a working time of at least 5 minutes, the bone cement solidifying after the working time; and wherein the system is configured to deliver the bone cement to a patient'"'"'s vertebra during the working time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 21, 22, 23, 28, 31)
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15. A system for delivering bone cement to a patient'"'"'s vertebra, comprising:
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a hydraulic actuator for generating a fluid pressure; a reservoir having a quantity of bone cement contained therein, the bone cement comprising PMMA polymer and MMA monomer, the PMMA polymer having an average molecular weight and further containing a population of pre-polymerized PMMA beads having a high molecular weight, wherein the high molecular weight is greater than the average molecular weight and wherein the average molecular weight, the high molecular weight, and the percentage of beads having the high molecular weight are selected so that contacting the PMMA polymer and MMA monomer produces a mixture which has a stable high viscosity during a working time and solidifies after the working time; a flexible tube connected to the hydraulic actuator and to the reservoir to transmit the fluid pressure from the hydraulic actuator to the reservoir; and a cannula connected to the reservoir such that the fluid pressure from the hydraulic actuator forces bone cement from the reservoir through the cannula; wherein the bone cement has a stable high viscosity of 200 to 2000 Pascal-second during a working time of at least 5 minutes, the stable viscosity changing by less than 20% during a period of 5 minutes and the bone cement solidifying after the working time; and wherein the system is configured to deliver the bone cement to a patient'"'"'s vertebra during the working time. - View Dependent Claims (16, 20, 24, 25, 29, 32, 34)
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17. A system for delivering bone cement to a patient'"'"'s vertebra, comprising:
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a hydraulic actuator for generating a fluid pressure; a reservoir having a quantity of bone cement contained therein, the bone cement comprising PMMA polymer and MMA monomer, the PMMA polymer having an average molecular weight and further containing a population of pre-polymerized PMMA beads having a high molecular weight, wherein the high molecular weight is greater than the average molecular weight and wherein the average molecular weight, the high molecular weight, and the percentage of beads having the high molecular weight are selected so that contacting the PMMA polymer and MMA monomer produces a mixture which has a stable high viscosity during a working time and solidifies after the working time; a flexible tube connected to the hydraulic actuator and to the reservoir to transmit the fluid pressure from the hydraulic actuator to the reservoir; and a cannula connected to the reservoir such that the fluid pressure from the hydraulic actuator forces bone cement from the reservoir through the cannula; wherein the bone cement has a stable high viscosity of 200 to 2000 Pascal-second during a working time of at least 5 minutes, the stable viscosity changing by less than 200 Pascal-seconds during a period of 2 minutes within the working time and the bone cement solidifying after the working time; and wherein the system is configured to deliver the bone cement to a patient'"'"'s vertebra during the working time. - View Dependent Claims (18, 19, 26, 27, 30, 33, 35)
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Specification