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Biodegradable nanocomposites with enhanced mechanical properties for soft tissue engineering

  • US 9,750,845 B2
  • Filed: 11/18/2013
  • Issued: 09/05/2017
  • Est. Priority Date: 09/28/2005
  • Status: Active Grant
First Claim
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1. A method, comprising:

  • (a) combining a poly(diol citrate) pre-polymer solution with a nanostructured poly(L-lactic acid) to form a mixture;

    (b) polymerizing the mixture to form a nanocomposite comprising polymerized poly(diol citrate) and nanostructured poly(L-lactic acid);

    (c) hydrolyzing the poly(L-lactic acid) during the polymerization step to form free carboxyl groups on the surface of the nanostructured poly(L-lactic acid); and

    (d) forming covalent bonds between the free carboxyl groups on the surface of the hydrolyzed poly(L-lactic acid) and the polymerized poly(diol citrate).

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