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Integrated strontium-rubidium radioisotope infusion systems

DC CAFC
  • US 9,750,869 B2
  • Filed: 12/22/2016
  • Issued: 09/05/2017
  • Est. Priority Date: 06/11/2008
  • Status: Active Grant
First Claim
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1. An infusion system on-board a cart comprising:

  • a cabinet structure that comprises;

    a platform,an exterior shell that extends upwardly above the platform and has a front side;

    a rear side;

    two sidewalls connecting the front side to the rear side; and

    a top surface;

    wherein the platform and the exterior shell collectively define an interior space of the cabinet structure and wherein the interior space of the cabinet structure is configured to receive a strontium-rubidium radioisotope generator having an inlet tubing port configured to receive saline and an outlet tubing port configured to discharge a rubidium radioactive eluate,an opening through the exterior shell configured to provide access to the strontium-rubidium radioisotope generator within the interior space of the cabinet structure, andan opening through the top surface of the exterior shell configured to provide access for inserting a waste bottle into or removing the waste bottle from the interior space of the cabinet structure;

    a computer with a touch screen display configured to receive an input from a user for controlling operation of the infusion system, wherein the touch screen display is mounted on a vertical post having a top end extending above the cabinet structure;

    a first shielding compartment in the interior space of the cabinet structure having a first opening facing vertically upwardly through which the strontium-rubidium radioisotope generator can be inserted into and removed from the first shielding compartment;

    a first door accessible via the opening through the exterior shell, the first door being configured to provide access to the first shielding compartment and to close over the first opening;

    a second shielding compartment having a second opening facing vertically upwardly through which the waste bottle can be inserted into and removed from the second shielding compartment;

    a second door accessible via the opening through the top surface of the exterior shell, the second door being configured to provide access to the second shielding compartment and to close over the second opening;

    wherein the first opening is located at a lower elevation than the second opening;

    a radioactivity detector positioned to measure radioactivity of the rubidium radioactive eluate flowing through an eluate tubing line in fluid communication with the outlet tubing port of the strontium-rubidium radioisotope generator;

    a shielded well on-board the cart configured to receive an eluate reservoir, wherein the eluate reservoir is configured to receive a test sample; and

    wherein the computer of the infusion system is configured to;

    provide a stop button on the touch screen display to abort a function of the infusion system in response to a user input activating the stop button,pump saline from a saline reservoir positioned outside of the interior space of the cabinet structure into the strontium-rubidium radioisotope generator through the inlet tubing port of the strontium-rubidium radioisotope generator thereby generating the rubidium radioactive eluate that is discharged through the outlet tubing port,fill the eluate reservoir in the shielded well on-board the cart with the test sample of the rubidium radioactive eluate,determine a strontium breakthrough test result on the test sample filled into the eluate reservoir in the shielded well on-board the cart while the eluate reservoir remains in the shielded well on-board the cart, andnot allow a patient infusion if the strontium breakthrough test result is greater than or equal to an allowed limit.

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