Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids

• US 9,750,953 B2
• Filed: 08/20/2013
• Issued: 09/05/2017
• Est. Priority Date: 06/06/2008
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Kalafut, John F.
• Primary Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US13/971,095
• Publication Number:
  US 20140046295A1
• Time in Patent Office: 1,477 Days
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 2202/0225 Carbon oxides, e.g. Carbon dioxide
• CPC Class Codes: A61M 2202/049 Toxic
• CPC Class Codes: A61M 2206/11 Laminar flow
• CPC Class Codes: A61M 2206/18 Coaxial flows, e.g. one flow within another
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/1785 comprising radioactive shield means syringe shields or holders for storage of radioactive sources G21F5/018
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: Y10T 137/0318 Processes

Abstract

Systems and methods for delivering a medical fluid are disclosed. The system includes a fluid flow path, a fluid administration device adapted to deliver the medical fluid through the fluid flow path, and a controller in communication with the fluid administration device. The method includes using the system to determine a desired flow rate of the medical fluid at a distal end of the fluid flow path based upon at least a desired flow profile of the medical fluid at the distal end. The method further includes initiating a fluid delivery operation by delivering the medical fluid through the fluid flow path according to fluid delivery parameters provided to the fluid administration device by the controller. Information about the fluid delivery operation may be received at the controller which executes a control function to adjust the fluid delivery parameters based on the received information.

Claims

1. A method of operating a system for delivering a medical fluid, the system comprising a fluid flow path, a fluid administration device adapted to deliver the medical fluid through the fluid flow path, and a controller in communication with the fluid administration device, the method comprising:

determining a desired flow rate of the medical fluid at a distal end of the fluid flow path based upon at least a desired flow profile of the medical fluid at the distal end of the fluid flow path;

initiating a fluid delivery operation by delivering the medical fluid through the fluid flow path according to fluid delivery parameters provided to the fluid administration device by the controller;

receiving, at the controller, information about the fluid delivery operation; and

executing, by the controller, a control function to adjust the fluid delivery parameters based on the received information about the fluid delivery operation.

2. The method of claim 1, wherein the received information about the fluid delivery operation includes an actual or estimated measure of a flow rate at the distal end of the fluid flow path.

3. The method of claim 2, wherein the control function adjusts the fluid delivery parameters to correct for differences between the desired flow rate of the medical fluid at the distal end and the actual or estimated measure of the flow rate at the distal end.

4. The method of claim 1, wherein the received information about the fluid delivery operation includes an estimated measure of a flow rate at the distal end of the fluid flow path.

5. The method of claim 4, wherein the estimated measure of the flow rate at the distal end of the fluid flow path is determined using a model of the fluid flow path.

6. The method of claim 5, wherein the model is based on information about at least one fluid flow path element.

7. The method of claim 6, wherein the information about the at least one fluid flow path element is provided by a data storage device associated with the at least one fluid flow path element.

8. The method of claim 1, wherein the received information about the fluid delivery operation includes an actual measure of a flow rate at the distal end of a fluid flow path.

9. The method of claim 8, wherein the actual measure of the flow rate at the distal end is determined by a flowmeter disposed at the distal end.

10. The method of claim 1, wherein the medical fluid constitutes an injection bolus and determining the desired flow rate of the medical fluid at the distal end includes determining a desired shape of the injection bolus at the distal end.

11. The method of claim 10, wherein the control function adjusts the fluid delivery parameters to achieve the desired shape of the injection bolus at the distal end.

12. The method of claim 1, wherein the fluid delivery parameters used to initiate the fluid delivery operation are determined using a model of the fluid flow path.

13. The method of claim 12, wherein the model is based on information about at least one fluid flow path element.

14. The method of claim 13, wherein the information about the at least one fluid flow path element is provided by a data storage device associated with the at least one fluid flow path element.

15. The method of claim 1, wherein the fluid administration device is selected from a syringe, a pump, a valve, and a powered injector.

16. The method of claim 1, wherein the fluid administration device is a powered injector.

17. The method of claim 16, wherein executing the control function includes adjusting a motor velocity of the powered injector.

18. The method of claim 1, where the controller is a PID controller.

19. A method for controlling the delivery of an injection bolus of a medical fluid to a patient through a fluid flow path, the method comprising:

determining a desired flow rate of the medical fluid at a distal end of the fluid flow path based upon at least a desired shape of the injection bolus at the distal end of the fluid flow path;

initiating a fluid delivery operation by delivering the medical fluid through the fluid flow path according to fluid delivery parameters provided to a powered injector by a controller;

determining an actual or estimated measure of a flow rate at the distal end of the fluid flow path; and

executing, by the controller, a control function to adjust the fluid delivery parameters based upon the actual or estimated measure of the flow rate at the distal end of the fluid flow path to improve the actual shape of the injection bolus at the distal end.

20. A system for delivering a medical fluid, the system comprising:

a fluid flow path;

a fluid administration device adapted to deliver the medical fluid through the fluid flow path; and

a controller in communication with the fluid administration device, wherein the controller is configured to receive information about a fluid delivery operation and to provide fluid delivery parameters to the fluid administration device,

wherein the controller is programmed to execute a control function to adjust the fluid delivery parameters based, at least in part, on the information about the fluid delivery operation received by the controller,

wherein the information about the fluid delivery operation received includes an actual or estimated measure of a flow rate of the medical fluid at a distal end of the fluid flow path.

21. The method of claim 20, wherein the control function adjusts the fluid delivery parameters to correct for differences between a desired flow rate of the medical fluid at the distal end and the actual or estimated measure of the flow rate at the distal end.

22. The system of claim 20, wherein the fluid administration device is a powered injector.

23. The system of claim 20, wherein the controller is a PID controller.

24. The system of claim 20, wherein the distal end of the fluid flow path includes a connection to an IV catheter.

25. The system of claim 20, wherein the controller is programmed to execute the control function to adjust the fluid delivery parameters to achieve a desired shape of an injection bolus at the distal end.