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Methods of producing isoprene and a co-product

  • US 9,752,161 B2
  • Filed: 01/06/2014
  • Issued: 09/05/2017
  • Est. Priority Date: 12/30/2008
  • Status: Expired due to Fees
First Claim
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1. Recombinant host cells comprising (a) a heterologous nucleic acid encoding an isoprene synthase polypeptide, (b) a nucleic acid encoding an isopentenyl-diphosphate delta-isomerase (IDI) polypeptide, (c) nucleic acid(s) encoding a 1-Deoxyxylulose-5-phosphate synthase (DXS) polypeptide and/or one or more mevalonate (MVA) pathway polypeptides and (d) heterologous nucleic acid(s) encoding (i) one or more polypeptide involved in ethanol fermentation, wherein the polypeptide involved in ethanol fermentation is an alcohol dehydrogenase from yeast or bacteria, or (ii) a pyruvate decarboxylase (pdc) polypeptide,wherein said cells co-produce isoprene and ethanol under oxygen-limited culture conditions, wherein the oxygen transfer rate (OTR) is less than the oxygen uptake rate (OUR).

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