Characterization and/or detection of structural characteristics associated with syringes and/or automatic injection devices based on acoustics

• US 9,753,015 B2
• Filed: 10/11/2013
• Issued: 09/05/2017
• Est. Priority Date: 10/12/2012
• Status: Active Grant

• Current Assignee: Abbvie Incorporated
• Original Assignee: Abbvie Incorporated
• Inventors: Bardina, Jose L., Dragicevic, Jovo, Rodriguez, Jose M., Sita, Lewis H.
• Primary Examiner(s): Kwok, Helen
• Application Number:
  US14/434,050
• Publication Number:
  US 20150253289A1
• Time in Patent Office: 1,425 Days
• CPC Class Codes: A61M 2209/02 Equipment for testing the apparatus
• CPC Class Codes: A61M 5/178 Syringes
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/5086 for indicating if defective, used, tampered with or unsterile
• CPC Class Codes: G01H 1/00 Measuring characteristics of vibrations in solids by using direct conduction to the detector G01H9/00, G01H11/00 take precedence
• CPC Class Codes: G01H 17/00 Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves, not provided for in the preceding groups see provisionally also G01H1/00
• CPC Class Codes: G01M 7/022 Vibration control arrangements, e.g. for generating random vibrations
• CPC Class Codes: G01M 7/025 Measuring arrangements
• CPC Class Codes: G01M 7/027 Specimen mounting arrangements, e.g. table head adapters
• CPC Class Codes: G01N 2291/0289 Internal structure, e.g. defects, grain size, texture
• CPC Class Codes: G01N 2291/2698 Other discrete objects, e.g. bricks
• CPC Class Codes: G01N 29/045 by imparting shocks to the workpiece and detecting the vibrations or the acoustic waves caused by the shocks measuring resonant frequency G01H13/00; measuring strength properties by application of mechanical stress G01N3/00
• CPC Class Codes: G01N 29/12 by measuring frequency or resonance of acoustic waves measuring frequency or resonant frequency of mechanical vibrations or acoustic waves in general G01H1/06, G01H3/04, G01H13/00; acoustic resonators G10K11/04; vibration or shock testing of structures G01M7/00

Abstract

System and methods for characterizing and/or detecting structural characteristics of syringes (e.g., bare syringes or syringes included in automatic injection devices) using acoustic vibrations. A transducer is positioned proximate to a syringe so that the transducer vibrates at one or more frequencies and a response of the syringe to the vibrations can be received via the receiver. The response of syringe can be processed to determine a structural characteristic of the syringe.

Claims

1. A syringe structural characterization system comprising:

a transducer to output a first signal proximate to a syringe pre-filled with a fluid and incorporated in a housing substantially surrounding the syringe;

a receiver to receive a response of the syringe to the first signal; and

a processing device configured to control the transducer and the receiver to determine a structural characteristic of the syringe based on the response received by the receiver;

wherein at least one of the transducer and the receiver are configured to physically contact the syringe.

2. The syringe structural characterization system of claim 1, wherein the transducer is configured to vibrate at one or more frequencies and the receiver is configured to detect a syringe response to vibrations of the transducer.

3. The syringe structural characterization system of any one of claim 1, further comprising:

an adjustable stage operatively coupled to the transducer to position the transducer in proximity to the syringe.

4. The syringe structural characterization system of any one of claim 1, further comprising:

an adjustable stage operatively coupled to the receiver to position the receiver in proximity to the syringe.

5. The syringe structural characterization system of any one of claim 1, wherein the receiver is an acoustic sensor configured to measure the response.

6. The syringe structural characterization system of any one of claim 1, wherein the transducer and the receiver are positioned at a substantially similar location along a longitudinal axis of the syringe and radially offset from each other.

7. The syringe structural characterization system of claim 6, wherein the transducer and the syringe are radially offset by about one hundred eighty degrees.

8. The syringe structural characterization system of any one of claim 1, wherein the syringe is incorporated in an automatic injection device, the automatic injection device including the housing and the housing including openings through which the transducer and the receiver pass to position the transducer and the receiver in proximity to the syringe.

9. The syringe structural characterization system of any one of claim 1, wherein the structural characteristic is at least one of a crack and a scratch and the structural characteristic is detected based on a comparison between response parameters of the syringe and parameter limits corresponding to a characterization of one or more control syringes having like syringe attributes as the syringe.

10. The syringe structural characterization system of claim 9, wherein the response parameters include at least one of a peak amplitude of the response, a frequency at which the peak amplitude occurs, and a bandwidth of the response.

11. A system for characterizing a syringe based on structural characteristics of the syringe comprising:

a transducer configured to vibrate at one or more frequencies;

a receiver to detect a syringe response to vibrations of the transducer, the syringe pre-filled with a fluid and incorporated in a housing substantially surrounding the syringe; and

a syringe characterization unit configured to characterize the response detected by the receiver;

wherein at least one of the transducer and the receiver are configured to physically contact the syringe.

12. The system of claim 11, wherein the syringe characterization unit identifies response parameters for the response and characterizes the response by generating a signature based on the response parameters.

13. The system of claim 12, wherein the response parameters include at least one of a peak amplitude of the response, a frequency at which the peak amplitude occurs, and a bandwidth of the response.

14. The system of claim 12, wherein the signature comprises at least one of an upper limit associated with a peak amplitude, a lower limit associated with a peak amplitude, an upper limit associated with a frequency at which a peak amplitude occurs, a lower limit associated with a frequency at which a peak amplitude occurs, an upper limit associated with a bandwidth of the response, and a lower limit associated with a bandwidth of the response.

15. A non-transitory computer readable medium storing processor executable instructions, wherein execution of the instructions by a processing device causes the processing device to:

control a transducer to vibrate at one or more frequencies;

receive a response of a syringe pre-filled with a fluid to vibrations of the transducer, the syringe incorporated in a housing surrounding the syringe, and at least one of the transducer and the receiver are configured to physically contact the syringe; and

process the response to determine a structural characteristic of the syringe based on the response received the receiver.

16. The non-transitory medium of claim 15, wherein execution of the instructions by the processing device causes the processing device to compute a signature corresponding to the response of the syringe, the signature characterizing the syringe.

17. The non-transitory medium of claim 15, wherein the syringe is incorporated in an automatic injection device, the automatic injection device including the housing, and the housing including openings through which the transducer and the receiver pass to position the transducer and the receiver in proximity to the syringe.

18. The non-transitory medium of claim 15, wherein the structural characteristic is at least one of a crack and a scratch and execution of the instructions by the processing device causes the processing device to detected the structural characteristic based on a comparison between response parameters of the syringe and parameter limits corresponding to a characterization of one or more control syringes having like syringe attributes as the syringe.

19. A method of detecting a structural characteristic of a syringe comprising:

inducing vibrations in one or more syringes;

measuring a response of a syringe pre-filled with a syringe to the vibrations, the syringe is incorporated in a housing substantially surrounding the syringe;

positioning the transducer proximate to the syringe to induce vibrations in the syringe; and

positioning the receiver proximate to the syringe to receive the response of the syringe to the vibrations;

wherein at least one the transducer and the receiver are configured to physically contact the syringe.

20. The method of claim 19, further comprising processing the response to identify response parameters including at least one of a peak amplitude of the response, a frequency at which the peak amplitude occurs, and a bandwidth of the response.

21. The method of claim 20, further comprising characterizing the syringe based on the response parameters.

22. The method of claim 21, wherein characterizing the syringe comprising generating at least one upper limit and at least one lower limit for at least one of the peak amplitude, the frequency at which the peak amplitude occurs, and the bandwidth of the response.

23. The method of claim 21, wherein the at least one upper limit and at least one lower limit are based on a statistical analysis of the response parameters for a plurality of syringes.

24. The method of claim 20, further comprising detecting a structural characteristic of the syringe based on the response parameters.

25. The method of claim 24, wherein the detecting the structural characteristic comprises comparing at least one of the response parameters to a predetermined limit.