High spatial resolution mode solid state positron emission tomography (PET) scanner

• US 9,753,153 B2
• Filed: 07/15/2013
• Issued: 09/05/2017
• Est. Priority Date: 07/30/2012
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Griesmer, Jerome John, Laurence, Thomas Leroy
• Primary Examiner(s): Green, Yara B
• Application Number:
  US14/416,070
• Publication Number:
  US 20150192685A1
• Time in Patent Office: 1,513 Days
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: G01T 1/1647 Processing of scintigraphic data not related to a particular imaging system G01T1/2992
• CPC Class Codes: G01T 1/20182 Modular detectors, e.g. tiled scintillators or tiled photodiodes stacked detectors G01T1/20181
• CPC Class Codes: G01T 1/208 Circuits specially adapted for scintillation detectors, e.g. for the photo-multiplier section
• CPC Class Codes: G01T 1/2985 In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); using external radiation sources A61B6/02

Abstract

A positron emission tomography (PET) system (10) and method (100) classifies gamma events. At least one processor (62, 66, 70) is programmed to receive event data for a plurality of scintillation events corresponding to gamma events. The gamma events are generated by gamma photons from a region of interest (ROI) (14). The gamma events of the event data are classified into a plurality of classifications. The classifications distinguish between single-crystal gamma events and multi-crystal gamma events.

Claims

1. A positron emission tomography (PET) system, said system comprising:

at least one processor programmed to;

receive event data for a plurality of scintillation events corresponding to gamma events, the gamma events generated by gamma photons from a region of interest (ROI);

cluster the scintillation events based on time to create a plurality of clusters, each cluster corresponding to a different one of the gamma events;

determine a classification of the gamma event corresponding to each cluster based on a spatial configuration and a number of each cluster, the classifications distinguishing between single-crystal gamma events and multi-crystal gamma events, wherein the classifications indicate whether gamma energy was deposited in;

     1) a single crystal;

     2) two adjacent crystals;

     3) two non-adjacent crystals; and

     4) more than two crystals;

generate a first image representation of the ROI using only single-crystal gamma events;

generate additional image representations of the ROI corresponding to the classifications;

weight each additional image representation based on the classification; and

,

combine the first image and the weighted additional images to generate the image representation of the ROI.

2. The positron emission tomography (PET) system according to claim 1, wherein the classifications indicate whether gamma energy was deposited in:

1) a single crystal;

     2) two adjacent crystals;

     3) two non-adjacent crystals; and

     4) more than two crystals.

3. The PET system according to claim 1, further including:

a display configured to display the image representation of the ROI.

4. The PET system according to claim 1, further including:

a plurality of detectors, each detector includes a plurality of opto-electric transducers optically coupled in a 1;

1 ratio with a plurality of scintillation crystals, the opto-electric transducers detecting scintillation events generated in the scintillation crystals by the gamma photons.

5. A positron emission tomography (PET) system, the system comprising:

at least one processor programmed to;

receive event data for a plurality of scintillation events corresponding to gamma events, the gamma events generated by gamma photons from a region of interest (ROI);

generate lines of response corresponding to pairs of coincident gamma events, each radiation event being generated based on light from one or more crystals of a radiation detector;

cluster the scintillation events based on time to create a plurality of clusters, each cluster corresponding to a different one of the gamma events;

determine the one or more crystals detecting each gamma event corresponding to the cluster;

classify the gamma event corresponding to each cluster based on a spatial configuration and a number of the determined crystals;

weight each line of response based on the classifications of its pair of concurrent gamma events; and

generate an image representation of the ROI using the weighted lines of response, wherein a weight given to a line of response decreases as the number of crystals the pair of gamma events spans increases.

6. The PET system according to claim 5, further including:

a device display configured to display the image representation of the ROI.

7. A positron emission tomography (PET) method, comprising:

with one or more computer processors, clustering scintillation events based on time to create a plurality of clusters, each cluster corresponding to a different one of the gamma events;

with the one or more computer processors, for each of the clusters;

receiving event data for a plurality of scintillation events corresponding to the gamma events, the gamma events generated by gamma photons from a region of interest (ROI),

determining pixels detecting energy of the gamma event corresponding to the cluster;

classifying the gamma events corresponding to each cluster into a plurality of classifications based on a spatial configuration and a number of the determined pixels over which the gamma events of the cluster are distributed;

generating lines of response corresponding to pairs of concurrent gamma events,

determining weighting for each of the classifications, and one of;

reconstructing a plurality of images corresponding to the classifications, weighting each image based on the weightings of the corresponding classification, combining the weighted images to generate an image representation of the ROI, or

weighting each line of response based on the classifications of the corresponding pair of gamma events and reconstructing the weighted lines of response to generate an image representation of the ROI.

8. The PET method according to claim 7, further including:

with a display device, displaying the image representation of the ROI.

9. The PET method according to claim 7, wherein the weighting of the gamma events decreases as the number of crystals the gamma event spans increases.

10. The PET method according to claim 7 wherein the classifications indicate of whether gamma energy was deposited in:

1) a single crystal;

     2) two adjacent crystals;

     3) two non-adjacent crystals; and

     4) more than two crystals.

11. A non-transitory computer-readable medium carrying software configured to control a computer processor to perform the PET method according to claim 7.

12. The PET method according to claim 10, wherein the image of the ROI is generated with a hybrid mode, and wherein the image of the ROI includes:

generating a first image representation of the ROI using only single-crystal gamma events of the gamma events;

generating a second image representation of the ROI using the gamma events deposited in two crystals;

generating a third image representation using all of the gamma events;

weighting the first image representation with a weighting determined for the single-crystal gamma event classification;

weighting the second image representation with a weighting determined for the two-crystal gamma event classification;

weighting the third image representation with a weighting determined for the more than two-crystal gamma event classification; and

,

combining the weighted first, second, and third images to generate the image representation of the ROI.

13. A positron emission tomography (PET) system for classifying gamma events, said system comprising:

a plurality of detector modules receiving gamma photons from a region of interest (ROI) and generating event data for a plurality of scintillation events corresponding to gamma events generated by the gamma photons, wherein each of the plurality of detectors includes a plurality of opto-electric transducers optically coupled in a 1;

1 ratio with a plurality of scintillation crystals, the opto-electric transducers detecting the scintillation events, the scintillation events being generated in the scintillation crystals; and

,

at least one processor programmed to;

receive the event data for the scintillation events;

classify the gamma events of the event data into a plurality of classifications, each classification indicating one of single-crystal gamma events, gamma events spanning two crystals, and gamma events spanning more than two crystals;

determine lines of response extending between a pair of coincident gamma events;

weight each line of response based on the classifications of the pair of coincident gamma events; and

reconstruct the weighted lines of response into the image representation of the ROI.

14. The PET system according to claim 13, where the processor is further programmed to:

receive a selection of one of a plurality of reconstruction modes, the selection associated with one or more of the classifications; and

,

generate an image representation of the ROI and/or a sinogram using only gamma events corresponding to the classifications associated with the selected reconstruction mode and further including;

a display device configured to display the image representation of the ROI.

15. A positron emission tomography (PET) system for classifying gamma events, said system comprising:

a plurality of detector modules receiving gamma photons from a region of interest (ROI) and generating event data for a plurality of scintillation events corresponding to gamma events generated by the gamma photons, wherein each of the plurality of detectors includes a plurality of opto-electric transducers optically coupled in a 1;

1 ratio with a plurality of scintillation crystals, the opto-electric transducers detecting the scintillation events, the scintillation events generated in the scintillation crystals; and

,

at least one processor programmed to;

receive the event data for the scintillation events;

classify the gamma events of the event data into a plurality of classifications, each classification indicating one of single-crystal gamma events, gamma events spanning two crystals, and gamma events spanning more than two crystals;

reconstruct a first image based on the single-crystal gamma events;

generate a second image based on gamma events spanning up to two crystals;

reconstruct a third image representation based on all gamma events;

weight each of the first, second, and third images with weighting factors corresponding to the single-crystal events, gamma events spanning up to two crystals, and all gamma events, respectively; and

combine the weighted first, second, and third images to generate an image representation of the ROI.