Encoded biosensors and methods of manufacture and use thereof

• US 9,754,708 B2
• Filed: 08/11/2015
• Issued: 09/05/2017
• Est. Priority Date: 07/29/2011
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: Moore, Steven, Riggles, Randall
• Primary Examiner(s): Ball, J. Christopher
• Application Number:
  US14/822,963
• Publication Number:
  US 20150362455A1
• Time in Patent Office: 756 Days
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 33/48771 Coding of information, e.g. calibration data, lot number
• CPC Class Codes: H01C 17/00 Apparatus or processes specially adapted for manufacturing resistors providing fillings for housings or enclosures H01C1/02; reducing insulation surrounding a resistor to powder H01C1/03; manufacture of thermally variable resistors H01C7/02, H01C7/04
• CPC Class Codes: Y10T 29/49083 Heater type

Abstract

A sensor includes a non-conductive substrate and a circuit on the non-conductive substrate. The circuit includes a primary resistive element on the non-conductive substrate having a first end and a second end, wherein the primary resistive element has a predetermined configuration; a secondary resistive element on the non-conductive substrate having a plurality of taps connected to the primary resistive element at a plurality of predetermined connection points on the predetermined configuration, the plurality of predetermined connection points defining a plurality of unique resistive paths through at least a portion of the predetermined configuration; and the plurality of unique resistive paths having a plurality of resistance values, the plurality resistance values determined using a non-linear distribution function. A sensor is configured to perform at least one of quantitative and qualitative analysis of an analyte in a sample of fluid.

Claims

1. A sensor, the sensor comprising:

a non-conductive substrate;

a circuit on the non-conductive substrate, the circuit comprising;

a primary resistive element on the non-conductive substrate having a first end and a second end, wherein the primary resistive element has a predetermined configuration;

a secondary resistive element on the non-conductive substrate having a plurality of non-uniformly distributed taps connected to the primary resistive element at a plurality of predetermined connection points on the predetermined configuration, the plurality of predetermined connection points defining a plurality of unique resistive paths through at least a portion of the predetermined configuration;

the plurality of unique resistive paths having a plurality of resistance values, the plurality resistance values determined using a non-linear distribution function; and

the sensor configured to perform at least one of quantitative and qualitative analysis of an analyte in a sample of fluid;

wherein at least one of the plurality of taps that are connected in the predetermined configuration that define at least one of the plurality of unique resistive paths is formed in a closed state and all other taps of the plurality of taps are formed in an open state.

2. The sensor of claim 1, and wherein the non-linear distribution function is a power function.

3. The sensor of claim 2, wherein the power function is represented by the equation Rsum=R1*α

^N.

4. The sensor of claim 1, wherein each of the plurality of unique resistive paths are associated with an attribute of the sensor.

5. The sensor of claim 1, wherein the first end of the primary resistive element is connected with a first contact pad and the second end of the primary resistive element is connected with a second contact pad, and wherein a third end of the secondary resistive element is connected with a third contact pad.

6. The sensor of claim 5, wherein the unique resistive path runs from the third contact pad through the secondary resistive element and then into the primary resistive element at one of the plurality of predetermined connection points and then through at least a portion of the primary resistive element to one of the first contact pad and the second contact pad.

7. The sensor of claim 5, wherein the first contact pad and the second contact pad can be used to make Kelvin connections to determine a resistance of the primary resistance path compensating for contact resistances of the first contact pad and the second contact pad.

8. An analyte test sensor, comprising:

a non-conductive substrate;

a primary resistive element on the non-conductive substrate having a predetermined configuration, the predetermined configuration having a first end connected with a first contact pad and a second end connected to a second contact pad;

a secondary resistive element on the non-conductive substrate having a plurality of non-uniformly distributed taps, wherein one tap of the plurality of taps is connected to the primary resistive element at a predetermined location thereby being formed in a closed state and defining a unique resistive path through the primary resistive network and remaining taps of the plurality of taps being formed in an open state thereby being disconnected from the primary resistive network, wherein a portion of the secondary resistive element is connected with a secondary resistive element contact pad, and wherein each tap of the plurality of taps are associated with one of a plurality of predetermined resistance values, the plurality of predetermined resistance values having a non-linear distribution.

9. The analyte test sensor of claim 8, wherein the plurality of taps in the open state are ablated with a laser.

10. The analyte test sensor of claim 8, wherein the unique resistive path is associated with an attribute of the analyte test sensor.

11. The analyte test sensor of claim 8, wherein the non-linear distribution of the plurality of resistance values is a power function distribution.

12. The analyte test sensor of claim 8, wherein at least one of the first contact pad and the second contact pad can be used to make Kelvin connections to determine a resistance of the primary resistance path compensating for contact resistances of the at least one the first contact pad and the second contact pad.

13. A method of forming a circuit on a biosensor test strip, the method comprising:

forming a primary resistive element on a non-conductive substrate having a predetermined configuration including a first end and a second end; and

forming a secondary resistive element on the non-conductive substrate having at least one of a plurality of taps connected to a predetermined connection location on the primary resistive element thereby defining a plurality of unique resistive paths through at least a portion of the primary resistive element, each of the plurality of taps having associated therewith a resistance falling within a respective one of a plurality of ranges of resistances, wherein each of the range of resistances are determined based on a non-linear distribution function.

14. The method of claim 13, wherein all of the plurality of taps but the tap connected to the predetermined location on the primary resistive element are ablated thereby disconnecting the ablated taps from the primary resistive element.

15. The method of claim 14, wherein the primary resistive element includes a plurality of predetermined connection locations, the method further comprising the step of selecting a connection location to be connected with the tap as a function of an attribute associated with the biosensor test strip.

16. The method of claim 13, wherein the non-linear distribution function is a power function.

17. The method of claim 13, wherein the power function is represented by the equation Rsum=R1*α

^N.

18. The method of claim 13, wherein each of the plurality of unique resistive paths are associated with an attribute of the biosensor test strip.

19. The method of claim 15, wherein each of the resistances contained in the plurality of ranges of resistances is associated with a unique attribute of the biosensor test strip.

20. A biosensor test strip comprising:

a non-conductive substrate having a circuit thereon, the circuit comprising;

a primary resistive element on the non-conductive substrate having a first end and a second end, wherein the primary resistive element has a predetermined configuration; and

a secondary resistive element on the non-conductive substrate, the secondary resistive element having a plurality of taps connected to the primary resistive element at a plurality of predetermined connection points on the predetermined configuration, the plurality of predetermined connection points defining a plurality of unique resistive paths through at least a portion of the predetermined configuration, the plurality of unique resistive paths having resistance values that are non-linearly distributed; and

a sensor configured to perform at least one of quantitative and qualitative analysis of an analyte in a sample of fluid.

21. The biosensor test strip of claim 20, wherein the secondary resistive element is asymmetrical.

22. The biosensor test strip of claim 20, wherein the plurality of taps are a set of non-uniformly distributed resistor taps.