Compositions, methods and devices for maintaining an organ
First Claim
1. A system for preserving, resuscitating or evaluating a human or human-compatible lung ex vivo in a functioning and viable state comprising:
- a ventilation machine for ventilating the lung ex vivo;
a container for holding said lung and keeping said lung in communication with a fluid media, wherein the fluid media comprises a preservation solution;
a perfusion circuit comprising;
a first fluid line in fluid communication with said lung configured to deliver said fluid media to at least one major vessel of said lung when the lung is held in the container;
a second fluid line in fluid communication with the container configured to carry said fluid media away from said lung;
a heater, a cooler, or both, configured to maintain the temperature of said lung at a temperature of greater than 25°
C. to about 37°
C.;
a gas exchange device configured to controllably alter a composition of a first gas component in the fluid media;
a pump configured to control the flow rate of at least a portion of said fluid media; and
wherein said ventilation machine, said first fluid line, said second fluid line, said heater and/or cooler, said oxygenator and said pump for preserving, resuscitating or evaluating said lung in a functioning and viable state.
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0 Petitions
Accused Products
Abstract
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a preservation chamber for storing the organ during the preservation period. A perfusion circuit is provided having a first line for providing an oxygenated fluid to the organ, and a second line for carrying depleted fluid away from the organ. The perfusion apparatus also includes a device operably associated with the perfusion circuit for maintaining the organ at a substantially normothermic temperature.
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Citations
25 Claims
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1. A system for preserving, resuscitating or evaluating a human or human-compatible lung ex vivo in a functioning and viable state comprising:
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a ventilation machine for ventilating the lung ex vivo; a container for holding said lung and keeping said lung in communication with a fluid media, wherein the fluid media comprises a preservation solution; a perfusion circuit comprising; a first fluid line in fluid communication with said lung configured to deliver said fluid media to at least one major vessel of said lung when the lung is held in the container; a second fluid line in fluid communication with the container configured to carry said fluid media away from said lung; a heater, a cooler, or both, configured to maintain the temperature of said lung at a temperature of greater than 25°
C. to about 37°
C.;a gas exchange device configured to controllably alter a composition of a first gas component in the fluid media; a pump configured to control the flow rate of at least a portion of said fluid media; and wherein said ventilation machine, said first fluid line, said second fluid line, said heater and/or cooler, said oxygenator and said pump for preserving, resuscitating or evaluating said lung in a functioning and viable state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system for preserving, resuscitating or evaluating at least one human or human-compatible harvested lung comprising:
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a ventilation machine; a container for holding said lung and keeping said lung in communication with a fluid media, wherein the fluid media comprises a preservation solution; a preservation circuit comprising; at least one fluid delivery line in fluid communication with the lung configured to deliver said fluid media to at least one major vessel of said lung when the lung is held in the container; and at least one fluid return line in fluid communication with the lung configured to carry said fluid media away from the lung; a heater, a cooler, or both, configured to maintain the temperature of said lung at a temperature of greater than 25°
C. to about 37°
C.;a gas exchange device configured to oxygenate at least a portion of said fluid media; and a pump configured to control the flow rate of at least a portion of said fluid media. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method of maintaining an ex vivo lung in a near physiologic state, the method comprising:
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placing a lung in a container; ventilating the lung; pumping the perfusion fluid in a perfusion circuit coupled to the lung to provide the perfusion fluid to a pulmonary artery of the lung; heating the perfusion fluid to a temperature of greater than 25°
C. to about 37°
C.;receiving the perfusion fluid from the lung in a reservoir, containing the perfusion fluid in the reservoir; measuring a parameter of the perfusion fluid in the perfusion circuit; and controlling at least one of the pumping and the heating in response to the measured parameter.
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Specification