Compositions, methods and devices for maintaining an organ
First Claim
1. A system for preserving, resuscitating or evaluating at least one human or human-compatible harvested organ in a functioning and viable state comprising:
- a container for holding said organ and keeping said organ in communication with a fluid media, wherein the fluid media comprises a (i) preservation solution and (ii) a component of whole blood;
a first fluid line in fluid communication with the organ configured to deliver said fluid media to at least one major vessel of said organ when the organ is held in the container;
a second fluid line in fluid communication with the organ configured to carry said fluid media away from said organ;
a heater, a cooler, or both, configured to maintain the temperature of said organ at a temperature of greater than 25°
C. to about 37°
C.;
an oxygenator for oxygenating at least a part of said fluid media; and
a pump configured to control the flow rate of at least a portion of said fluid media;
wherein said preservation solution comprises;
(a) a metabolizable carbohydrate;
(b) sodium chloride;
(c) a potassium ion; and
(d) a magnesium ion;
wherein said first fluid line, said second fluid line, said heater and/or cooler, said oxygenator and said pump simulate the donor physiological system for maintaining said organ in a functioning and viable state.
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0 Petitions
Accused Products
Abstract
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a preservation chamber for storing the organ during the preservation period. A perfusion circuit is provided having a first line for providing an oxygenated fluid to the organ, and a second line for carrying depleted fluid away from the organ. The perfusion apparatus also includes a device operably associated with the perfusion circuit for maintaining the organ at a substantially normothermic temperature.
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Citations
17 Claims
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1. A system for preserving, resuscitating or evaluating at least one human or human-compatible harvested organ in a functioning and viable state comprising:
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a container for holding said organ and keeping said organ in communication with a fluid media, wherein the fluid media comprises a (i) preservation solution and (ii) a component of whole blood; a first fluid line in fluid communication with the organ configured to deliver said fluid media to at least one major vessel of said organ when the organ is held in the container; a second fluid line in fluid communication with the organ configured to carry said fluid media away from said organ; a heater, a cooler, or both, configured to maintain the temperature of said organ at a temperature of greater than 25°
C. to about 37°
C.;an oxygenator for oxygenating at least a part of said fluid media; and a pump configured to control the flow rate of at least a portion of said fluid media; wherein said preservation solution comprises; (a) a metabolizable carbohydrate; (b) sodium chloride; (c) a potassium ion; and (d) a magnesium ion; wherein said first fluid line, said second fluid line, said heater and/or cooler, said oxygenator and said pump simulate the donor physiological system for maintaining said organ in a functioning and viable state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A system for preserving, resuscitating or evaluating at least one human or human-compatible harvested organ comprising:
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a container for holding said organ and keeping said organ in communication with a fluid media, wherein the fluid media comprises a (i) preservation solution and (ii) a component of whole blood; a preservation circuit comprising; at least one fluid delivery line in fluid communication with the organ configured to deliver said fluid media to at least one major vessel of said organ when said organ is held in the container; and at least one fluid return line in fluid communication with the organ configured to carry said fluid media away from the organ; a heater, a cooler, or both, configured to maintain the temperature of said organ at a temperature of greater than 25°
C. to about 37°
C.;an oxygenation device configured to oxygenate at least a portion of said fluid media; and a pump configured to control the flow rate of at least a portion of said fluid media wherein said preservation solution comprises; (a) a metabolizable carbohydrate; (b) sodium chloride; (c) a potassium ion; and (d) a magnesium ion.
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Specification