System and method for adaptive drug delivery
First Claim
1. A method of controlling delivery of medication with an electronic medication delivery controller, comprising the steps of:
- sampling, using at least one physiological sensor, data from a patient during the delivery of medication to the patient by a medication delivery unit;
establishing, using said electronic medication delivery controller, a medication response profile;
repeatedly updating, using said electronic medication delivery controller, in a closed loop process, the medication response profile using said data sampled from the patient by adapting parameters of said medication response profile, said medication response profile being indicative of a relationship between a concentration of the medication and an effect of the medication;
minimizing, using said electronic medication delivery controller, the error between said updated medication response profile and the said sampled data; and
adjusting, using said electronic medication delivery controller, the delivery of medication to the patient by the medication delivery unit based on the updated medication response profile.
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Abstract
The present invention provides a system and method for determining and maintaining a concentration level of medication in a patient sufficient to achieve and maintain a desired effect on that patient. Generally speaking, in accordance with one embodiment of the invention, a medication delivery controller uses a patient response profile to determine a concentration of medication in the patient that will achieve the desired effect on the patient. The patient response profile is a graphical, tabular or analytical expression of the relationship between the concentration of a medication and the effect of the medication at the specific concentration. Using this information, the medication delivery controller provides instructions to a medication delivery unit such as, for example, an infusion pump or inhalation device, to deliver the medication to the patient at a rate that will achieve the desired concentration level of the medication in the patient.
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Citations
15 Claims
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1. A method of controlling delivery of medication with an electronic medication delivery controller, comprising the steps of:
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sampling, using at least one physiological sensor, data from a patient during the delivery of medication to the patient by a medication delivery unit; establishing, using said electronic medication delivery controller, a medication response profile; repeatedly updating, using said electronic medication delivery controller, in a closed loop process, the medication response profile using said data sampled from the patient by adapting parameters of said medication response profile, said medication response profile being indicative of a relationship between a concentration of the medication and an effect of the medication; minimizing, using said electronic medication delivery controller, the error between said updated medication response profile and the said sampled data; and adjusting, using said electronic medication delivery controller, the delivery of medication to the patient by the medication delivery unit based on the updated medication response profile. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A medication delivery system comprising:
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at least one physiological sensor for sampling data from a patient during delivery of medication to the patient by a medication delivery unit; and a medication delivery controller comprising a processor that is configured to; establish a medication response profile; update said medication response profile using said data sampled from the patient by adapting parameters of said medication response profile, said medication response profile indicative of a relationship between a concentration of the medication and an effect of the medication; minimize an error between said sampled data and said updated medication response profile; and adjust the delivery of medication to the patient by the medication delivery unit based on the updated medication response profile.
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Specification