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Dry insertion and one-point in vivo calibration of an optical analyte sensor

  • US 9,757,057 B2
  • Filed: 11/06/2013
  • Issued: 09/12/2017
  • Est. Priority Date: 11/07/2012
  • Status: Active Grant
First Claim
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1. A method for monitoring glucose concentration in a physiological fluid in a patient, comprising:

  • providing a sensor comprising an equilibrium fluorescence chemical indicator system immobilized in a hydrogel disposed along a distal region of an optical fiber, wherein the hydrogel comprising the immobilized chemical indicator system is in a dry state;

    deploying the distal region of the optical fiber in the physiological fluid, wherein the hydrogel with immobilized chemical indicator system disposed along the distal region of the optical fiber is deployed in a dry state;

    allowing the hydrogel with immobilized chemical indicator system to hydrate in vivo in the physiological fluid;

    after in vivo hydration, performing an in vivo calibration of the fluorescent response of the immobilized chemical indicator system against an independently measured glucose concentration in the physiological fluid; and

    monitoring the glucose concentration in the physiological fluid after calibration.

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