Titanium nano-scale etching on an implant surface

• US 9,757,212 B2
• Filed: 03/10/2016
• Issued: 09/12/2017
• Est. Priority Date: 03/29/2010
• Status: Active Grant

• Current Assignee: Biomet 3i LLC (Zimvie Incorporated)
• Original Assignee: Biomet 3i LLC (Zimvie Incorporated)
• Inventors: Mayfield, Robert L, Towse, Ross W
• Primary Examiner(s): Deo, Duy
• Application Number:
  US15/066,213
• Publication Number:
  US 20160184059A1
• Time in Patent Office: 551 Days
• CPC Class Codes: A61C 13/00 Dental prostheses; Making same tooth crowns for capping teeth A61C5/70; dental implants A61C8/00
• CPC Class Codes: A61C 2008/0046 Textured surface, e.g. roughness, microstructure A61C8/0013 takes precedence
• CPC Class Codes: A61C 8/00 Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools fastening of peg-teeth in the mouth A61C13/30
• CPC Class Codes: A61C 8/0012 characterised by the material or composition, e.g. ceramics, surface layer, metal alloy use of specific materials A61K6/00
• CPC Class Codes: A61C 8/0013 with a surface layer, coating
• CPC Class Codes: A61C 8/0015 being a conversion layer, e.g. oxide layer
• CPC Class Codes: A61C 8/0022 Self-screwing A61C8/0028 takes precedence
• CPC Class Codes: A61C 8/0037 Details of the shape
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/04 Metals or alloys
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C23F 1/00 Etching metallic material by chemical means manufacture of printing surfaces B41C; manufacture of printed circuits H05K
• CPC Class Codes: C23F 1/26 for etching refractory metals
• CPC Class Codes: C23F 1/30 for etching other metallic material
• CPC Class Codes: C23F 1/38 for etching refractory metals
• CPC Class Codes: C23G 1/106 refractory metals

Abstract

A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises the act of immersing the microscale roughened surface into a solution containing hydrogen peroxide and a basic solution to produce a nanoscale roughened surface consisting of nanopitting superimposed on the microscale roughened surface. The nanoscale roughened surface has a property that promotes osseointegration.

Claims

1. An implant to be implanted into living bone, comprising:

a head portion having a non-rotational features;

a lowermost end opposing the head portion; and

a threaded bottom portion for engaging bone between the head portion and the lowermost end, wherein a portion of a surface of the implant has a microscale roughened surface and a nanoscale roughened surface superimposed on the microscale roughened surface, the nanoscale roughened surface including nanopitting superimposed on the microscale roughened surface.

2. The implant of claim 1, wherein the implant is made of metal selected form the group consisting of tantalum, cobalt, chromium, titanium, stainless steel, or alloys thereof.

3. The implant of claim 1, wherein the implant is a dental implant.

4. The implant of claim 1, wherein the portion of the surface of the implant is the threaded bottom portion for facilitating bonding with bone.

5. The implant of claim 1, wherein the microscale roughened surface includes a grit blasted surface.

6. The implant of claim 5, wherein the microscale roughened surface includes peak-to-valley irregularity distances of about 10 microns to about 30 microns and peak-to-peak distances of less than about 3 microns.

7. The implant of claim 1, wherein the microscale roughened surface includes an acid etched surface.

8. The implant of claim 7, wherein the acid etched surface is a sulfuric acid and a hydrochloric acid-etched surface.

9. The implant of claim 1, wherein the nanopitting is formed by immersing the implant in a solution including hydrogen peroxide and a basic solution.

10. The implant of claim 9, wherein the basic solution includes sodium hydroxide.

11. The implant of claim 9, wherein the basic solution includes potassium hydroxide solution.

12. The implant of claim 1, wherein the nanopitting is in the range of about 1 nanometer to about 100 nanometers.

13. The implant of claim 1, further including discrete nanoparticles superimposed on the nanoscale roughened surface.

14. The implant of claim 13, further including a sodium lactate coating on the discrete nanoparticles.

15. An implant to be implanted into living bone, comprising:

a head portion having a non-rotational features;

a lowermost end opposing the head portion; and

a threaded bottom portion for engaging bone between the head portion and the lowermost end, wherein the threaded bottom portion includes a microscale roughened surface having peak-to-valley heights of about 10 microns to about 30 microns and a nanoscale roughened surface superimposed on the microscale roughened surface, the nanoscale roughened surface having peak-to-valley heights of less than about 10 microns superimposed on the microscale roughened surface, the nanoscale roughened surface includes nanopitting.

16. The implant of claim 15, wherein the nanoscale roughened surface has peak-to-valley heights of about 1 micron to about 3 microns.

17. The implant of claim 15, further including discrete nanoparticles on the nanoscale roughened surface.

18. The implant of claim 17, further including a sodium lactate coating on the discrete nanoparticles.

19. The implant of claim 15, wherein the implant is a dental implant.

20. The implant of claim 15, wherein the nanopitting is formed by immersing the implant in a solution including hydrogen peroxide and a basic solution, the basic solution is a potassium hydroxide solution having a concentration of about 3-5% w/w and the hydrogen peroxide has a concentration of about 13-22% w/w.