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Fine particles coated with lipid membrane

  • US 9,757,344 B2
  • Filed: 02/01/2010
  • Issued: 09/12/2017
  • Est. Priority Date: 10/04/2000
  • Status: Expired due to Fees
First Claim
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1. A coated fine particle comprising:

  • (i) a complex containing a drug, a cationic lipid, and a water-soluble polymer derivative,wherein the drug is a nucleic acid and the complex is obtained by mixing the drug ,the water-soluble polymer derivative, and the cationic lipid in water,wherein the complex has a diameter of 10 nm to 1,000 nm, andwherein the water-soluble polymer derivative is one or more member(s) selected from a copolymer of ethylene glycol with propylene glycol, and a glycerol ester, and(ii) a lipid membrane formed of lipid(s),wherein the lipid(s) is selected from phosphatidylserine, phosphatidylglycerol, lysophosphatidylcholine, polyethylene glycolated phospholipid, egg yolk lecithin, soybean lecithin and hydrogenated phospholipid, andwherein the complex is coated with the lipid membrane.

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