Remote control of power or polarity selection for a neural stimulator

• US 9,757,571 B2
• Filed: 10/31/2013
• Issued: 09/12/2017
• Est. Priority Date: 01/28/2011
• Status: Active Grant

• Current Assignee: Curonix Company Limited
• Original Assignee: Micron Devices LLC
• Inventors: Perryman, Laura Tyler, Larson, Patrick, Andresen, Chad
• Primary Examiner(s): Wehrheim, Lindsey G
• Application Number:
  US14/068,828
• Publication Number:
  US 20140058480A1
• Time in Patent Office: 1,412 Days
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/37223 Circuits for electromagnetic coupling
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: A61N 1/3727 characterised by the modulation technique

Abstract

A system, including: an implantable neural stimulator including electrodes, at least one antenna and an electrode interface; a radio-frequency (RF) pulse generator module comprising an antenna module configured to send an input signal to the antenna in the implantable neural stimulator through electrical radiative coupling, the input signal containing electrical energy and polarity assignment information that designates polarity assignments of the electrodes in the implantable neural stimulator; and wherein the implantable neural stimulator is configured to: control the electrode interface such that the electrodes have the polarity assignments designated by the polarity assignment information, create one or more electrical pulses suitable for modulation of neural tissue using the electrical energy contained in the input signal, and supply the electrical pulses to the electrodes through the electrode interface such that the electrodes apply the electrical pulses to the neural tissue with the polarity assignments designated by the polarity assignment information.

Claims

1. A system for modulating neural tissue in a patient comprising:

an implantable neural stimulator comprising one or more electrodes, at least one antenna and an electrode interface;

a radio-frequency (RF) pulse generator module comprising an antenna module configured to send an input signal to the at least one antenna in the implantable neural stimulator through electrical radiative coupling, the input signal containing electrical energy and polarity assignment information that designates polarity assignments of the one or more electrodes in the implantable neural stimulator, wherein the antenna module is further configured transmit to the implantable neural stimulator a first input signal containing the electrical energy and a second input signal containing the polarity assignment information, wherein the first input signal has a different carrier frequency than the second input signal; and

wherein the implantable neural stimulator is configured to;

control the electrode interface such that the one or more electrodes have the polarity assignments designated by the polarity assignment information,

create one or more electrical pulses suitable for modulation of neural tissue using the electrical energy contained in the input signal, and

supply the electrical pulses to the one or more electrodes through the electrode interface such that the one or more electrodes apply the electrical pulses to the neural tissue with the polarity assignments designated by the polarity assignment information.

2. The system of claim 1 wherein the implantable neural stimulator is configured to transmit a stimulus feedback signal indicating one or more parameters of the electrical pulses to the antenna module of the RF pulse generator module.

3. The system of claim 2 wherein the RF pulse generator module comprises one or more circuits coupled to the antenna module and configured to receive the stimulus feedback signal and adjust parameters of the input signal based on the stimulus feedback signal.

4. The system of claim 2 wherein:

the polarities designated by the polarity assignment information include a negative polarity, a positive polarity, or a neutral polarity;

the electrical pulses include a cathodic portion and an anodic portion; and

the electrode interface comprises a polarity routing switch network that includes a first input that receives the cathodic portion of the electrical pulses and a second input that receives the anodic portion of the electrical pulses, the polarity routing switch network configured to route the cathodic portion to the electrodes of the one or more electrodes designated with a negative polarity, route the anodic portion to the electrodes of the one or more electrodes designated with a positive polarity, and disconnect the electrodes of the one or more electrodes designated with a neutral polarity from the electrical pulses.

5. The system of claim 4 wherein the implantable neural stimulator comprises one or more circuits having a register with an output coupled to a selection input of the polarity routing switch network, wherein the register is configured to store the polarity assignment information and send the stored polarity assignment information from the register output to the selection input of the polarity routing switch network to control the polarity routing switch network to route the cathodic portion to the electrodes of the one or more electrodes with a designated negative polarity, route the anodic portion of the electrodes of the one or more electrodes designated with a positive polarity, and disconnect the electrodes of the one or more electrodes designated with a neutral polarity from the electrical pulses.

6. The system of claim 5 wherein the one or more circuits include a power-on reset circuit and a capacitor, wherein the capacitor stores a charge using a portion of the electrical energy contained in the input signal, and wherein the capacitor is configured to energize the power-on reset circuit to reset the stored polarity assignment information in the register when the implanted neural stimulator loses power.

7. The system of claim 6 wherein the one or more parameters include a current and a voltage of the electrical pulses, and the implantable neural stimulator comprises a current sensor configured to sense an amount of current in the electrical pulses and a voltage sensor configured to sense a voltage in the electrical pulses.

8. The system of claim 7 wherein the current sensor and the voltage sensor are coupled to a resistor placed in serial connection with the second input of the polarity routing switch network that receives the anodic portion of the electrical pulses.

9. The system of claim 8 wherein the current sensor and the voltage sensor are coupled to an analog controlled carrier modulator, the analog controlled carrier modulator being configured to communicate the sensed current and voltage to the antenna module.

10. The system of claim 1 wherein the antenna module comprises a first antenna configured to operate at a first frequency to transmit the first input signal and a second antenna configured to operate at a second frequency to receive the stimulus feedback signal from the at least one antenna of the implantable neural stimulator, wherein the second frequency of the second antenna is higher than a resonant frequency of the first antenna.

11. The system of claim 10 wherein the second frequency of the second antenna is a second harmonic of the resonant frequency of the first antenna.

12. The system of claim 10 wherein the second frequency and the resonant frequency are in a range from 300 MHz to 6 GHz.

13. The system of claim 1 wherein the at least one antenna of the implantable neural stimulator is between about 0.1 mm and 7 cm in length and between about 0.1 mm to 3 mm in width.

14. The system of claim 1 wherein the at least one antenna of the implantable neural stimulator is a dipole antenna.

15. The system of claim 1 wherein the implantable neural stimulator comprises a rectifying circuit coupled to an RC timer, wherein the rectifying circuit is configured to rectify the first input signal received by the at least one antenna to generate the electrical pulses and the RC timer is configured to shape the electrical pulses.

16. The system of claim 15 wherein the rectifying circuit comprises at least one full wave bridge rectifier, wherein the full wave bridge rectifier comprises a plurality of diodes, each diode being less than 100 micrometers in length.