Coagulation factor IX compositions and methods of making and using same
First Claim
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1. A polynucleotide encoding a factor IX fusion protein, which comprises a factor IX polypeptide and an extended recombinant polypeptide (XTEN), wherein the XTEN comprises an amino acid sequence having at least 90% sequence identity to a sequence selected from SEQ ID NOs:
- 35, 36, 37, 38, 43, 44, 45, and 46 and wherein the XTEN is capable of extending a half-life of the factor IX polypeptide.
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Abstract
The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
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Citations
23 Claims
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1. A polynucleotide encoding a factor IX fusion protein, which comprises a factor IX polypeptide and an extended recombinant polypeptide (XTEN), wherein the XTEN comprises an amino acid sequence having at least 90% sequence identity to a sequence selected from SEQ ID NOs:
- 35, 36, 37, 38, 43, 44, 45, and 46 and wherein the XTEN is capable of extending a half-life of the factor IX polypeptide.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
Specification