Compositions and methods for treating pancreatic cancer
First Claim
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1. A method for treating pancreatic cancer in a human subject in need thereof, comprising:
- sensitizing a pancreatic tumor in the subject to a chemotherapeutic agent, comprising sequentially administering to the subject an effective amount of Trabedersen for at least one cycle prior to administration of the chemotherapeutic agent; and
subsequently administering an effective amount of the chemotherapeutic agent to the subject,wherein the chemotherapeutic agent is Paclitaxel, Dacarbazine or a combination thereof, and wherein Trabedersen sensitizes the tumor to Paclitaxel, Dacarbazine or a combination thereof, so as to treat pancreatic cancer in the subject.
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Abstract
Provided herein are composition for sensitizing tumors to anti-tumor therapies. The compositions include antisense oligonucleotides against TGFβ2, wherein the compositions sensitize tumors to anti-tumor therapies. Also provided herein are method for treating cancer using the compositions described herein.
56 Citations
7 Claims
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1. A method for treating pancreatic cancer in a human subject in need thereof, comprising:
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sensitizing a pancreatic tumor in the subject to a chemotherapeutic agent, comprising sequentially administering to the subject an effective amount of Trabedersen for at least one cycle prior to administration of the chemotherapeutic agent; and subsequently administering an effective amount of the chemotherapeutic agent to the subject, wherein the chemotherapeutic agent is Paclitaxel, Dacarbazine or a combination thereof, and wherein Trabedersen sensitizes the tumor to Paclitaxel, Dacarbazine or a combination thereof, so as to treat pancreatic cancer in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification