System and method for continuously monitoring and presenting body substances
First Claim
1. A medical monitoring system for continuous monitoring of the glucose level and the lactate level of a critical care patient, wherein the monitoring system comprises:
- a display unit,a microdialysis or ultrafiltration catheter comprising an intracorporeal membrane,a first extracorporeal sensor in connection with the catheter, said sensor comprising at least one glucose electrode, at least one lactate electrode, and at least first and second blank electrodes, wherein in the direction of liquid flow past the sensor, the first blank electrode precedes the glucose electrode and the lactate electrode, and the second blank electrode follows the glucose electrode and the lactate electrode,a first unit, connected to the sensor and the display unit, adapted to;
receive a first glucose signal based on the level of glucose in an analyte from the patient measured by the sensor,transform the glucose signal into a graphically displayable glucose signal, andtransmit the graphically displayable glucose signal to the display unit of the monitoring system,a second unit, connected to the sensor and the display unit, adapted to;
receive a first lactate signal based on the level of lactate in an analyte from the patient measured by the sensor,transform the lactate signal into a graphically displayable lactate signal, andtransmit the graphically displayable lactate signal to the display unit of the monitoring system,an alarm system related to at least one of the glucose value and the lactate value, wherein the alarm system has a definable threshold value and is adapted to be triggered by a glucose or lactate value being above, on or below the threshold value, anda cross-talk alarm system related to cross-talk between the first blank electrode and the second blank electrode, wherein the cross-talk alarm system has a first predefined cross-talk threshold value and is adapted to be triggered by a difference between first and second values, based on signals from the first blank electrode and the second blank electrode, the difference being greater than the first predefined cross-talk threshold value.
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Abstract
A medical monitoring unit for continuously monitoring a glucose value and a lactate value is provided. The monitoring unit comprises: a display unit, a first unit adapted to: receive a glucose/lactate/pyruvate signal based on a measured glucose/lactate/pyruvate value, transform the glucose signal into a graphically displayable glucose/lactate/pyruvate signal, and transmit the graphically displayable glucose/lactate/pyruvate signal to the display unit of the monitoring unit, and a second unit adapted to: receive a glucose/lactate/pyruvate signal based on a measured glucose/lactate/pyruvate value, transform the glucose/lactate/pyruvate signal into a graphically displayable glucose/lactate/pyruvate signal, and transmit the graphically displayable glucose/lactate/pyruvate signal to the display unit of the monitoring unit. Furthermore, a system comprising the monitoring unit, and a sensor unit for sensing glucose and/or lactate and/or pyruvate values, is provided, as well as a method for performing the steps made possible through the provided unit and method.
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Citations
45 Claims
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1. A medical monitoring system for continuous monitoring of the glucose level and the lactate level of a critical care patient, wherein the monitoring system comprises:
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a display unit, a microdialysis or ultrafiltration catheter comprising an intracorporeal membrane, a first extracorporeal sensor in connection with the catheter, said sensor comprising at least one glucose electrode, at least one lactate electrode, and at least first and second blank electrodes, wherein in the direction of liquid flow past the sensor, the first blank electrode precedes the glucose electrode and the lactate electrode, and the second blank electrode follows the glucose electrode and the lactate electrode, a first unit, connected to the sensor and the display unit, adapted to; receive a first glucose signal based on the level of glucose in an analyte from the patient measured by the sensor, transform the glucose signal into a graphically displayable glucose signal, and transmit the graphically displayable glucose signal to the display unit of the monitoring system, a second unit, connected to the sensor and the display unit, adapted to; receive a first lactate signal based on the level of lactate in an analyte from the patient measured by the sensor, transform the lactate signal into a graphically displayable lactate signal, and transmit the graphically displayable lactate signal to the display unit of the monitoring system, an alarm system related to at least one of the glucose value and the lactate value, wherein the alarm system has a definable threshold value and is adapted to be triggered by a glucose or lactate value being above, on or below the threshold value, and a cross-talk alarm system related to cross-talk between the first blank electrode and the second blank electrode, wherein the cross-talk alarm system has a first predefined cross-talk threshold value and is adapted to be triggered by a difference between first and second values, based on signals from the first blank electrode and the second blank electrode, the difference being greater than the first predefined cross-talk threshold value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method of using a microdialysis or ultrafiltration catheter for continuously monitoring a glucose level and a lactate level of a critical care patient, wherein the method comprises the steps of:
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obtaining a liquid flow of analyte through an intracorporeal membrane into the catheter, transporting the liquid flow of analyte from the catheter to an extracorporeal sensor, wherein the extracorporeal sensor is capable of sensing glucose and lactate and comprises at least one glucose electrode, at least one lactate electrode, and at least first and second blank electrodes, wherein in the direction of liquid flow past the sensor, the first blank electrode precedes the glucose electrode and the lactate electrode, and the second blank electrode follows the glucose electrode and the lactate electrode, measuring the glucose level at the extracorporeal sensor, receiving, at a first unit, a first glucose signal based on the measured level of glucose, transforming the glucose signal to a graphically displayable glucose signal, and transmitting the graphically displayable glucose signal to a display unit, measuring the lactate level at the extracorporeal sensor, receiving, at a second unit, a first lactate signal based on the measured level of lactate, transforming the lactate signal into a graphically displayable lactate signal, and transmitting the graphically displayable lactate signal to the display unit, and receiving a first signal from the first blank electrode, receiving a second signal from the second blank electrode, converting the first signal and the second signal into a first value and a second value, comparing the first value and the second value, and detecting if the difference between the first value and second value is equal to or larger than a first predefined cross-talk threshold, and triggering a crosstalk signal when the difference is equal to or larger than the first predefined cross-talk threshold value. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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Specification