Skin collagen production-promoting agent

• US 9,763,868 B2
• Filed: 09/24/2015
• Issued: 09/19/2017
• Est. Priority Date: 02/09/2011
• Status: Active Grant

• Current Assignee: Megmilk Snow Brand Company Limited
• Original Assignee: Megmilk Snow Brand Company Limited
• Inventors: Ueno, Hiroshi, Morita, Yoshikazu, Ono, Aiko, Katoh, Ken, Ueda, Noriko
• Primary Examiner(s): ROMEO, DAVID S
• Application Number:
  US14/863,477
• Publication Number:
  US 20160015618A1
• Time in Patent Office: 726 Days
• Field of Search: None
• CPC Class Codes: A23L 2/02 containing fruit or vegetable juices
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A23L 2/66 Proteins
• CPC Class Codes: A23L 33/17 Amino acids, peptides or proteins
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/318 having an effect on skin health and hair or coat
• CPC Class Codes: A23V 2250/54 Proteins
• CPC Class Codes: A61K 2800/592 Mixtures of compounds complementing their respective functions
• CPC Class Codes: A61K 2800/74 Biological properties of particular ingredients
• CPC Class Codes: A61K 38/018 from milk
• CPC Class Codes: A61K 38/1841 Transforming growth factor [TGF]
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

A problem of the present invention is to provide a skin collagen production-promoting agent without safety problems. Another problem of the present invention is to provide a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product containing such a substance. TGF-β and/or a TGF-β degradation product, which is acquired by degrading TGF-β with a protease such as pepsin, pancreatin, etc., are used as a skin collagen production-promoting agent or the active ingredient of a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product. The aforementioned TGF-β and/or TGF-β degradation product have an effect of increasing the collagen content of the skin.

Claims

1. A method of increasing the collagen content in the skin of a subject comprising orally administering a TGF-β

degradation product to a subject in recognized need thereof in an amount effective to increase the collagen content in the skin of the subject,

wherein the TGF-β

degradation product is acquired by degrading TGF-β

with pancreatin, and

wherein the TGF-β

degradation product has an average molecular weight of 500 or more and 8,000 or less.

3. The method according to claim 1, which comprises orally administering said TGF-β

degradation product in combination with vitamin C.

5. The method according to claim 1, wherein the TGF-β

degradation product has an average molecular weight of 1500 or more and 6500 or less.

2. A method of increasing the collagen content in the skin of a subject comprising orally administering 10 μ

g per day or more of a TGF-β

degradation product to a subject in recognized need thereof to increase the collagen content in the skin of the subject,

wherein the TGF-β

degradation product is acquired by degrading TGF-β

with pancreatin, and

wherein the TGF-β

degradation product has an average molecular weight of 500 or more and 8,000 or less.

4. The method according to claim 2, which comprises orally administering said TGF-β

degradation product in combination with vitamin C.

6. The method according to claim 2, wherein the TGF-β

degradation product has an average molecular weight of 1500 or more and 6500 or less.