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Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use

  • US 9,764,039 B2
  • Filed: 07/10/2014
  • Issued: 09/19/2017
  • Est. Priority Date: 07/10/2013
  • Status: Active Grant
First Claim
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1. An antibody of the IgG class comprising six or fewer site-specific non-natural amino acid residues, wherein at least one of said site-specific non-natural amino acid residues comprises an azide moiety and at least one of said site-specific non-natural amino acid residues comprises a tetrazine moiety, wherein at least one of the said site-specific non-natural amino acid residues comprising the azide moiety or the tetrazine moiety is at heavy chain site 404 according to the EU index of Kabat.

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