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Immobilised biological entities

  • US 9,764,068 B2
  • Filed: 07/07/2016
  • Issued: 09/19/2017
  • Est. Priority Date: 03/11/2011
  • Status: Active Grant
First Claim
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1. A process for the manufacture of a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 10,000 to 300,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:

  • 1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto and (v) wherein the hyperbranched polymer is not a dendrimer, the process comprising, in any order;

    i. reacting a plurality of functional end groups of the hyperbranched polymer molecules with anti-coagulant entities such that each hyperbranched polymer molecule is covalently linked to a plurality of anti-coagulant entities; and

    ii. attaching the hyperbranched polymer molecules to the surface of a device.

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