Prediction, visualization, and control of drug delivery by infusion pumps
First Claim
1. A system for controlling a drug delivery profile, the system comprising:
- at least one drug pump that produces a drug flow, wherein the at least one drug pump dispenses at least a first drug;
at least one carrier fluid pump that produces a carrier fluid flow;
a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow delivered to a delivery point;
a fluid path for carrying the mixed flow between the flow junction structure and the delivery point, at least a portion of the fluid path being represented by a dead volume;
a first controllable valve disposed between the at least one drug pump and the flow junction structure;
a second controllable valve disposed between the at least one carrier fluid pump and the flow junction structure; and
a control module configured to control a drug delivery profile at the delivery point in accordance with a target drug delivery profile and a predictive model of the mixed flow,wherein the control module is configured to vary a drug flow rate by controlling the first controllable valve, and vary a carrier fluid flow rate by controlling the second controllable valve,wherein each of the drug flow rate and the carrier fluid flow rate is varied relative to corresponding target rates associated with the target drug delivery profile such that an initial drug flow rate and an initial carrier fluid flow rate are higher than the corresponding target rates while a ratio between the drug flow rate and the carrier fluid flow rate is substantially fixed in accordance with a target drug concentration in the mixed flow corresponding to the target drug delivery profile, andwherein the predictive model is usable for predicting variations in the drug concentration along the fluid path, the predictive model being based on a plurality of structural parameters related to propagation of the mixed flow through the fluid path, the structural parameters including the dead volume associated with the fluid path.
8 Assignments
0 Petitions
Accused Products
Abstract
Systems for predicting a drug delivery profile as described herein include at least one drug pump and/or a controllable valve that produce a drug flow and dispense at least a first drug. The system also includes at least one carrier fluid pump and/or another controllable valve that produces a carrier fluid flow, a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow, and a fluid path for carrying the mixed flow between the flow junction structure and a delivery point. The system further includes a processing device configured to predict the drug delivery profile at the delivery point based on determining a predicted time variation of drug concentration at the delivery point using at least a model of the mixed flow. The model includes a plurality of parameters related to propagation of the mixed flow through the fluid path.
53 Citations
13 Claims
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1. A system for controlling a drug delivery profile, the system comprising:
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at least one drug pump that produces a drug flow, wherein the at least one drug pump dispenses at least a first drug; at least one carrier fluid pump that produces a carrier fluid flow; a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow delivered to a delivery point; a fluid path for carrying the mixed flow between the flow junction structure and the delivery point, at least a portion of the fluid path being represented by a dead volume; a first controllable valve disposed between the at least one drug pump and the flow junction structure; a second controllable valve disposed between the at least one carrier fluid pump and the flow junction structure; and a control module configured to control a drug delivery profile at the delivery point in accordance with a target drug delivery profile and a predictive model of the mixed flow, wherein the control module is configured to vary a drug flow rate by controlling the first controllable valve, and vary a carrier fluid flow rate by controlling the second controllable valve, wherein each of the drug flow rate and the carrier fluid flow rate is varied relative to corresponding target rates associated with the target drug delivery profile such that an initial drug flow rate and an initial carrier fluid flow rate are higher than the corresponding target rates while a ratio between the drug flow rate and the carrier fluid flow rate is substantially fixed in accordance with a target drug concentration in the mixed flow corresponding to the target drug delivery profile, and wherein the predictive model is usable for predicting variations in the drug concentration along the fluid path, the predictive model being based on a plurality of structural parameters related to propagation of the mixed flow through the fluid path, the structural parameters including the dead volume associated with the fluid path. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for controlling a drug delivery profile, the system comprising:
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a first controllable valve that controls a drug flow; a second controllable valve that controls a carrier fluid flow; a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow delivered to a delivery point; a fluid path for carrying the mixed flow between the flow junction structure and the delivery point, at least a portion of the fluid path being represented by a dead volume; and a control module configured to control a drug delivery profile at the delivery point in accordance with a target drug delivery profile and with a predictive model of the mixed flow, wherein the control module is configured to vary a drug flow rate by controlling the first controllable valve, and vary a carrier fluid flow rate by controlling the second controllable valve, wherein each of the drug flow rate and the carrier flow rate is varied relative to corresponding target rates associated with the target drug delivery profile such that an initial drug flow rate and an initial carrier fluid flow rate are higher than the corresponding target rates while a ratio between the drug flow rate and the carrier fluid flow rate is substantially fixed in accordance with a target drug concentration in the mixed flow corresponding to the target drug delivery profile, and wherein the predictive model is usable for predicting variations in the drug concentration along the fluid path, the predictive model being based on a plurality of structural parameters related to propagation of the mixed flow through the fluid path, the structural parameters including the dead volume associated with the fluid path. - View Dependent Claims (12, 13)
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Specification