Drug delivery apparatus
First Claim
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1. A drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity over a period of time, the apparatus comprising:
- a cannula for facilitating fluid flow through a lumen thereof to and from the bodily cavity;
at least one hollow member defining a lumen in fluid communication with the cannula,a leaky check valve comprising a one-way check valve and a leak path, the leaky check valve disposed within at least one of the cannula or the at least one hollow member and configured to enable a fluid flow through the at least one hollow member and the cannula in a first direction at a first rate and in a second direction opposite to the first direction and at a second rate different than the first rate; and
an actuator for driving fluid through the at least one hollow member and the cannula, the actuator being adapted to operate non-continuously.
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Abstract
An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
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Citations
20 Claims
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1. A drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity over a period of time, the apparatus comprising:
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a cannula for facilitating fluid flow through a lumen thereof to and from the bodily cavity; at least one hollow member defining a lumen in fluid communication with the cannula, a leaky check valve comprising a one-way check valve and a leak path, the leaky check valve disposed within at least one of the cannula or the at least one hollow member and configured to enable a fluid flow through the at least one hollow member and the cannula in a first direction at a first rate and in a second direction opposite to the first direction and at a second rate different than the first rate; and an actuator for driving fluid through the at least one hollow member and the cannula, the actuator being adapted to operate non-continuously. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for delivering a drug into a bodily fluid in a bodily cavity over a period of time, the method comprising:
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providing a drug delivery apparatus comprising; a cannula in fluid communication with a bodily cavity; at least one hollow member coupled to the cannula; a leaky check valve comprising a one-way check valve and a leak path, the leaky check valve disposed within at least one of the cannula or the at least one hollow member and configured to enable a fluid flow through the at least one hollow member and the cannula in a first direction at a first rate and in a second direction at a second rate different than the first rate; and an actuator; activating the actuator to drive a carrier fluid in the first direction through the one-way check valve and the leak path and into the bodily cavity at the first rate; and withdrawing a second fluid in the second direction through the leak path of the leaky check valve at the second rate. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification