System and method for synchronizing energy delivery to the cardiac rhythm

• US 9,764,145 B2
• Filed: 10/31/2014
• Issued: 09/19/2017
• Est. Priority Date: 05/28/2009
• Status: Active Grant

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: AngioDynamics, Inc.
• Inventors: Callas, Peter, Lovewell, James, Stribling, Bradley C., Warden, Dave
• Primary Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US14/529,811
• Publication Number:
  US 20150088220A1
• Time in Patent Office: 1,054 Days
• Field of Search: 607 5, 607 9, 607509
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371

Abstract

A system for synchronizing application of treatment signals with a cardiac rhythm is provided. The system includes a memory that receives and stores a synchronization signal indicating that a predetermined phase such as R-wave of a cardiac rhythm of a patient has started. A synchronization module analyzes whether the stored synchronization signal is erroneous and if so, prevents a medical treatment device from applying a treatment energy signal such as an IRE pulse to a patient to take into account an irregular heart beat and noise in the synchronization signal in order to maximize safety of the patient.

Claims

1. A system for synchronizing application of treatment signals with a cardiac rhythm, comprising:

a cardiac device that receives a first synchronization signal indicating that a patient is in a predetermined phase of a cardiac rhythm; and

a synchronization module coupled to the cardiac device to receive the first synchronization signal, a blanking period beginning after receiving the first synchronization signal, the synchronization module operable to automatically extend the blanking period the moment a second synchronization signal is received during the blanking period, the synchronization module automatically extends the blanking period from the time the second synchronization signal is received without ever stopping the blanking period to prevent the treatment signal from being applied to the patient during the extended blanking period.

2. The system of claim 1, wherein the synchronization module is operable to dynamically extend the blanking period when a new synchronization signal is received before the blanking period expires.

3. The system of claim 1, wherein the synchronization module is operable to:

start a blanking period after receiving the synchronization signal;

control a medical treatment device to apply a first treatment signal; and

once the first treatment signal has been applied, prevent the medical treatment device from applying a subsequent treatment signal within the blanking period.

4. The system of claim 1, wherein the synchronization module is operable to start a new blanking period when a subsequent synchronization signal is received by the cardiac device after the blanking period.

5. The system of claim 1, wherein the synchronization module is operable to:

start a new blanking period when a subsequent synchronization signal is received after the blanking period;

control a medical treatment device to apply a first treatment signal; and

prevent the medical treatment device from applying a subsequent treatment signal within the new blanking period.

6. The system of claim 1, wherein the synchronization module, after receiving the synchronization signal, controls a medical treatment device to apply a first treatment signal after waiting a predetermined time period from the receipt of the synchronization signal.

7. The system of claim 6, wherein the synchronization module controls the medical treatment device to apply at least one IRE pulse as the first treatment signal.

8. The system of claim 1, wherein the synchronization module receives the synchronization signal for each occurrence of an R-wave from the cardiac device.

9. The system of claim 1, wherein the synchronization module is operable to:

start a blanking period after receiving the synchronization signal;

control a medical treatment device to apply a first treatment signal;

once the first treatment signal has been applied, prevent the medical treatment device from applying a subsequent treatment signal within the blanking period;

dynamically extend the blanking period when a new synchronization signal is received within the blanking period.

10. A system for synchronizing application of treatment signals with a cardiac rhythm, comprising:

a cardiac device that continuously generates a first synchronization signal indicating that a patient is in a predetermined phase of a cardiac rhythm; and

a synchronization module coupled to the cardiac device to receive the first synchronization signal, a blanking period beginning after receiving the first synchronization signal and operable to automatically extend the blanking period when a second synchronization signal is received during the blanking period to prevent the treatment signal from being applied to the patient during the blanking period, resulting in a continuous blanking period of between 560-800 milliseconds.

11. The system of claim 10, wherein:

the cardiac device receive the synchronization signal which indicates that a T-wave phase of a cardiac rhythm of a patient has started; and

the synchronization module prevents the medical treatment device from applying a treatment signal during the blanking period.

12. The system of claim 10, wherein, based on the received synchronization signal, the synchronization module dynamically adjusts the blanking period during which an application of the treatment signal to the patient by the medical treatment device is prevented.

13. The system of claim 10, wherein the synchronization module is operable to:

start the blanking period after receiving the synchronization signal;

control the medical treatment device to apply a first treatment signal after receiving the synchronization signal; and

once the first treatment signal has been applied, prevent the medical treatment device from applying a subsequent treatment signal within the blanking period.

14. The system of claim 10, wherein:

the synchronization module, after receiving the synchronization signal, controls the medical treatment device to apply at least one IRE pulse as the first treatment signal after waiting a predetermined time period from the receipt of the synchronization signal.

15. The system of claim 10, wherein the synchronization module is operable to:

start a blanking period after receiving the synchronization signal;

control the medical treatment device to apply a first treatment signal;

once the first treatment signal has been applied, prevent the medical treatment device from applying a subsequent treatment signal within the blanking period;

dynamically extend the blanking period when a new synchronization signal is received within the blanking period.

16. A system for synchronizing application of treatment signals with a cardiac rhythm, comprising:

a cardiac device that continuously generates a first synchronization signal indicating that a patient is in a predetermined phase of a cardiac rhythm; and

an energy delivery control device that continuously receives the first synchronization signal from the cardiac device, a blanking period beginning after receiving the first synchronization signal, the energy delivery control device operable to automatically extend the blanking period when a second synchronization signal is received during the blanking period before the blanking period ends to prevent the treatment signal from being applied to the patient during the blanking period, wherein both the cardiac device and the energy delivery control device are both external to the patient'"'"'s body.