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Oxidizable species as an internal reference in control solutions for biosensors

  • US 9,766,198 B2
  • Filed: 12/10/2015
  • Issued: 09/19/2017
  • Est. Priority Date: 04/08/2005
  • Status: Active Grant
First Claim
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1. A method of distinguishing a control solution from a sample during operation of an electrochemical sensor, the electrochemical sensor measuring the amount of an analyte, the method comprising the acts of:

  • providing an electrochemical sensor having a working electrode, a counter electrode, a reagent, and a control solution, the reagent having a mediator, the control solution having an internal reference compound, a buffer, and a predetermined amount of analyte, the internal reference compound having a higher redox potential than the mediator, the internal reference compound being different from the buffer;

    applying a first potential to the electrochemical sensor sufficient to oxidize the internal reference compound and the mediator, and measuring the resulting electrical current;

    applying a second, lower potential to the electrochemical sensor, the lower potential being sufficient to oxidize the mediator and insufficient to oxidize the internal reference compound, and measuring the resulting electrical current; and

    determining whether a control solution or a sample is present based on the measured electrical currents.

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