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Parsing events during MS3 experiments

  • US 9,768,002 B2
  • Filed: 04/13/2016
  • Issued: 09/19/2017
  • Est. Priority Date: 12/20/2012
  • Status: Active Grant
First Claim
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1. A system for segmenting a collision-induced dissociation (CID) event of a mass spectrometry/mass spectrometry/mass spectrometry (MS3) experiment, comprising:

  • a mass spectrometer that performs an MS3 experiment on a sample;

    a processor in communication with the mass spectrometer thatdivides a CID event of the MS3 experiment into two time periods,at the beginning of a first time period of the CID event, instructs the mass spectrometer to both open a pulse valve in order to pulse a collision gas and apply a first CID voltage, andat the beginning of a second time period of the CID event, instructs the mass spectrometer to both close the pulse valve and apply a second CID voltage, wherein the mass spectrometer is pumped down during the second time period allowing pump down and CID to overlap in timereceives a plurality of second generation fragmentation spectra from the MS3 experiment, andselects the most intense second generation fragment ions with the lowest noise from the plurality of second generation fragmentation spectra.

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