Sensing of components in liquids

• US 9,770,196 B2
• Filed: 11/27/2013
• Issued: 09/26/2017
• Est. Priority Date: 11/27/2013
• Status: Active Grant

• Current Assignee: IMEC International
• Original Assignee: IMEC International, Universiteit Gent Vzw
• Inventors: Baets, Roeland, Ryckeboer, Eva
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US14/091,645
• Publication Number:
  US 20150148627A1
• Time in Patent Office: 1,399 Days
• CPC Class Codes: A61B 2562/04 Arrangements of multiple sensors of the same type
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 21/03 Cuvette constructions
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 2201/0662 Comparing measurements on two or more paths in one sample

Abstract

A sensing system and method for sensing a component in a liquid is disclosed. The system comprises a microfluidic channel, the microfluidic channel comprising a first end and a second end, wherein the microfluidic channel is open at the first end and closed at the second end. The system also comprises at least one measurement sensor positioned adjacent the first end, the measurement sensor being arranged for detecting a measurement signal and a reference sensor positioned in the microfluidic channel adjacent the second end, the reference sensor being arranged for detecting a reference signal of the liquid. The system further is configured for combining the measurement signal and the reference signal so as to filter out background influences.

Claims

1. A sensing system for sensing a component in a liquid, the system comprising:

a microfluidic diffusion channel, the microfluidic diffusion channel comprising an open end and a closed end, the microfluidic channel providing a diffusion path for the component in the liquid to be sensed,

at least one measurement sensor positioned at the open end, the measurement sensor being arranged for detecting a measurement signal indicating a characteristic of a portion of the component at the open end of the diffusion channel,

at least one reference sensor positioned in the microfluidic diffusion channel adjacent the closed end, the reference sensor being arranged for detecting a reference signal of the liquid, the diffusion channel and reference sensor being arranged such that the reference signal indicates a characteristic of a portion of the component arriving at the reference sensor by diffusion through the diffusion channel,

the system being configured for combining the measurement signal and the reference signal so as to filter out background influences.

2. A sensing system according to claim 1, wherein the measurement sensor is positioned in the microfluidic diffusion channel adjacent the open end.

3. A sensing system according to claim 1, wherein the measurement sensor and the reference sensor are any of an absorption sensor, a chemical sensor, an electrical sensor or an optical sensor.

4. A sensing system according to claim 1, wherein the measurement sensor and the reference sensor are based on a transmitter/receiver architecture wherein the transmitter of the measurement sensor is shared with the transmitter of the reference sensor.

5. A sensing system according to claim 1, wherein the measurement sensor and the reference sensor are optical sensors using a common excitation source as transmitter.

6. A sensing system according to claim 1, wherein the measurement sensor and the reference sensor are part of a dual beam optical sensor system.

7. A sensing system according to claim 1, wherein the measurement sensor and the reference sensor are spectral optical sensors allowing spectral characterisation of the fluid.

8. A sensing system according to claim 1, wherein the measurement sensor and the reference sensor are optical sensors based on a resonator element.

9. A sensing system according to claim 8, wherein the resonator element is an optical resonator ring.

10. A sensing system according to claim 1 wherein the measurement sensor comprises a first optical ring and wherein the reference sensor comprises a second optical ring and wherein the first optical ring is in contact with the liquid at the open end and the second optical ring is in contact with the liquid at the closed end.

11. A sensing system according to claim 1, wherein the microfluidic diffusion channel comprises a diffusion barrier for a component to be detected.

12. A sensing system according to claim 1, wherein the microfluidic diffusion channel has a curved shape such that the open end of the diffusion channel is nearby the closed end of the diffusion channel.

13. A sensing system according to claim 1, wherein the measurement sensor and the reference sensor are configured for directly combining the signals for compensating the measured signal with the reference signal.

14. A sensing system according to claim 1, the sensing system comprising a processor wherein the processor is configured to receive the measurement signal of the measurement sensor and the reference signal, and the processor is further configured to combine the measurement signal and the reference signal.

15. A sensing system according to claim 1, the sensing system being an implantable sensor for implantation into a living creature.

16. A sensing system according to claim 1, wherein the characteristic of the portion of the component at the open end of the diffusion channel is a presence of the component, a concentration of the component, an amount of the component, or a specific property of the component at the open end of the diffusion channel.

17. A sensing system according to claim 1, wherein the characteristic of the portion of the component at the closed end of the diffusion channel is a presence of the component, a concentration of the component, an amount of the component, or a specific property of the component at the closed end of the diffusion channel.

18. A sensing system according to claim 1, wherein the open end of the diffusion channel is open contact with an outer environment or volume in which the liquid is present, thereby the characteristic of the portion of the component at the open end of the diffusion channel changes at a faster rate than a rate of change of the characteristic of the portion of the component at the closed end of the diffusion channel.

19. A sensing system according to claim 1, wherein the length of the diffusion channel is at least two times a diffusion speed over time for the component in the liquid.

20. A method for sensing a component in a liquid, the method comprising:

obtaining a measurement signal of a fluid to be characterized using a measurement sensor positioned at an open end of a microfluidic diffusion channel, the measurement signal indicating a characteristic of a portion of the component at the open end of the diffusion channel,

obtaining a reference signal for the fluid to be characterized using a reference sensor positioned adjacent a closed end of the microfluidic diffusion channel, the microfluidic diffusion channel providing a diffusion path for the component in the liquid to be sensed, the diffusion channel and reference sensor being arranged such that the reference signal indicates a characteristic of a portion of the component arriving at the closed end by diffusion through the diffusion channel, and

compensating the measurement signal with the reference signal so as to filter out background influences.