Implantable thermal treatment method and apparatus

• US 9,770,280 B2
• Filed: 03/04/2014
• Issued: 09/26/2017
• Est. Priority Date: 01/23/2002
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Diederich, Chris J., Lotz, Jeffrey C., Nau, Jr., William H., Bradford, David S.
• Primary Examiner(s): Cwern, Jonathan
• Application Number:
  US14/197,107
• Publication Number:
  US 20140288544A1
• Time in Patent Office: 1,302 Days
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 2017/00092 using thermocouples
• CPC Class Codes: A61B 2017/00101 using an array of thermosensors
• CPC Class Codes: A61B 2017/00261 Discectomy
• CPC Class Codes: A61B 2018/00339 Spine, e.g. intervertebral disc
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 8/56 Details of data transmission or power supply
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints.

Claims

1. A method for delivering ultrasonic energy within a vertebral body of a vertebra to treat skeletal joint pain of a subject, the vertebral body comprising a bony structure located above a lower vertebral endplate and below an upper vertebral endplate of the vertebra, the method comprising:

penetrating a vertebral body by inserting a distal end of a cannula through an outer wall of the vertebral body and within the bony structure of the vertebral body;

wherein the cannula comprises a sharp distal tip and a central bore;

inserting an ultrasound energy delivery device through the central bore of the cannula and into the vertebral body;

wherein the ultrasound energy delivery device comprises at least one ultrasound transducer; and

activating the ultrasound energy delivery device to deliver ultrasound energy to at least a portion of the vertebral body sufficient to denervate a target region of the vertebral body;

wherein the ultrasound energy delivery device is positioned within the vertebral body when the ultrasound device is activated.

2. The method of claim 1, wherein inserting the ultrasound energy delivery device through the central bore of the cannula and into the vertebral body comprises advancing the ultrasound energy delivery device out of the distal tip of the cannula.

3. The method of claim 2, wherein the ultrasound energy delivery device is configured to deliver ultrasound energy in a first direction, and wherein the ultrasound energy delivery device is configured not to deliver a substantial level of ultrasound energy in a second direction.

4. The method of claim 1, further comprising deflecting a deflectable portion of the ultrasound energy delivery device.

5. The method of claim 4, wherein the ultrasound energy is delivered from the deflectable portion of the ultrasound energy delivery device.

6. The method of claim 1, further comprising steering the ultrasound energy delivery device to the target region.

7. The method of claim 6, wherein the ultrasound energy delivery device is steered by manipulating a proximal end of the ultrasound device.

8. The method of claim 1, further comprising passing coolant through a portion of the ultrasound energy delivery device to cool at least one of the portion of the vertebral body and the at least one ultrasound transducer.

9. The method of claim 1, further comprising:

removing the ultrasound energy delivery device from the body of the subject; and

removing the cannula from the body of the subject.

10. The method of claim 1, wherein the ultrasound energy delivery device is delivered as a long-term implant.

11. The method of claim 10, wherein the long-term implant comprises a control unit, a receiver, and a transmitter configured to facilitate communication with an external source outside of the body of the subject.

12. The method of claim 1, wherein the ultrasound transducer delivers a converging field of ultrasound energy to the region of tissue.

13. The method of claim 1, wherein the ultrasound transducer delivers a diverging field of ultrasound energy to the region of tissue.

14. The method of claim 1, wherein the ultrasound transducer delivers a substantially collimated field of ultrasound energy to the region of tissue.

15. A method for delivering ultrasonic energy within a vertebral body of a vertebra to treat skeletal joint pain of a subject, the vertebral body comprising a bony structure located above a lower vertebral endplate and below an upper vertebral endplate of the vertebra, the method comprising:

inserting a distal end of a spinal needle through an outer wall of a vertebral body and within the bony structure of the vertebral body;

wherein the spinal needle comprises a sharp distal tip configured to penetrate the outer wall of the vertebral body and a needle bore;

inserting an ultrasound energy delivery device through the needle bore of the spinal needle and within the vertebral body;

wherein the ultrasound energy delivery device comprises at least one ultrasound transducer; and

causing the at least one ultrasound transducer to deliver acoustic energy to at least a portion of the vertebral body sufficient to denervate a target region of the vertebral body comprising a nociceptive nerve.

16. The method of claim 15, further comprising deflecting a deflectable portion of the ultrasound energy delivery device upon insertion.

17. The method of claim 16, wherein the ultrasound energy is delivered from the deflectable portion of the ultrasound energy delivery device.

18. The method of claim 15, further comprising passing coolant through a portion of the ultrasound energy delivery device to cool at least one of the portion of the vertebral body and the ultrasound transducer.

19. The method of claim 15, further comprising:

removing the ultrasound energy delivery device from the body of the subject; and

removing the spinal needle from the body of the subject.

20. The method of claim 15, wherein the ultrasound energy delivery device is delivered as a long-term implant.